Results 31 to 40 of about 4,899 (211)

Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

eLife, 2021
TRPC5 channel is a nonselective cation channel that participates in diverse physiological processes. TRPC5 inhibitors show promise in the treatment of anxiety disorder, depression, and kidney disease.
Kangcheng Song, Miao Wei, Wenjun Guo, Li Quan, Yunlu Kang, Jing-Xiang Wu, Lei Chen   +6 more
doaj   +1 more source

Erythropoietin Increases Expression and Function of Transient Receptor Potential Canonical 5 Channels [PDF]

, 2011
Hypertension is a common complication in hemodialysis patients during erythropoietin (EPO) treatment. The underlying mechanisms of EPO-induced hypertension still remain to be determined. Increased transient receptor potential canonical (TRPC)
Friis, Ulla G, Jensen, Boye L, Liu, Ying, Scholze, Alexandra, Tepel, Martin, Thilo, Florian, Xu, Yunfei, Zheng, Junhua   +7 more
core   +1 more source

Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells [PDF]

Pflügers Archiv - European Journal of Physiology, 2010
TRPC5 is a member of the canonical transient receptor potential (TRPC) family of proteins that forms cationic channels either through homomultimeric assembly or heteromultimeric coordination with other TRPC proteins. It is expressed in a variety of cells including central neurones and endothelial cells and has susceptibility to stimulation by multiple ...
Wong, C-O, Sukumar, P, Beech, DJ, Yao, X
openaire   +3 more sources

Examining the role of transient receptor potential canonical 5 (TRPC5) in osteoarthritis

Osteoarthritis and Cartilage Open, 2020
Introduction: Osteo-arthritis (OA) involves joint degradation and usually pain; with mechanisms poorly understood and few treatment options. There is evidence that the transient receptor potential canonical 5 (TRPC5) mRNA expression is reduced in OA ...
João de Sousa Valente, Khadija M. Alawi, Patrik Keringer, Sabah Bharde, Faseeha Ayaz, Nurjahan Saleque, Xenia Kodji, Dibesh Thapa, Fulye Argunhan, Susan D. Brain   +9 more
doaj   +1 more source

Rat hypocretin/orexin neurons are maintained in a depolarized state by TRPC channels. [PDF]

PLoS ONE, 2010
In a previous study we proposed that the depolarized state of the wake-promoting hypocretin/orexin (hcrt/orx) neurons was independent of synaptic inputs as it persisted in tetrodotoxin and low calcium/high magnesium solutions.
Vesna Cvetkovic-Lopes, Emmanuel Eggermann, Aaron Uschakov, Jeremy Grivel, Laurence Bayer, Barbara E Jones, Mauro Serafin, Michel Mühlethaler   +7 more
doaj   +1 more source

Long-Term Treatment with Gadopentetic Acid or Gadodiamide Increases TRPC5 Expression and Decreases Adriamycin Nuclear Accumulation in Breast Cancer Cells

Cells, 2023
Gadopentetic acid and gadodiamide are paramagnetic gadolinium-based contrast agents (GBCAs) that are routinely used for dynamic contrast-enhanced magnetic resonance imaging (MRI) to monitor disease progression in cancer patients.
Weiheng Zhang, Mengyuan Wang, Weizhen Lv, Fletcher A. White, Xingjuan Chen, Alexander G. Obukhov   +5 more
doaj   +1 more source

Natural and synthetic flavonoid modulation of TRPC5 channels [PDF]

British Journal of Pharmacology, 2016
Background and PurposeThe TRPC5 proteins assemble to create calcium‐permeable, non‐selective, cationic channels. We sought novel modulators of these channels through studies of natural products.Experimental ApproachIntracellular calcium measurements and patch clamp recordings were made from cell lines.
Naylor, J, Minard, A, Gaunt, HJ, Amer, MS, Wilson, LA, Migliore, M, Cheung, SY, Rubaiy, H, Blythe, NM, Musialowski, KE, Ludlow, MJ, Evans, WD, Green, BL, Yang, H, You, Y, Li, J, Fishwick, CWG, Muraki, K, Beech, DJ, Bon, RS   +19 more
openaire   +3 more sources

Tonantzitlolone is a Nanomolar Potency Activator of TRPC1/4/5 Channels. [PDF]

, 2018
BACKGROUND AND PURPOSE The diterpene ester tonantzitlonone (TZL) is a natural product which displays cytotoxicity towards certain types of cancer cell such as renal cell carcinoma cells.
Abramowitz, Akbulut, Alexander, Alexander, Alexander, Beech, Busch, Busch, Camacho Londono, Caropreso, Carson, Curtis, Dietrich, Fan, Gaunt, Harding, Jasper, Just, Ludlow, Muraki, Naylor, Pfeffer, Ratnayake, Rubaiy, Rubaiy, Rubaiy, Rubaiy, Sourbier, Sourbier, Storch, Vinayagam, Westlund, Wu   +32 more
core   +1 more source

TRPC5 Does Not Cause or Aggravate Glomerular Disease [PDF]

Journal of the American Society of Nephrology, 2017
Transient receptor potential channel 5 (TRPC5) is highly expressed in brain and kidney and mediates calcium influx and promotes cell migration. In the kidney, loss of TRPC5 function has been reported to benefit kidney filter dynamics by balancing podocyte cytoskeletal remodeling. However, in vivo gain-in-function studies of TRPC5 with respect to kidney
Xuexiang, Wang, Ranadheer R, Dande, Hao, Yu, Beata, Samelko, Rachel E, Miller, Mehmet M, Altintas, Jochen, Reiser   +6 more
openaire   +2 more sources

Catechol estrogens stimulate insulin secretion in pancreatic β-cells via activation of the transient receptor potential A1 (TRPA1) channel [PDF]

, 2019
Estrogen hormones play an important role in controlling glucose homeostasis and pancreatic β-cell function. Despite the significance of estrogen hormones for regulation of glucose metabolism, little is known about the roles of endogenous estrogen ...
Cabrera, Over, Cerne, Rok, Chen, Xingjuan, Efanov, Alexander M., Ficorilli, James V., Ma, Wenzhen, Obukhov, Alexander G., Syed, Samreen K.   +7 more
core   +1 more source