TRPC5 in cardiovascular diseases [PDF]
Reviews in Cardiovascular Medicine, 2021 Cardiovascular diseases (CVD), especially acute myocardial infarction, are the leading cause of death, morbidity and disability across the world, affecting millions of people each year. Atherosclerosis (AS) is the major cause of CVD, and is a chronic
Sheng-Li Du +3 more
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TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia [PDF]
The EMBO JournalHypoglycemia triggers autonomic and endocrine counter-regulatory responses to restore glucose homeostasis, a response that is impaired in patients with diabetes and its long-term complication hypoglycemia-associated autonomic failure (HAAF). We show that
Jenny Bröker-Lai +39 more
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Plasma membrane mechanical stress activates TRPC5 channels. [PDF]
PLoS ONE, 2015 Mechanical forces exerted on cells impose stress on the plasma membrane. Cells sense this stress and elicit a mechanoelectric transduction cascade that initiates compensatory mechanisms.
Bing Shen +6 more
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Molecular architecture of the Gαi-bound TRPC5 ion channel
Nature Communications, 2023 G-protein coupled receptors (GPCRs) and ion channels serve as key molecular switches through which extracellular stimuli are transformed into intracellular effects, and it has long been postulated that ion channels are direct effector molecules of the ...
Jongdae Won +10 more
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N-palmitoyl glycine differentially modulates TRPM4 and TRPC5 and is causally linked to Brugada syndrome [PDF]
Communications BiologyBrugada syndrome (BrS) is an inherited cardiac arrhythmic disorder associated with an increased risk of malignant ventricular arrhythmia and sudden death.
Hongxuan Xu +5 more
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Structure-guided design of picomolar-level macrocyclic TRPC5 channel inhibitors with antidepressant activity [PDF]
Acta Pharmaceutica Sinica BRecent advances in ion channel structural biology have enhanced structure-based drug design, yet lipid-occupied binding pockets—often large and flat—remain a major hurdle for developing selective small molecules.
Tong Che +15 more
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TRPC5: a new entry to the chromaffin cell’s palette of ion channels that control adrenal response to hypoglycemia [PDF]
The EMBO JournalRegulation of glucose levels during insulin-evoked hypoglycemia is impaired in patients with diabetes and can lead to a condition called hypoglycemia-associated autonomic failure (HAAF). The underlying mechanism of the reduced sympathoadrenal response in
Emilio Carbone
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Adriamycin-induced podocyte injury via the Sema3A/TRPC5/Rac1 pathway [PDF]
Frontiers in MedicinePodocytopathies encompass kidney diseases where direct or indirect podocyte injury leads to proteinuria or nephrotic syndrome. Although Semaphorin3A (Sema3A) is expressed in podocytes and tubular cells in adult mammalian kidneys and has a common effect ...
Yan Liu +8 more
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BTDAzo - a photoswitchable TRPC5 channel activator [PDF]
Angewandte Chemie, 2022 Photoswitchable reagents to modulate protein activity are powerful tools for high-spatiotemporal-precision control over endogenous biological functions. TRPC5 is a Ca2+-permeable cation channel with distinct tissue-specific roles, ranging from synaptic function to hormone regulation.
Markus Müller +7 more
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TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy [PDF]
Frontiers in Pharmacology, 2018 Cardiac hypertrophy, induced by neurohumoral factors, including angiotensin II and endothelin-1, is a major predisposing factor for heart failure. These ligands can induce hypertrophic growth of neonatal rat cardiomyocytes (NRCMs) mainly through Ca2 ...
Caroline Sunggip +15 more
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