Evolutionary analyses reveal independent origins of gene repertoires and structural motifs associated to fast inactivation in calcium-selective TRPV channels. [PDF]
Sci Rep, 2020 Essential for calcium homeostasis, TRPV5 and TRPV6 are calcium-selective channels belonging to the transient receptor potential (TRP) gene family. In this study, we investigated the evolutionary history of these channels to add an evolutionary context to
Flores-Aldama L +6 more
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Structure of the full-length TRPV2 channel by cryo-EM [PDF]
Nature Communications, 2016 Transient receptor potential (TRP) proteins are Ca2+-permeable cation channels activated by a range of chemical and physical stimuli. Here the authors describe a cryo-EM structure of the full-length TRPV2 channel that provides insight into the regulation
Kevin W. Huynh +6 more
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Pharmacological or genetic targeting of Transient Receptor Potential (TRP) channels can disrupt the planarian escape response. [PDF]
PLoS ONE, 2019 In response to noxious stimuli, planarians cease their typical ciliary gliding and exhibit an oscillatory type of locomotion called scrunching. We have previously characterized the biomechanics of scrunching and shown that it is induced by specific ...
Ziad Sabry +5 more
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Beyond Hot and Spicy: TRPV Channels and their Pharmacological Modulation
Cellular Physiology and Biochemistry, 2021 Transient receptor potential vanilloid (TRPV) channels are part of the TRP channel superfamily and named after the first identified member TRPV1, that is sensitive to the vanillylamide capsaicin.
Guiscard Seebohm, Julian A. Schreiber
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Human mutations highlight an intersubunit cation-π bond that stabilizes the closed but not open or inactivated states of TRPV channels. [PDF]
Proc Natl Acad Sci U S A, 2019 Significance Transient receptor potential (TRP) channels are key cation channels that respond to thermal, chemical, electric, or mechanical stimuli. There are >60 mutations known in TrpV4 that cause defects in bone or neural development.
Teng J, Anishkin A, Kung C, Blount P.
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Differential Effects of TRPA and TRPV Channels on Behaviors of
Journal of Experimental Neuroscience, 2016 TRPA and TRPV ion channels are members of the transient receptor potential (TRP) cation channel superfamily, which mediates various sensory transductions.
Jennifer Thies +3 more
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Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK [PDF]
Cell Metabolism, 2019 Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how aldolase transmits lack of occupancy by FBP to AMPK activation remains unclear.
Changchuan Xie +34 more
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Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel
Nature Communications, 2016 TRPV are cation channels activated by physical and chemical stimuli. Here the authors show that nicotinamide is a soluble, endogenous agonist for orthologous TRPV channels fromC.
Awani Upadhyay +10 more
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Integrative genomic, phylogenetic, and transcriptomic analyses reveal temperature-responsive transient receptor potential (TRP) genes in Pacific abalone Haliotis discus hannai [PDF]
BMC Ecology and EvolutionTemperature profoundly influences the physiology, survival, and distribution of marine ectotherms, including mollusks. Transient receptor potential (TRP) channels are conserved thermosensory proteins in metazoans, yet their evolutionary diversification ...
Mi Ae Kim, Young Chang Sohn
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Thermosensory TRPV Heterotetramers Drive Seasonal Polyphenism: Molecular Basis of CcIav/CcNan‐PKCα‐AKH/AKHR Signaling in Pear Psyllid Morph Transition [PDF]
Advanced ScienceTemperature critically governs seasonal polyphenism, shaping species distribution and invasion dynamics. Although vanilloid‐type transient receptor potential (TRPV) channels are conserved thermal sensors, their mechanistic role in orchestrating seasonal ...
Jianying Li +6 more
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