Results 171 to 180 of about 10,867 (203)

Vertebrate and invertebrate TRPV-like mechanoreceptors

Cell Calcium, 2003
Our senses of touch, hearing, and balance are mediated by mechanosensitive ion channels. In vertebrates, little is known about the molecular composition of these mechanoreceptors, an example of which is the transduction channel of the inner ear's receptor cells, hair cells.
Hideki, Mutai, Stefan, Heller
openaire   +2 more sources

TRPV Channels in Tumor Growth and Progression

2010
Transient receptor potential (TRP) channels affect several physiological and pathological processes. In particular, TRP channels have been recently involved in the triggering of enhanced proliferation, aberrant differentiation, and resistance to apoptotic cell death leading to the uncontrolled tumor invasion.
SANTONI, Giorgio, FARFARIELLO, Valerio, AMANTINI, Consuelo   +2 more
openaire   +3 more sources

TRPV currents and their role in the nociception and neuroplasticity

Neuropeptides, 2016
Transient receptor potential channels sensitive to vanilloids (TRPVs) are group of ion channels which are sensitive to various tissue damaging signals and their activation is generally perceived as pain. Therefore, they are generally named as nociceptors.
Noothan Jyothi, Satheesh, Yoshio, Uehara, Julia, Fedotova, Miroslav, Pohanka, Dietrich, Büsselberg, Peter, Kruzliak   +5 more
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TRPV channels as thermosensory receptors in epithelial cells

Pflügers Archiv - European Journal of Physiology, 2005
Temperature-sensitive transient receptor potential vanilloid (TRPV) ion channels are critical contributors to normal pain and temperature sensation and therefore represent attractive targets for pain therapy. When these channels were first discovered, most attention was focused on their potential contributions to direct thermal activation of peripheral
Hyosang, Lee, Michael J, Caterina
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Pharmacology of TRPV Channels

2013
From a pharmacological point of view, the transient receptor potential (TRPV) family of ion channels are interesting drug targets. After the identification of the TRPV1 channel, an attractive candidate for analgesic intervention, many agonists and antagonists were generated.
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Functional TRPV and TRPM channels in human preadipocytes

Pflügers Archiv - European Journal of Physiology, 2013
Preadipocytes are widely used as an in vitro model to investigate proliferation, adipogenic differentiation, and lipodystrophy; however, cellular physiology and biology are not fully understood in human preadipocytes. The present study was to investigate the expression of transient receptor potential (TRP) channels in human preadipocytes and their ...
Tse, HF, CHE, H, Yue, J, Li, GR
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TRPV Channels’ Role in Osmotransduction and Mechanotransduction

2007
In signal transduction of metazoan cells, transient receptor potential (TRP) ion channels have been identified that respond to diverse external and internal stimuli, among them osmotic and mechanical stimuli. This chapter will summarize findings on the TRPV subfamily, both its vertebrate and invertebrate members.
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A TRPV family ion channel required for hearing in Drosophila

Nature, 2003
The many types of insect ear share a common sensory element, the chordotonal organ, in which sound-induced antennal or tympanal vibrations are transmitted to ciliated sensory neurons and transduced to receptor potentials. However, the molecular identity of the transducing ion channels in chordotonal neurons, or in any auditory system, is still unknown.
Janghwan, Kim, Yun Doo, Chung, Dae-Young, Park, SooKyung, Choi, Dong Wook, Shin, Heun, Soh, Hye Won, Lee, Wonseok, Son, Jeongbin, Yim, Chul-Seung, Park, Maurice J, Kernan, Changsoo, Kim   +11 more
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Fevers, TRPV channels, and birth defects

Science, 2017
Reproductive Biology Cardiac and craniofacial birth defects are common, but many cannot be attributed to specific mutations. An environmental trigger associated with these birth defects is maternal fever during the first trimester. Using chick and zebrafish embryos, Hutson et al.
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Link Between TRPV Channels and Mast Cell Function

2007
Mast cells are tissue-resident immune effector cells. They respond to diverse stimuli by releasing potent biological mediators into the surrounding tissue, and initiating inflammatory responses that promote wound healing and infection clearance. In addition to stimulation via immunological routes, mast cells also respond to polybasic secretagogues and ...
H, Turner, K A, del Carmen, A, Stokes
openaire   +2 more sources