Results 41 to 50 of about 15,128 (217)
Frontiers in Immunology, 2022 BackgroundThe transient receptor potential vanilloid (TRPV) channels family, TRPV1-6, has been identified to profoundly affect a wide spectrum of pathological processes in various cancers. However, the biological function and prognostic value of TRPVs in
Yuxiong Jiang +8 more
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Heat Activation of TRPV Channels [PDF]
Biophysical Journal, 2012 Activation of TRPV1-4 channels is exquisitely heat-sensitive due to large and balanced changes in entropy and enthalpy. Identification of channel structures that underlie these changes is thus the prerequisite for understanding the molecular mechanism of heat activation. We approach this goal through a combination of methods.
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Cells, 2018 The Transient Receptor Potential (TRP) family of selective and non-selective ion channels is well represented throughout the mammalian gastrointestinal track.
Theodoros Rizopoulos +2 more
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The Anaphase-Promoting Complex (APC) ubiquitin ligase affects chemosensory behavior in \u3cem\u3eC. elegans\u3c/em\u3e [PDF]
, 2016 The regulation of fundamental aspects of neurobiological function has been linked to the ubiquitin signaling system (USS), which regulates the degradation and activity of proteins and is catalyzed by E1, E2, and E3 enzymes. The Anaphase-Promoting Complex
Jennings, Alexandra K. +2 more
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PLoS ONE, 2017 The activation of mast cells (MC) is part of the innate and adaptive immune responses and depends on Ca2+ entry across the plasma membrane, leading to the release of preformed inflammatory mediators by degranulation or by de novo synthesis.
A Solís-López +7 more
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Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK [PDF]
, 2019 Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how aldolase transmits lack of occupancy by FBP to AMPK activation remains unclear.
Changchuan Xie +34 more
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Role of TRPV receptors in respiratory diseases
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007 Transient receptor potential vanilloid type channels (TRPVs) are expressed in several cell types in human and animal lungs. Increasing evidence has demonstrated important roles of these cation channels, particularly TRPV1 and TRPV4, in the regulation of airway function.
Jia, Yanlin, Lee, Lu-Yuan
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Scientific Reports, 2021 Stronger contractility and smaller bladder capacity are common symptoms in ketamine cystitis (KC). This study investigates the association between expression levels of transient receptor potential cation channel subfamily V (TRPV) proteins and the ...
Hsueh-Hui Yang +5 more
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Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations. [PDF]
, 2012 The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sensitive ion channel. Although chemical activation and heat activation of TRPV1 elicit similar pungent, painful sensation, the molecular mechanism underlying ...
Cao, Xu +5 more
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Enhancement of immune cytokines and splenic CD4+ T cells by electroacupuncture at ST36 acupoint of SD rats. [PDF]
PLoS ONE, 2017 Electroacupuncture at the ST36 acupoint can enhance the body's immune function. However, the mechanism for this enhancement has not been fully described.
Longyun Chen +7 more
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