Results 11 to 20 of about 2,492,447 (209)
Calcium binding and permeation in TRPV channels: Insights from molecular dynamics simulations. [PDF]
J Gen Physiol, 2023 Some calcium channels selectively permeate Ca2+, despite the high concentration of monovalent ions in the surrounding environment, which is essential for many physiological processes. Without atomistic and dynamical ion permeation details, the underlying
Liu C, Xue L, Song C.
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Molecular Physiology of TRPV Channels: Controversies and Future Challenges.
Annual Review of Physiology, 2023 The ability to detect stimuli from the environment plays a pivotal role in our survival. The molecules that allow the detection of such signals include ion channels, which are proteins expressed in different cells and organs.
T. Rosenbaum, L. Islas
semanticscholar +5 more sources
TRPV channels and vascular function. [PDF]
Acta Physiol (Oxf), 2011 Transient receptor potential channels, of the vanilloid subtype (TRPV), act as sensory mediators, being activated by endogenous ligands, heat, mechanical and osmotic stress. Within the vasculature, TRPV channels are expressed in smooth muscle cells, endothelial cells, as well as in peri-vascular nerves.
Baylie RL, Brayden JE.
europepmc +7 more sources
Expression of trpv channels during Xenopus laevis embryogenesis. [PDF]
Gene Expr Patterns, 2018 Transient receptor potential (TRP) cation channel genes code for an extensive family of conserved proteins responsible for a variety of physiological processes, including sensory perception, ion homeostasis, and chemical signal transduction.
Dong C, Paudel S, Amoh NY, Saha MS.
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Structural insight into the assembly of TRPV channels. [PDF]
Structure, 2014 Transient receptor potential (TRP) proteins are a large family of polymodal nonselective cation channels. The TRP vanilloid (TRPV) subfamily consists of six homologous members with diverse functions. TRPV1-TRPV4 are nonselective cation channels proposed to play a role in nociception, while TRPV5 and TRPV6 are involved in epithelial Ca²⁺ homeostasis ...
Huynh KW +5 more
europepmc +6 more sources
A molecular determinant of phosphoinositide affinity in mammalian TRPV channels. [PDF]
Sci Rep, 2016 Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is an important cofactor for ion channels. Affinity for this lipid is a major determinant of channel inhibition by depletion of PI(4,5)P2 upon phospholipase C (PLC) activation.
Velisetty P +6 more
europepmc +5 more sources
TRPV Channels in Mast Cells as a Target for Low-Level-Laser Therapy [PDF]
Cells, 2014 Low-level laser irradiation in the visible as well as infrared range is applied to skin for treatment of various diseases. Here we summarize and discuss effects of laser irradiation on mast cells that leads to degranulation of the cells. This process may
Lina Wang, Di Zhang, Wolfgang Schwarz
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A cooperative knock-on mechanism underpins Ca2+-selective cation permeation in TRPV channels. [PDF]
J Gen Physiol, 2023 The selective exchange of ions across cellular membranes is a vital biological process. Ca2+-mediated signalling is implicated in a broad array of physiological processes in cells, whilst elevated intracellular concentrations of Ca2+ are cytotoxic.
Ives CM, Thomson NJ, Zachariae U.
europepmc +2 more sources
Osmomechanical-Sensitive TRPV Channels in Mammals
, 2017 Within the transient receptor potential (TRP) superfamily of ion channels (Cosens and Manning, 1969; Montell and Rubin, 1989; Wong et al., 1989; Hardie and Minke, 1992; Zhu et al., 1995), the TRPV subfamily stepped into the limelight in 1997 (Colbert et al., 1997; Caterina et al., 1997), when its founding members, OSM-9 in Caenorhabditis elegans and ...
Moore C, Liedtke WB.
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OSM-9 and OCR-2 TRPV channels are accessorial warm receptors in Caenorhabditis elegans temperature acclimatisation. [PDF]
Sci Rep, 2020 Caenorhabditis elegans (C. elegans) exhibits cold tolerance and temperature acclimatisation regulated by a small number of head sensory neurons, such as the ADL temperature-sensing neurons that express three transient receptor potential vanilloid (TRPV ...
Ohnishi K +6 more
europepmc +2 more sources