Results 121 to 130 of about 1,608 (146)

Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurons

, 2006
TRPM2, a member of the TRP ion channel family, is expressed both in the brain and immune cells of the monocyte lineage. Functionally, it is unique in its activation by intracellular ADP-ribose and both oxidative and nitrosative stress. To date studies of
Benham, C.D., Randall, A.D., McNulty, S., Schaefer, M., Tigue, N., Hill, K., Kelsell, R.E.   +6 more
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Lys1110 of TRPM2 is critical for channel activation

Biochemical Journal, 2013
TRPM2 (transient receptor potential melastatin 2) is a non-selective Ca2+-permeable cation channel activated by ADPR (adenosine diphosphoribose) and H2O2. It is widely expressed in mammalian cells and plays an important role in the regulation of various cell functions.
Taek-Keun, Kim, Joo Hyun, Nam, Won-Gyun, Ahn, Nam-Ho, Kim, Hwa-Yong, Ham, Chang-Won, Hong, Ju-Suk, Nam, Jongho, Lee, Sung-Oh, Huh, Insuk, So, Sung Joon, Kim, Dong-Keun, Song   +11 more
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Neutrophil Activation of Endothelial Cell-Expressed TRPM2 Mediates Transendothelial Neutrophil Migration and Vascular Injury

Circulation Research, 2017
Rationale: TRPM2 (transient receptor potential melastatin-2) expressed in endothelial cells (ECs) is a cation channel mediating Ca 2+ entry in response to ...
Chinnaswamy Tiruppathi, Jalees Rehman, Dheeraj Soni   +2 more
exaly   +2 more sources

TRPM2 activation: Paradigm shifted?

Cell Calcium, 2018
Transient receptor potential cation channel, subtype melastatin 2 (TRPM2), is important for several physiological functions, such as immune response or temperature regulation. Recently, the structure of full-length TRPM2 from zebrafish was published (Huang et al., 2018) proposing a new activation mechanism - is it really a paradigm shift or just ...
Ralf, Fliegert, Hans T, Hölzer, Andreas H, Guse   +2 more
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Pharmacology of JNJ-28583113: A novel TRPM2 antagonist

European Journal of Pharmacology, 2019
Transient receptor potential melastatin type 2 (TRPM2) is a cation channel activated by free intracellular ADP-ribose and reactive oxygen species. TRPM2 signaling has been linked to the pathophysiology of CNS disorders such as neuropathic pain, bipolar disorder and Alzheimer's disease.
Lawrence, Fourgeaud, Curt, Dvorak, Malika, Faouzi, John, Starkus, Sunil, Sahdeo, Qi, Wang, Brian, Lord, Heather, Coate, Natalie, Taylor, Yingbo, He, Ning, Qin, Alan, Wickenden, Nicholas, Carruthers, Timothy W, Lovenberg, Reinhold, Penner, Anindya, Bhattacharya   +15 more
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Architecture of the human TRPM2 channel

Science, 2018
Structural Biology Adenosine diphosphate–ribose (ADPR) mediates calcium (Ca2+) release by activating the transient receptor potential melastatin 2 (TRPM2) channel. Three structures now elucidate the conformational regulation mechanism of TRPM2 gating. Wang et al.
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TRPM2 Channel Regulates Endothelial Barrier Function

2009
Oxidative [Au1]stress, through the production of oxygen metabolites such as hydrogen peroxide[Au2] (H(2)O(2)), increases vascular endothelial permeability and plays a crucial role in several lung diseases. The transient receptor potential (melastatin) 2 (TRPM2) is an oxidant-sensitive, nonselective cation channel that is widely expressed in mammalian ...
Claudie M, Hecquet, Gias U, Ahmmed, Asrar B, Malik   +2 more
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Heat detection by the TRPM2 ion channel

Nature, 2020
Bruno Vilar, Chun-Hsiang Tan, Peter A. McNaughton   +2 more
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TRPM2-AS promotes cancer cell proliferation through control of TAF15

International Journal of Biochemistry and Cell Biology, 2020
Li Jin
exaly  

Bilirubin gates the TRPM2 channel as a direct agonist to exacerbate ischemic brain damage

Neuron, 2023
Lu-Yang Wang
exaly