Results 41 to 50 of about 4,899 (211)

TRPC5 Channel Sensitivities to Antioxidants and Hydroxylated Stilbenes [PDF]

Journal of Biological Chemistry, 2011
Transient receptor potential canonical 5 (TRPC5) forms cationic channels that are polymodal sensors of factors including oxidized phospholipids, hydrogen peroxide, and reduced thioredoxin. The aim of this study was to expand knowledge of the chemical-sensing capabilities of TRPC5 by investigating dietary antioxidants.
Naylor, Jacqueline, AL-Shawaf, Eman, McKeown, Lynn, Manna, Paul T., Porter, Karen E., O'Regan, David, Muraki, Katsuhiko, Beech, David J.   +7 more
openaire   +2 more sources

Molecular Determinants of the Sensitivity to Gq/11-Phospholipase C-dependent Gating, Gd3+ Potentiation, and Ca2+ Permeability in the Transient Receptor Potential Canonical Type 5 (TRPC5) Channel [PDF]

, 2016
Transient receptor potential canonical type 5 (TRPC5) is a Ca2+-permeable cation channel that is highly expressed in the brain and is implicated in motor coordination, innate fear behavior, and seizure genesis.
Chakraborty, Saikat Chakrabort, Chen, Xingjuan, Li, Wennan, Obukhov, Alexander G., Riley, Ashley M., Soliman, Mario, Stamatkin, Christopher W.   +6 more
core   +1 more source

Na⁺ entry through heteromeric TRPC4/C1 channels mediates (-)Englerin A-induced cytotoxicity in synovial sarcoma cells [PDF]

, 2017
The sesquiterpene (-)Englerin A (EA) is an organic compound from the plant Phyllanthus engleri which acts via heteromeric TRPC4/C1 channels to cause cytotoxicity in some types of cancer cell but not normal cells. Here we identified selective cytotoxicity
A Batova, A Beck, A Greka, A Riccio, AL Jackson, BC Fuchs, C Carson, C Sourbier, C Sourbier, CE Herzog, EL Spurrell, FJ Sulzmaier, H Al-Hussaini, H Suzuki, HN Rubaiy, J Myeong, J Myeong, JE Camacho Londono, JM David, JM Richter, KN Westlund, M Miller, MJ Ludlow, N Utsunomiya-Tate, R Ratnayake, RT Williams, T Rodrigues, U Storch, V Caropreso, VV Tsvilovskyy, Y Akbulut, Y Itoh, Z Wu   +32 more
core   +3 more sources

TRPC5 and the path towards analgesic drug development

Trends in Neurosciences, 2021
A recent study by Sadler et al. highlights transient receptor potential canonical 5 (TRPC5) as a potential target for treating pain conditions. This article discusses their findings in the context of analgesic drug development, an urgent pursuit required to combat the opioid crisis and help millions of people with chronic pain.
openaire   +3 more sources

Transient receptor potential canonical 5 channels plays an essential role in hepatic dyslipidemia associated with cholestasis

Scientific Reports, 2017
Transient receptor potential canonical 5 (TRPC5), a calcium-permeable, non-selective cation channel is expressed in the periphery, but there is limited knowledge of its regulatory roles in vivo.
Khadija M. Alawi, David Tandio, Jin Xu, Pratish Thakore, Georgia Papacleovoulou, Elizabeth S. Fernandes, Cristina Legido-Quigley, Catherine Williamson, Susan D. Brain   +8 more
doaj   +1 more source

Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease [PDF]

, 2018
Proteins of the TRPC family can form many homo- and heterotetrameric cation channels permeable to Na+, K+ and Ca2+. In this review, we focus on channels formed by the isoforms TRPC1, TRPC4 and TRPC5.
Bauer, CC, Beech, DJ, Bon, RS, Minard, A, Muraki, K, Rubaiy, HN, Wright, DJ   +6 more
core   +2 more sources

Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle. [PDF]

, 2020
In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Albert, AP, Baudel, MASM-A, Large, WA, Shi, J   +3 more
core   +1 more source

Conserved Gating Elements in TRPC4 and TRPC5 Channels [PDF]

Journal of Biological Chemistry, 2013
TRPC4 and TRPC5 proteins share 65% amino acid sequence identity and form Ca(2+)-permeable nonselective cation channels. They are activated by stimulation of receptors coupled to the phosphoinositide signaling cascade. Replacing a conserved glycine residue within the cytosolic S4-S5 linker of both proteins by a serine residue forces the channels into an
Andreas, Beck, Tilman, Speicher, Christof, Stoerger, Thomas, Sell, Viviane, Dettmer, Siti A, Jusoh, Ammar, Abdulmughni, Adolfo, Cavalié, Stephan E, Philipp, Michael X, Zhu, Volkhard, Helms, Ulrich, Wissenbach, Veit, Flockerzi   +12 more
openaire   +2 more sources

Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice

Journal of Neuroinflammation, 2021
Background Members of the transient receptor potential canonical (TRPC) protein family are widely distributed in the hippocampus of mammals and exert respective and cooperative influences on the functions of neurons.
Shiji Huo, Jiling Ren, Yunqing Ma, Ahsawle Ozathaley, Wenjian Yuan, Hong Ni, Dong Li, Zhaowei Liu   +7 more
doaj   +1 more source

Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels [PDF]

, 2017
The concentration of free cytosolic Ca(2+) and the voltage across the plasma membrane are major determinants of cell function. Ca(2+)-permeable non-selective cationic channels are known to regulate these parameters but understanding of these channels ...
Appleby, HL, Bailey, MA, Beech, DJ, Blythe, NM, Bon, RS, Cheung, SY, Christmann, M, Foster, R, Gaunt, HJ, Hamzah, N, Henrot, M, Ludlow, MJ, McKeown, L, Miteva, K, Muraki, K, Musialowski, KE, Nussbaumer, P, Rubaiy, HN, Tanahashi, Y, Taylor, R, Waldmann, H   +20 more
core   +2 more sources