Role of the TRPV Channels in the Endoplasmic Reticulum Calcium Homeostasis [PDF]
Cells, 2020 It has been widely established that transient receptor potential vanilloid (TRPV) channels play a crucial role in calcium homeostasis in mammalian cells.
Aurélien Haustrate +2 more
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TRPV Channels in Osteoarthritis: A Comprehensive Review [PDF]
BiomoleculesOsteoarthritis (OA) is a debilitating joint disorder that affects millions of people worldwide. Despite its prevalence, our understanding of the underlying mechanisms remains incomplete.
Changshun Chen +6 more
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Molecular details of ruthenium red pore block in TRPV channels [PDF]
EMBO ReportsTransient receptor potential vanilloid (TRPV) channels play a critical role in calcium homeostasis, pain sensation, immunological response, and cancer progression. TRPV channels are blocked by ruthenium red (RR), a universal pore blocker for a wide array
Ruth A Pumroy +9 more
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TRPV Channels in Mast Cells as a Target for Low-Level-Laser Therapy [PDF]
Cells, 2014 Low-level laser irradiation in the visible as well as infrared range is applied to skin for treatment of various diseases. Here we summarize and discuss effects of laser irradiation on mast cells that leads to degranulation of the cells. This process may
Lina Wang, Di Zhang, Wolfgang Schwarz
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Differential Effects of TRPA and TRPV Channels on Behaviors of Caenorhabditis elegans [PDF]
Journal of Experimental Neuroscience, 2016 TRPA and TRPV ion channels are members of the transient receptor potential (TRP) cation channel superfamily, which mediates various sensory transductions.
Jennifer Thies +3 more
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Expression Profiling of the Transient Receptor Potential Vanilloid (TRPV) Channels 1, 2, 3 and 4 in Mucosal Epithelium of Human Ulcerative Colitis [PDF]
Cells, 2018 The Transient Receptor Potential (TRP) family of selective and non-selective ion channels is well represented throughout the mammalian gastrointestinal track.
Theodoros Rizopoulos +2 more
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Blockade of TRPV channels by intracellular spermine [PDF]
Journal of General Physiology, 2023 The Vanilloid thermoTRP (TRPV1-4) subfamily of TRP channels are involved in thermoregulation, osmoregulation, itch and pain perception, (neuro)inflammation and immune response, and tight control of channel activity is required for perception of noxious ...
Grigory Maksaev +2 more
exaly +4 more sources
TRPC and TRPV Channels’ Role in Vascular Remodeling and Disease [PDF]
International Journal of Molecular Sciences, 2020 Transient receptor potentials (TRPs) are non-selective cation channels that are widely expressed in vascular beds. They contribute to the Ca2+ influx evoked by a wide spectrum of chemical and physical stimuli, both in endothelial and vascular smooth ...
Raquel del Toro Estévez +2 more
exaly +6 more sources
A cooperative knock-on mechanism underpins Ca2+-selective cation permeation in TRPV channels [PDF]
Journal of General Physiology, 2023 The selective exchange of ions across cellular membranes is a vital biological process. Ca2+-mediated signaling is implicated in a broad array of physiological processes in cells, while elevated intracellular concentrations of Ca2+ are cytotoxic.
Neil Thomson +2 more
exaly +4 more sources
Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel [PDF]
Nature Communications, 2016 TRPV are cation channels activated by physical and chemical stimuli. Here the authors show that nicotinamide is a soluble, endogenous agonist for orthologous TRPV channels fromC.
Awani Upadhyay +10 more
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