Results 61 to 70 of about 4,899 (211)
TRPC5 regulates axonal outgrowth in developing retinal ganglion cells [PDF]
Laboratory Investigation, 2020 The TRPC5 ion channel is activated upon depletion of intracellular calcium stores, as well as by various stimuli such as nitric oxide (NO), membrane stretch, and cold temperatures. TRPC5 is abundantly expressed in the central nervous system where it has important neuronal functions.
Mai Oda +4 more
openaire +2 more sources
Balancing Calcium Signals through TRPC5 and TRPC6 in Podocytes [PDF]
Journal of the American Society of Nephrology, 2011 Calcium (Ca(2+)) ions are important mediators of cellular homeostasis owing to their ability to elicit a dynamic, transient, and tightly regulated range of biochemical responses. More than a decade ago, a nonselective, Ca(2+)-permeable, cationic conductance was identified in podocytes downstream of angiotensin II (Ang II) signaling, but its molecular ...
Anna, Greka, Peter, Mundel
openaire +2 more sources
Therapeutic opportunities for targeting cold pain pathways [PDF]
, 2015 Cold pain is a frequent symptom in neuropathic pain. Compared to other pain modalities, such as heat pain, the mechanisms behind physiological and pathological cold pain remain elusive.
Lewis, Richard J. +3 more
core +1 more source
Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy [PDF]
, 2009 Background Ca2+ is known to be involved in a number of metastatic processes including motility and proliferation which can result in store-depletion of Ca2+.
Christopher Palmer +3 more
core +2 more sources
Clock genes regulate Ca2+ signaling and mitochondrial bioenergetics to inhibit Sjogren's disease
Arthritis &Rheumatology, Accepted Article.Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjogren's disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA seq, and mitochondrial activity were used to investigate the effects of ...
Viktor R. Drel +12 more
wiley +1 more source
Receptor-operated cation channels formed by TRPC4 and TRPC5 [PDF]
Naunyn-Schmiedeberg's Archives of Pharmacology, 2005 TRPC4 and TRPC5 form cation channels that contribute to phospholipase C-dependent Ca(2+) entry following stimulation of G-protein-coupled receptors or receptor tyrosine kinases. Surprisingly, in different studies, TRPC4 and TRPC5 have been shown to form either store-operated channels with a relatively high Ca(2+) permeability, or nonselective cation ...
Tim D, Plant, Michael, Schaefer
openaire +2 more sources
TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway
Scientific Reports, 2017 Adriamycin is a first-line chemotherapy agent against cancer, but the development of resistance has become a major problem. Although autophagy is considered to be an adaptive survival response in response to chemotherapy and may be associated with ...
Peng Zhang +6 more
doaj +1 more source
Redox regulation of calcium ion channels: Chemical and physiological aspects [PDF]
, 2011 Reactive oxygen species (ROS) are increasingly recognized as second messengers in many cellular processes. While high concentrations of oxidants damage proteins, lipids and DNA, ultimately resulting in cell death, selective and reversible oxidation of ...
Bogeski, Ivan +5 more
core +1 more source
Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley +1 more source
BMC Cancer, 2018 Background Elevated intracellular Ca2+ ([Ca2+] i ) level could lead to [Ca2+] i overload and promote apoptosis via different pathways. In our previously study, up-regulated expression of transient receptor potential canonical channel (TRPC5) was proven ...
Teng Wang +5 more
doaj +1 more source