TrpC5 silencing reduces cell invasion and migration and enhances radiosensitivity in papillary thyroid carcinoma cells [PDF]
Frontiers in Cell and Developmental BiologyIntroductionCarcinoma (PTC) is the most common malignant tumor derived from thyroid follicular cells and represents the most common pathological type of thyroid malignancy.
Jing Yang +13 more
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Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice [PDF]
Advanced ScienceA major unresolved issue in managing severe pain is tolerance caused by repeated treatment of opioid analgesics. Here, it is demonstrated that tolerance‐inducing treatment with morphine results in the persistent downregulation of transient receptor ...
Li Wan +9 more
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A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models [PDF]
Science, 2017 Progressive kidney diseases are often associated with scarring of the kidney’s filtration unit, a condition called focal segmental glomerulosclerosis (FSGS).
Yiming Zhou +2 more
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Effects of TRPC1’s Lysines on Heteromeric TRPC5-TRPC1 Channel Function [PDF]
CellsBackground: TRPC5 proteins form plasma membrane cation channels and are expressed in the nervous and cardiovascular systems. TRPC5 activation leads to cell depolarization and increases neuronal excitability, whereas a homologous TRPC1 inhibits TRPC5 ...
Isaac S. Demaree +5 more
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pH-Sensitive TRPC5 Is Differentially Expressed in Various Common Skin Tumors [PDF]
BiologyTransient receptor potential classical or cation channels (TRPCs) are integral to tumor biology, particularly in maintaining Ca2+ homeostasis within cancer cells. TRPC5, a pH-sensitive member of this family, may act as a signaling molecule in the altered
Lara Hopmann +8 more
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TRPC5 channels participate in pressure-sensing in aortic baroreceptors [PDF]
Nature Communications, 2016 published_or_final_versio
Bing Shen, Ching-On Wong, Chun-Yin Lo
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Unique responses of the fixed stoichiometric TRPC1–TRPC5 concatemer to G proteins [PDF]
Frontiers in PhysiologyTransient receptor potential canonical (TRPC)5 channel is a non-selective cation channel that plays a significant role in membrane depolarization and calcium influx. TRPC5 not only forms homotetramers itself but also heterotetramers with TRPC1.
Hana Kang, Insuk So, Insuk So
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Molecular architecture of the human TRPC1/C5 heteromeric channel [PDF]
Nature CommunicationsTransient receptor potential (TRP) ion channels form heteromers through combinatorial associations of distinct subunits, contributing to the diversity of TRP channel functions.
Sun-Hong Kim +7 more
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TRPC5 Promotes Intermittent Hypoxia-Induced Cardiomyocyte Injury Through Oxidative Stress [PDF]
Nature and Science of SleepXuan Qiu,1,* Yanli Yao,1,* Yulan Chen,1 Yu Li,2 Xiaojing Sun,3 Xiaoli Zhu4 1Department of Hypertension, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, People’s Republic of China; 2Second Department of Comprehensive ...
Qiu X, Yao Y, Chen Y, Li Y, Sun X, Zhu X
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TRPV2 and TRPC5 are potential targets for astringent phytochemicals [PDF]
Current Research in Food ScienceAstringency is a multimodal sensory experience resulting from complex interactions between chemical compounds and the oral environment, involving tactile, chemosensory and thermosensory pathways.
Anna Kadkova +6 more
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