Results 161 to 170 of about 10,867 (203)
TRPC and TRPV Channels’ Role in Vascular Remodeling and Disease [PDF]
International Journal of Molecular Sciences, 2020 Transient receptor potentials (TRPs) are non-selective cation channels that are widely expressed in vascular beds. They contribute to the Ca2+ influx evoked by a wide spectrum of chemical and physical stimuli, both in endothelial and vascular smooth ...
Raquel del Toro Estevez +2 more
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Blockade of TRPV channels by intracellular spermine
Journal of General Physiology, 2023 The Vanilloid thermoTRP (TRPV1–4) subfamily of TRP channels are involved in thermoregulation, osmoregulation, itch and pain perception, (neuro)inflammation and immune response, and tight control of channel activity is required for perception of noxious stimuli and pain. Here we report voltage-dependent modulation of each of human TRPV1, 3, and 4 by the
Grigory Maksaev, Colin Nichols
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TRPV Protein Family—From Mechanosensing to Cancer Invasion [PDF]
Biomolecules, 2021 Biophysical cues from the cellular microenvironment are detected by mechanosensitive machineries that translate physical signals into biochemical signaling cascades. At the crossroads of extracellular space and cell interior are located several ion channel families, including TRP family proteins, that are triggered by mechanical stimuli and drive ...
Tytti Karki, Sári Tojkander
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Structural insights into the gating mechanisms of TRPV channels
Cell Calcium, 2020 Transient Receptor Potential channels from the vanilloid subfamily (TRPV) are a group of cation channels modulated by a variety of endogenous stimuli as well as a range of natural and synthetic compounds. Their roles in human health make them of keen interest, particularly from a pharmacological perspective.
Vera Moiseenkova-Bell +2 more
exaly +4 more sources
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The role of TRPV channels in osteoporosis
Molecular Biology Reports, 2021As the world's population ages, the treatment of osteoporosis is a major problem to be addressed. The cause of osteoporosis remains unclear. Ca2+ is not only an important component of bones but also plays a key role in osteoporosis treatment. Transient receptor potential vanilloid (TRPV) channels are one of the TRP channel families that is widely ...
Na, Liu +4 more
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The mechanosensitive nature of TRPV channels
Pflugers Archiv European Journal of Physiology, 2005Transient receptor potential vanilloid (TRPV) channels are widely expressed in both sensory and nonsensory cells. Whereas the channels display a broad diversity to activation by chemical and physical stimuli, activation by mechanical stimuli is common to many members of this group in both lower and higher organisms.
Stefan Heller, Roger G O'Neil
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Expression of transient receptor potential vanilloid (TRPV) 1, 2, 3, and 4 in mouse inner ear
Acta Oto-Laryngologica, 2008 CONCLUSION: It is suggested that transient receptor potential vanilloids (TRPVs) may play a functional role in cell physiology and TRPV-4 and -2 may play an important part in fluid homeostasis in the inner ear.
Katsuhiro Hirakawa +2 more
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Expressions of TRPVs in the cholesteatoma epithelium
Acta Oto-Laryngologica, 2017We have recently proposed a hypothesis that acid leakage through the cholesteatoma epithelium mediates bone resorption in middle ear cholesteatoma. In the present study, we investigated the expressions of transient receptor potential vanilloid (TRPV) channels, which have been shown to play roles in the regulation of epidermal barrier function, in the ...
Ba Hung, Do +4 more
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Hot flash: TRPV channels in the brain
Trends in Neurosciences, 2009TRPV1 (transient receptor potential, vanilloid) channels belong to a family of ligand-gated ion channels gated not only by the binding of certain lipophilic molecules but also by extracellular protons and physical stimuli such as heat or osmotic pressure changes. These nonselective cation channels are permeable to Na(+) and K(+) and are also very Ca(2+)
Julie A, Kauer, Helen E, Gibson
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