Results 71 to 80 of about 15,128 (217)

TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice [PDF]

, 2017
The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated.
Chiurchiù, Valerio, Giustizieri, Michela, Leuti, Alessandro, Lombardi, Marta, Maccarrone, Mauro, Marinelli, Sara, Marinelli, Silvia, Marrone, Maria Cristina, Mattioli, Marzia, Morabito, Annunziato, Murana, Emanuele, Oddi, Sergio, Piomelli, Daniele, Ragozzino, Davide Antonio, Riganti, Loredana, Totaro, Antonio, Verderio, Claudia   +16 more
core   +3 more sources

Transient Hyperparathyroidism and Severe Intrauterine Osteopenia Linked to Novel Homozygous TRPV6 Deletion

Clinical Endocrinology, EarlyView.
ABSTRACT Context Placental calcium (Ca2+) transport is essential for foetal bone mineralisation and development, as well as for Ca2+ homoeostasis. Rare mutations in transient receptor potential vanilloid (TRPV) 6 of the infant cause insufficient maternal‐foetal Ca2+ transport through the placenta.
Teodora Grigore, Quinty Leusink, Femke Latta, Bram van der Eerden, Paul de Laat, Danielle van der Kaay, Joost Hoenderop   +6 more
wiley   +1 more source

Drosophila TRPN(=NOMPC) channel localizes to the distal end of mechanosensory cilia.

PLoS ONE, 2010
BackgroundA TRPN channel protein is essential for sensory transduction in insect mechanosensory neurons and in vertebrate hair cells. The Drosophila TRPN homolog, NOMPC, is required to generate mechanoreceptor potentials and currents in tactile bristles.
Jeongmi Lee, Sungjin Moon, Yoonseok Cha, Yun Doo Chung   +3 more
doaj   +1 more source

Stereotypical escape behavior in Caenorhabditis elegans allows quantification of nociceptive stimuli levels

, 2016
Experiments of pain with human subjects are difficult, subjective, and ethically constrained. Since the molecular mechanisms of pain transduction are reasonably conserved among different species, these problems are partially solved by the use of animal ...
Leung, Kawai, Mohammadi, Aylia, Nemenman, Ilya, Ryu, William S.   +3 more
core   +2 more sources

Stimulation of 3D osteogenesis by mesenchymal stem cells using a nanovibrational bioreactor [PDF]

, 2017
Bone grafts are one of the most commonly transplanted tissues. However, autologous grafts are in short supply, and can be associated with pain and donor-site morbidity.
Biggs, Manus J. P., Blackburn, Gavin, Burgess, Karl, Childs, Peter G., Curtis, Adam S. G., Dalby, Matthew J., González-García, Cristina, Jayawarna, Vineetha, Orapiriyakul, Wich, Pemberton, Gabriel D., Reid, Stuart, Salmerón-Sánchez, Manuel, Thomas, Dilip, Tsimbouri, Penelope M., Vallejo-Giraldo, Catalina, Yang, Jingli   +15 more
core   +2 more sources

Interpretable machine learning models based on CMR radiomics for predicting left ventricular diastolic dysfunction in patients with metabolic‐associated steatotic liver disease and type 2 diabetes mellitus

Journal of Diabetes Investigation, EarlyView.
We developed an interpretable machine learning (ML) model combining cardiac magnetic resonance (CMR) radiomics and clinical data to assess left ventricular diastolic dysfunction (LVDD) risk in metabolic‐associated steatotic liver disease (MASLD)/type 2 diabetes mellitus (T2DM) patients, enabling proactive treatment.
Jinying Xia, Shaoyi Leng, Bin Xu, Guang Jin, Jianhui Li, Mingchen Zhang, Danzhen Yao, Ruiting Shen, Qifeng Hua   +8 more
wiley   +1 more source

Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity

eLife, 2019
The Transient Receptor Potential Vanilloid 1 (TRPV) channel is activated by an array of stimuli, including heat and vanilloid compounds. The TRPV1 homologues TRPV2 and TRPV3 are also activated by heat, but sensitivity to vanilloids and many other ...
Feng Zhang, Kenton Jon Swartz, Andres Jara-Oseguera   +2 more
doaj   +1 more source

Impaired Duodenal Palmitoylethanolamide Release Underlies Acid-Induced Mast Cell Activation in Functional DyspepsiaSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Acid hypersensitivity is claimed to be a symptomatic trigger in functional dyspepsia (FD); however, the neuroimmune pathway(s) and the mediators involved in this process have not been investigated systematically ...
Giovanni Sarnelli, Marcella Pesce, Luisa Seguella, Jie Lu, Eleonora Efficie, Jan Tack, Fatima Domenica Elisa De Palma, Alessandra D’Alessandro, Giuseppe Esposito   +8 more
doaj   +1 more source

Non‐Pharmacological Interventions for Cough in Patients With Lung Cancer: A Systematic Review and Meta‐Analysis

Journal of Clinical Nursing, EarlyView.
ABSTRACT Background Cough, a prevalent and debilitating symptom of lung cancer, remains poorly managed. Accumulating evidence on non‐pharmacological interventions for lung cancer cough necessitates systematic evaluation to assess their efficacy. Aim To synthesise evidence on non‐pharmacological interventions for managing cough in lung cancer patients ...
Mengyao Cao, Xueyan Cheng, Victor Ho‐fun Lee, Chia‐Chin Lin, Denise Shuk Ting Cheung   +4 more
wiley   +1 more source

Thermosensation and the TRPV channel in Rhodnius prolixus

Journal of Insect Physiology, 2015
The thermal sense of triatomine bugs, vectors of Chagas disease, is unique among insects. Not only do these bugs exhibit the highest sensitivity to heat known in any animal up to date, but they can also perceive the infrared radiation emitted by the body of their warm-blooded hosts.
Zermoglio, Paula F., Latorre-Estivalis, Jose Manuel, Crespo, José E., Lorenzo, Marcelo Gustavo, Lazzari, Claudio R.   +4 more
openaire   +5 more sources