TRPV Channels in Osteoarthritis: A Comprehensive Review [PDF]
BiomoleculesOsteoarthritis (OA) is a debilitating joint disorder that affects millions of people worldwide. Despite its prevalence, our understanding of the underlying mechanisms remains incomplete.
Changshun Chen +6 more
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Molecular details of ruthenium red pore block in TRPV channels [PDF]
EMBO ReportsTransient receptor potential vanilloid (TRPV) channels play a critical role in calcium homeostasis, pain sensation, immunological response, and cancer progression. TRPV channels are blocked by ruthenium red (RR), a universal pore blocker for a wide array
Ruth A Pumroy +9 more
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Blockade of TRPV channels by intracellular spermine. [PDF]
J Gen Physiol, 2023 This manuscript reports discovery of voltage-dependent inhibition of TRPV channels by intracellular polyamines and develops a kinetic model of this process. Polyamines are inhibitors of each TRPV sub-type.
Maksaev G, Yuan P, Nichols CG.
europepmc +7 more sources
Role of the TRPV Channels in the Endoplasmic Reticulum Calcium Homeostasis [PDF]
Cells, 2020 It has been widely established that transient receptor potential vanilloid (TRPV) channels play a crucial role in calcium homeostasis in mammalian cells.
Aurélien Haustrate +2 more
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Structural insights into the gating mechanisms of TRPV channels. [PDF]
Cell Calcium, 2020 Transient Receptor Potential channels from the vanilloid subfamily (TRPV) are a group of cation channels modulated by a variety of endogenous stimuli as well as a range of natural and synthetic compounds.
Pumroy RA +3 more
europepmc +7 more sources
Pathway-dependent cold activation of heat-responsive TRPV channels [PDF]
Scientific ReportsThe homotetrameric thermosensitive transient receptor potential vanilloid 1–4 (TRPV1-4) channels in sensory neurons are highly responsive to environmental heat stimuli.
Guangyu Wang
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TRPC and TRPV Channels' Role in Vascular Remodeling and Disease. [PDF]
Int J Mol Sci, 2020 Transient receptor potentials (TRPs) are non-selective cation channels that are widely expressed in vascular beds. They contribute to the Ca2+ influx evoked by a wide spectrum of chemical and physical stimuli, both in endothelial and vascular smooth ...
Martín-Bórnez M +3 more
europepmc +10 more sources
Human podocytes express functional thermosensitive TRPV channels. [PDF]
Br J Pharmacol, 2017 Background and PurposeHeat‐sensitive transient receptor potential vanilloid (TRPV) channels are expressed in various epithelial tissues regulating, among else, barrier functions. Their expression is well established in the distal nephron; however, we have no data about their presence in podocytes.
Ambrus L +4 more
europepmc +5 more sources
Expression Profiling of the Transient Receptor Potential Vanilloid (TRPV) Channels 1, 2, 3 and 4 in Mucosal Epithelium of Human Ulcerative Colitis [PDF]
Cells, 2018 The Transient Receptor Potential (TRP) family of selective and non-selective ion channels is well represented throughout the mammalian gastrointestinal track.
Theodoros Rizopoulos +2 more
doaj +3 more sources
Dynamic molecular portraits of ion-conducting pores characterize functional states of TRPV channels [PDF]
Communications ChemistryStructural biology is solving an ever-increasing number of snapshots of ion channel conformational ensembles. Deciphering ion channel mechanisms, however, requires understanding the ensemble dynamics beyond the static structures.
Yury A. Trofimov +6 more
doaj +3 more sources