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Structural insights into the gating mechanisms of TRPV channels
Cell Calcium, 2020 Transient Receptor Potential channels from the vanilloid subfamily (TRPV) are a group of cation channels modulated by a variety of endogenous stimuli as well as a range of natural and synthetic compounds. Their roles in human health make them of keen interest, particularly from a pharmacological perspective.
Ruth A Pumroy +2 more
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The role of TRPV channels in osteoporosis
Molecular Biology Reports, 2021As the world's population ages, the treatment of osteoporosis is a major problem to be addressed. The cause of osteoporosis remains unclear. Ca2+ is not only an important component of bones but also plays a key role in osteoporosis treatment. Transient receptor potential vanilloid (TRPV) channels are one of the TRP channel families that is widely ...
Na, Liu +4 more
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Vertebrate and invertebrate TRPV-like mechanoreceptors
Cell Calcium, 2003Our senses of touch, hearing, and balance are mediated by mechanosensitive ion channels. In vertebrates, little is known about the molecular composition of these mechanoreceptors, an example of which is the transduction channel of the inner ear's receptor cells, hair cells.
Hideki, Mutai, Stefan, Heller
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Hot flash: TRPV channels in the brain
Trends in Neurosciences, 2009TRPV1 (transient receptor potential, vanilloid) channels belong to a family of ligand-gated ion channels gated not only by the binding of certain lipophilic molecules but also by extracellular protons and physical stimuli such as heat or osmotic pressure changes. These nonselective cation channels are permeable to Na(+) and K(+) and are also very Ca(2+)
Julie A, Kauer, Helen E, Gibson
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TRPV Channels in Tumor Growth and Progression
2010Transient receptor potential (TRP) channels affect several physiological and pathological processes. In particular, TRP channels have been recently involved in the triggering of enhanced proliferation, aberrant differentiation, and resistance to apoptotic cell death leading to the uncontrolled tumor invasion.
SANTONI, Giorgio +2 more
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Expressions of TRPVs in the cholesteatoma epithelium
Acta Oto-Laryngologica, 2017We have recently proposed a hypothesis that acid leakage through the cholesteatoma epithelium mediates bone resorption in middle ear cholesteatoma. In the present study, we investigated the expressions of transient receptor potential vanilloid (TRPV) channels, which have been shown to play roles in the regulation of epidermal barrier function, in the ...
Ba Hung, Do +4 more
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TRPV channels and vascular function
Acta Physiologica, 2011Transient receptor potential channels, of the vanilloid subtype (TRPV), act as sensory mediators, being activated by endogenous ligands, heat, mechanical and osmotic stress. Within the vasculature, TRPV channels are expressed in smooth muscle cells, endothelial cells, as well as in peri-vascular nerves.
R L, Baylie, J E, Brayden
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2013
From a pharmacological point of view, the transient receptor potential (TRPV) family of ion channels are interesting drug targets. After the identification of the TRPV1 channel, an attractive candidate for analgesic intervention, many agonists and antagonists were generated.
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From a pharmacological point of view, the transient receptor potential (TRPV) family of ion channels are interesting drug targets. After the identification of the TRPV1 channel, an attractive candidate for analgesic intervention, many agonists and antagonists were generated.
openaire +1 more source
TRPV channels as thermosensory receptors in epithelial cells
Pflügers Archiv - European Journal of Physiology, 2005Temperature-sensitive transient receptor potential vanilloid (TRPV) ion channels are critical contributors to normal pain and temperature sensation and therefore represent attractive targets for pain therapy. When these channels were first discovered, most attention was focused on their potential contributions to direct thermal activation of peripheral
Hyosang, Lee, Michael J, Caterina
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Functional TRPV and TRPM channels in human preadipocytes
Pflügers Archiv - European Journal of Physiology, 2013Preadipocytes are widely used as an in vitro model to investigate proliferation, adipogenic differentiation, and lipodystrophy; however, cellular physiology and biology are not fully understood in human preadipocytes. The present study was to investigate the expression of transient receptor potential (TRP) channels in human preadipocytes and their ...
Tse, HF, CHE, H, Yue, J, Li, GR
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