Results 131 to 140 of about 2,388 (162)

Turning On TRPM3

Science Signaling, 2008
Pregnenolone sulphate, an endogenous steroid, directly activates the TRPM3 cation channel.
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TRPM3, a biophysical enigma?

Biochemical Society Transactions, 2007
TRPM3 [TRP (transient receptor potential) melastatin 3] is one of the least investigated proteins of the TRP family of ion channels. Heterologously expressed TRPM3 channels are constitutively active, have an outwardly rectifying current–voltage relationship and are inhibited by intracellular Mg2+ ions.
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Molecular basis of neurosteroid and anticonvulsant regulation of TRPM3

Nature Structural & Molecular Biology
Transient receptor potential channel subfamily M member 3 (TRPM3) is a Ca2+-permeable cation channel activated by the neurosteroid pregnenolone sulfate (PregS) or heat, serving as a nociceptor in the peripheral sensory system. Recent discoveries of autosomal dominant neurodevelopmental disorders caused by gain-of-function mutations in TRPM3 highlight ...
Ying Yin, Cheon-Gyu Park, Shasha Feng, Ziqiang Guan, Hyuk-Joon Lee, Feng Zhang, Kedar Sharma, Mario J. Borgnia, Wonpil Im, Seok-Yong Lee   +9 more
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Implications of TRPM3 and TRPM8 for sensory neuron sensitisation

Biological Chemistry
Abstract Sensory neurons serve to receive and transmit a wide range of information about the conditions of the world around us as well as the external and internal state of our body. Sensitisation of these nerve cells, i.e. becoming more sensitive to stimuli or the emergence or intensification of spontaneous activity, for example in the ...
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Phosphoinositide regulation of TRPM3 channels

Biophysical Journal, 2022
Siyuan Zhao, Vincenzo Carnevale, Tibor Rohacs   +2 more
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Exploring the gating mechanisms of the TRPM3 channel

Biophysical Journal, 2023
Charlotte H. Godfrey, Katherine Huffer, Kenton Swartz   +2 more
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Structural and functional analyses of a GPCR-inhibited ion channel TRPM3

Neuron, 2023
Roderick MacKinnon
exaly  

TRPM3 Is Expressed in Afferent Bladder Neurons and Is Upregulated during Bladder Inflammation

International Journal of Molecular Sciences, 2022
Thomas Voets, Marie Mulier, Wouter Everaerts   +2 more
exaly  

Pharmacological properties of TRPM3 isoforms are determined by the length of the pore loop

British Journal of Pharmacology, 2022
Thomas Voets, Yu Tian Wang, Vincenzo Davide Aloi   +2 more
exaly  

Partial Agonistic Actions of Sex Hormone Steroids on TRPM3 Function

International Journal of Molecular Sciences, 2021
Thomas Voets, Katharina Held, Joris Vriens   +2 more
exaly