Results 21 to 30 of about 10,867 (203)
PLoS ONE, 2017 The activation of mast cells (MC) is part of the innate and adaptive immune responses and depends on Ca2+ entry across the plasma membrane, leading to the release of preformed inflammatory mediators by degranulation or by de novo synthesis.
A Solís-López +7 more
doaj +2 more sources
Thermosensory TRPV Heterotetramers Drive Seasonal Polyphenism: Molecular Basis of CcIav/CcNan‐PKCα‐AKH/AKHR Signaling in Pear Psyllid Morph Transition [PDF]
Advanced ScienceTemperature critically governs seasonal polyphenism, shaping species distribution and invasion dynamics. Although vanilloid‐type transient receptor potential (TRPV) channels are conserved thermal sensors, their mechanistic role in orchestrating seasonal ...
Jianying Li +6 more
doaj +2 more sources
BRET-Based Approaches for Ion Channels: Emerging Applications and Future Directions. [PDF]
Arch Pharm (Weinheim)Bioluminescence resonance energy transfer (BRET) is a versatile method for studying ligand–protein interactions. Its compatibility with high‐throughput screening and real‐time kinetics has made it widely used in drug discovery. Here, we summarize recent applications of BRET‐based methods for studying ligand binding to ion channels, highlighting key ...
Kock N +6 more
europepmc +2 more sources
Acta bio-medica : Atenei Parmensis, 2009 : Vanilloids are natural molecules identified in a plethora of foods normally ingested through the diet. They mediate apoptosis through a direct pathway (independent of TRPV-1, the receptor for vanilloids) and through an indirect pathway, i.e., thanks to
Ziglioli, Francesco +5 more
core +3 more sources
TRPV channels as temperature sensors [PDF]
Cell Calcium, 2003 The past year has seen a doubling in the number of heat-sensitive ion channels to six, and four of these channels are from the TRPV family. These channels characteristically have Q(10) values of >10 above the thermal threshold, very different from the Q(10) values of 1.5-2.0 seen in most ion channels.
Christopher D, Benham +2 more
openaire +4 more sources
Frontiers in Molecular Neuroscience, 2022 Acupuncture is a common complementary and alternative therapy around the world, but its mechanism remains still unclear. In the past decade, some studies indicated that transient receptor potential vanilloid (TRPV) channels play a great role in the ...
Dan Luo +10 more
doaj +1 more source
Transient Receptor Potential Vanilloid (TRPV) channels: Basal Properties and physiological potential [PDF]
, 2022 Transient receptor potential vanilloid (TRPV) channels are TRP homologs and have been classified into six subfamilies. They are unique mediators of sensory signals with multiple physiological effects and are potential targets for developing new therapies
Sasase, Tomohiko +2 more
core +1 more source
Frontiers in Medicine, 2021 The battle against the new coronavirus that continues to kill millions of people will be still long. Novel strategies are demanded to control infection, mitigate symptoms and treatment of COVID-19. This is even more imperative given the long sequels that
Filippo Liviero +3 more
doaj +1 more source
Evaluating methods and protocols of ferritin-based magnetogenetics
iScience, 2021 Summary: FeRIC (Ferritin iron Redistribution to Ion Channels) is a magnetogenetic technique that uses radiofrequency (RF) alternating magnetic fields to activate the transient receptor potential channels, TRPV1 and TRPV4, coupled to cellular ferritins ...
Miriam Hernández-Morales +3 more
doaj +1 more source
Pan-Cancer Analysis Reveals Genomic and Clinical Characteristics of TRPV Channel-Related Genes
Frontiers in Oncology, 2022 BackgroundTransient Receptor Potential channels (TRPs), a class of ion channels, were first described two decades ago. Many TRP family members are major participants in nociception and integration of heat and pain signals.
Xiaoxuan Wang +9 more
doaj +1 more source