Pathway-dependent cold activation of heat-responsive TRPV channels [PDF]
Scientific ReportsThe homotetrameric thermosensitive transient receptor potential vanilloid 1–4 (TRPV1-4) channels in sensory neurons are highly responsive to environmental heat stimuli.
Guangyu Wang
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PLoS ONE, 2017 The activation of mast cells (MC) is part of the innate and adaptive immune responses and depends on Ca2+ entry across the plasma membrane, leading to the release of preformed inflammatory mediators by degranulation or by de novo synthesis.
A Solís-López +7 more
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BRET-Based Approaches for Ion Channels: Emerging Applications and Future Directions. [PDF]
Arch Pharm (Weinheim)Bioluminescence resonance energy transfer (BRET) is a versatile method for studying ligand–protein interactions. Its compatibility with high‐throughput screening and real‐time kinetics has made it widely used in drug discovery. Here, we summarize recent applications of BRET‐based methods for studying ligand binding to ion channels, highlighting key ...
Kock N +6 more
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Women with a history of gestational diabetes mellitus have preserved sensory nerve-mediated dilatation in the cutaneous microvasculature. [PDF]
Exp PhysiolAbstract Women with a history of gestational diabetes mellitus (GDM) have a greater risk of developing type 2 diabetes mellitus and cardiovascular disease than healthy control (HC) women who had an uncomplicated pregnancy. Microvascular endothelial dysfunction, mediated by reduced nitric oxide (NO)‐dependent mechanisms, persists after GDM.
Maurer GS +3 more
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Calcium binding and permeation in TRPV channels: Insights from molecular dynamics simulations [PDF]
Journal of General Physiology, 2023 Chen Song, Chunhong Liu, Lingfeng Xue
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Integrative genomic, phylogenetic, and transcriptomic analyses reveal temperature-responsive transient receptor potential (TRP) genes in Pacific abalone Haliotis discus hannai [PDF]
BMC Ecology and EvolutionTemperature profoundly influences the physiology, survival, and distribution of marine ectotherms, including mollusks. Transient receptor potential (TRP) channels are conserved thermosensory proteins in metazoans, yet their evolutionary diversification ...
Mi Ae Kim, Young Chang Sohn
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Structural insights into the gating mechanisms of TRPV channels [PDF]
Cell Calcium, 2020 Vera Moiseenkova-Bell +2 more
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Endosomal MrGPRX1 signaling sensitizes TRPV1 to enhance itch [PDF]
Frontiers in Molecular NeuroscienceG protein-coupled receptors (GPCRs) and TRPV (transient receptor potential vanilloid) channels are crucial for signal transduction in physiological processes, including neurotransmission, pain, and itch.
Paz Duran +14 more
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Structural insight into the assembly of TRPV channels. [PDF]
Structure, 2014 SummaryTransient receptor potential (TRP) proteins are a large family of polymodal nonselective cation channels. The TRP vanilloid (TRPV) subfamily consists of six homologous members with diverse functions.
Huynh KW +5 more
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A co-operative knock-on mechanism underpins Ca 2+ -selective cation permeation in TRPV channels [PDF]
, 2022 The selective exchange of ions across cellular membranes is a vital biological process. Ca2+-mediated signalling is implicated in a broad array of physiological processes in cells, whilst elevated intracellular concentrations of Ca2+ are cytotoxic.
Ives CM, Thomson NJ, Zachariae U.
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