Results 21 to 30 of about 4,899 (211)
Sensing of Lysophospholipids by TRPC5 Calcium Channel [PDF]
Journal of Biological Chemistry, 2006 TRPC calcium channels are emerging as a ubiquitous feature of vertebrate cells, but understanding of them is hampered by limited knowledge of the mechanisms of activation and identity of endogenous regulators. We have revealed that one of the TRPC channels, TRPC5, is strongly activated by common endogenous lysophospholipids including ...
Philippa K, Flemming +9 more
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TRPC5 is essential in endothelium-dependent contraction of aorta from diet-induced obese mice
Fundamental Research, 2022 The role of the Ca2+-permeable ion channel TRPC5 in regulating vasocontraction in obesity is poorly understood. Here, we investigated whether TRPC5 contributes to vascular dysfunction in obesity by promoting endothelium-dependent contraction via ...
Yifei Zhu +7 more
doaj +1 more source
Potentiation of TRPC5 by Protons [PDF]
Journal of Biological Chemistry, 2007 Mammalian members of the classical transient receptor potential channel subfamily (TRPC) are Ca(2+)-permeable cation channels involved in receptor-mediated increases in intracellular Ca(2+). TRPC4 and TRPC5 form a group within the TRPC subfamily and are activated in a phospholipase C-dependent manner by an unidentified messenger. Unlike most other Ca(2+
Marcus, Semtner +3 more
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Odontoblast TRPC5 channels signal cold pain in teeth [PDF]
Science Advances, 2021 The odontoblast, with processes beyond the dentin-enamel boundary, is the initial site of TRPC5 cold transduction in teeth.
Laura Bernal +23 more
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TRPC5 Channel Inhibition Protects Podocytes in Puromycin-Aminonucleoside Induced Nephrosis Models
Frontiers in Medicine, 2021 Podocyte injury and the appearance of proteinuria are key features of several progressive kidney diseases. Genetic deletion or selective inhibition of TRPC5 channels with small-molecule inhibitors protects podocytes in rodent models of kidney disease ...
Yiming Zhou +14 more
doaj +1 more source
Intracellular calcium strongly potentiates agonist-activated TRPC5 channels [PDF]
Journal of General Physiology, 2009 TRPC5 is a calcium (Ca2+)-permeable nonselective cation channel expressed in several brain regions, including the hippocampus, cerebellum, and amygdala. Although TRPC5 is activated by receptors coupled to phospholipase C, the precise signaling pathway and modulatory signals remain poorly defined.
Blair, Nathaniel T. +2 more
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TRPC5 mediates TMZ resistance in TMZ-resistant glioblastoma cells via NFATc3-P-gp pathway
Translational Oncology, 2021 P-glycoprotein (P-gp) acts as a pump to transport cytotoxic drugs out of cells and is upregulated in cancer cells. Suppressing the expression of P-gp is an effective strategy to overcome multidrug resistance in cancer chemotherapy.
Yan Zou +6 more
doaj +1 more source
Isoliquiritigenin Inhibits Atherosclerosis by Blocking TRPC5 Channel Expression [PDF]
Cardiovascular Therapeutics, 2020 Isoliquiritigenin (ISL) is a flavonoid isolated mainly from the licorice plant, a traditional Chinese herb. ISL has shown anticancer, anti-inflammatory, antioxidant, and antidiabetic activities. However, the pharmaceutical effects of ISL on atherosclerosis are seldom explored.
Jie Qi +7 more
openaire +3 more sources
Cells, 2020 Phospholipid scramblase 1 (PLSCR1), a lipid-binding and Ca2+-sensitive protein located on plasma membranes, is critically involved in phosphatidylserine (PS) externalization, an important process in cell apoptosis.
Jizheng Guo +9 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 Recurrence is the main reason of treatment failure of redical resected colorectal cancer (CRC). Although some factors including staging and differentiation have been proven to useful for recurrence evaluation, prognosis of certain patients does not ...
Dongyan Cai +7 more
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