Results 51 to 60 of about 15,128 (217)

Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel [PDF]

, 2014
The TRPV4 calcium-permeable cation channel plays important physiological roles in osmosensation, mechanosensation, cell barrier formation, and bone homeostasis. Recent studies reported that mutations in TRPV4, including some in its ankyrin repeat domain (
Gaudet, Rachelle, Inada, Hitoshi, Procko, Erik, Sotomayor, Marcos   +3 more
core   +2 more sources

Expression of trpv channels during Xenopus laevis embryogenesis [PDF]

Gene Expression Patterns, 2018
Transient receptor potential (TRP) cation channel genes code for an extensive family of conserved proteins responsible for a variety of physiological processes, including sensory perception, ion homeostasis, and chemical signal transduction. The TRP superfamily consists of seven subgroups, one of which is the transient receptor potential vanilloid ...
Chen Dong, Sudip Paudel, Nana Yaa Amoh, Margaret S. Saha   +3 more
openaire   +2 more sources

Unification of gauge couplings and the tau neutrino mass in Supergravity without R-parity [PDF]

, 1999
Minimal R-parity violating supergravity predicts a value for $alpha_s(M_Z)$ smaller than in the case with conserved R-parity, and therefore closer to the experimental world average.
Ackerstaff, Akeroyd, Akeroyd, Allanach, Antoniadis, Aulakh, Bagger, Banks, Barate, Barbieri, Barbieri, Barger, Barger, Barger, Bastero-Gil, Bednyakov, Bisset, Capper, Carena, Caso, Chun, Davidson, Davidson, Davidson, de Campos, de Carlos, de Carlos, Dienes, Dı́az, Dı́az, Dı́az, Dı́az, Einhorn, Ellis, Faessler, Faraggi, Ferrandis, Fornengo, Fornengo, Fukuda, Fukuda, Fukuda, Gonzalez-Garcia, Gonzalez-Garcia, Gonzalez-Garcia, Gonzalez-Garcia, Gorishny, Gorishny, Hall, Hall, Hempfling, Hill, J Ferrandis, J.C Romão, J.W.F Valle, Jones, Joshipura, Joshipura, Joshipura, Kong, Langacker, Langacker, Langacker, Lee, Lee, M.A Dı́az, Machacek, Machacek, Machacek, Martin, Martin, Masiero, Mukhopadhyaya, Nardi, Nath, Nilles, Nowakowski, Romao, Romao, Romao, Ross, Santamaria, Santamaria, Shafi, Shifman, Shifman, Siegel, Smirnov, Stirling, Tarasov, Tarrach, Valle   +91 more
core   +2 more sources

The membrane-associated transient receptor potential vanilloid channel is the central heat shock receptor controlling the cellular heat shock response in epithelial cells. [PDF]

PLoS ONE, 2013
The heat shock response (HSR) is a highly conserved molecular response to various types of stresses, including heat shock, during which heat-shock proteins (Hsps) are produced to prevent and repair damages in labile proteins and membranes.
Zohar Bromberg, Pierre Goloubinoff, Younousse Saidi, Yoram George Weiss   +3 more
doaj   +1 more source

TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel [PDF]

, 2014
Transient receptor potential (TRP) channels, a superfamily of ion channels, can be divided into 7 subfamilies, including TRPV, TRPC, TRPP, and 4 others. Functional TRP channels are tetrameric complexes consisting of 4 pore-forming subunits.
Birnbaumer, Lutz, Du, Juan, Huang, Yu, Ma, Xin, Shen, Bing, Yao, Xiaoqiang   +5 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Homo- and heteromeric assembly of TRPV channel subunits [PDF]

Journal of Cell Science, 2005
The vanilloid receptor-related TRP channels (TRPV1-6) mediate thermosensation, pain perception and epithelial Ca2+ entry. As the specificity of TRPV channel heteromerization and determinants governing the assembly of TRPV subunits were largely elusive, we investigated the TRPV homo- and heteromultimerization. To analyze the assembly of TRPV subunits in
Nicole, Hellwig, Nadine, Albrecht, Christian, Harteneck, Günter, Schultz, Michael, Schaefer   +4 more
openaire   +2 more sources

Molecular Physiology of TRPV Channels: Controversies and Future Challenges

Annual Review of Physiology, 2023
The ability to detect stimuli from the environment plays a pivotal role in our survival. The molecules that allow the detection of such signals include ion channels, which are proteins expressed in different cells and organs. Among these ion channels, the transient receptor potential (TRP) family responds to the presence of diverse chemicals ...
Tamara, Rosenbaum, León D, Islas
openaire   +2 more sources

A functional nuclear localization sequence in the C. elegans TRPV channel OCR-2. [PDF]

PLoS ONE, 2011
The ability to modulate gene expression in response to sensory experience is critical to the normal development and function of the nervous system. Calcium is a key activator of the signal transduction cascades that mediate the process of translating a ...
Meredith J Ezak, Denise M Ferkey
doaj   +1 more source

Capsazepine antagonizes TRPV1 activation induced by thermal and osmotic stimuli in human odontoblast-like cells

Journal of Oral Biology and Craniofacial Research, 2023
Objectives: Dental pain, which is the main reason for patients consulting dentists, is classified as a public health concern. The study of cellular and molecular mechanisms contributing to pain is a fundamental element for developing new analgesics.
Lilia Jadith Bernal-Cepeda, Myriam L. Velandia-Romero, Jaime E. Castellanos   +2 more
doaj   +1 more source