Results 11 to 20 of about 10,867 (203)

TRPV Channels in Osteoarthritis: A Comprehensive Review

Biomolecules
Osteoarthritis (OA) is a debilitating joint disorder that affects millions of people worldwide. Despite its prevalence, our understanding of the underlying mechanisms remains incomplete.
Bin Geng, Chen Rongjin, Changshun Chen   +2 more
exaly   +6 more sources

Role of the TRPV Channels in the Endoplasmic Reticulum Calcium Homeostasis

Cells, 2020
It has been widely established that transient receptor potential vanilloid (TRPV) channels play a crucial role in calcium homeostasis in mammalian cells.
V'Yacheslav Lehen'Kyi, Aurélien Haustrate, V’Yacheslav Lehen’Kyi   +2 more
exaly   +4 more sources

Molecular details of ruthenium red pore block in TRPV channels

EMBO Reports
Transient receptor potential vanilloid (TRPV) channels play a critical role in calcium homeostasis, pain sensation, immunological response, and cancer progression. TRPV channels are blocked by ruthenium red (RR), a universal pore blocker for a wide array
Vera Moiseenkova-Bell, Ruth Pumroy, Edwin Fluck   +2 more
exaly   +3 more sources

Integrative analysis of TRPV family to prognosis and immune infiltration in renal clear cell carcinoma

Channels, 2022
The transient receptor potential vanilloid (TRPV) family has been preliminarily discovered to play an important role in various cancers, including clear cell renal cell carcinoma (ccRCC), which is closely associated with immune infiltration. However, the
Zixuan Gong, Jiaheng Xie, Liang Chen, Qikai Tang, Yiming Hu, Aiming Xu, Zengjun Wang   +6 more
doaj   +2 more sources

Differential Effects of TRPA and TRPV Channels on Behaviors of

Journal of Experimental Neuroscience, 2016
TRPA and TRPV ion channels are members of the transient receptor potential (TRP) cation channel superfamily, which mediates various sensory transductions.
Jennifer Thies, Vanessa Neutzler, Fidelma O'leary, He Liu   +3 more
doaj   +2 more sources

Structural Insight into the Assembly of TRPV Channels [PDF]

Biophysical Journal, 2014
SummaryTransient receptor potential (TRP) proteins are a large family of polymodal nonselective cation channels. The TRP vanilloid (TRPV) subfamily consists of six homologous members with diverse functions.
Stewart, Phoebe L., Huynh, Kevin W., Holdaway, Heather, Huynh, Kevin, Stewart, Phoebe, Holdaway, Heather A., Cohen, Matthew, Chakrapani, Sudha, Cohen, Matthew R., Moiseenkova-Bell, Vera Y., Moiseenkova-Bell, Vera   +10 more
core   +5 more sources

Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel [PDF]

Nature Communications, 2016
TRPV are cation channels activated by physical and chemical stimuli. Here the authors show that nicotinamide is a soluble, endogenous agonist for orthologous TRPV channels fromC.
Awani Upadhyay, Aditya Pisupati, Timothy Jegla, Matt Crook, Keith J. Mickolajczyk, Matthew Shorey, Laura E. Rohan, Katherine A. Billings, Melissa M. Rolls, William O. Hancock, Wendy Hanna-Rose   +10 more
doaj   +2 more sources

Pan-cancer analyses of clinical prognosis, immune infiltration, and immunotherapy efficacy for TRPV family using multi-omics data

Heliyon, 2023
Background: Transient receptor potential cation channel subfamily V (TRPV) play an essential in cancer initiation, progression, and treatment. TRPV expression alteration are shown relate to multiple cancers prognosis and treatment of cancers but are less-
Chong Shen, Chong Fu, Yong Suo, Kai Li, Zhe Zhang, Shaobo Yang, Yu Zhang, Yuda Lin, Zhi Li, Zhouliang Wu, Shiwang Huang, Houyuan Chen, Zhenqian Fan, Hailong Hu   +13 more
doaj   +2 more sources

Dynamic evolution of transient receptor potential vanilloid (TRPV) ion channel family with numerous gene duplications and losses [PDF]

Frontiers in Endocrinology, 2022
The transient receptor potential vanilloid (TRPV) ion channel family is involved in multiple sensory and physiological functions including thermosensing and temperature-dependent neuroendocrine regulation.
Marina Morini, Marina Morini, Christina A. Bergqvist, Juan F. Asturiano, Dan Larhammar, Sylvie Dufour   +5 more
doaj   +2 more sources

Role of TRPV receptors in respiratory diseases [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007
Transient receptor potential vanilloid type channels (TRPVs) are expressed in several cell types in human and animal lungs. Increasing evidence has demonstrated important roles of these cation channels, particularly TRPV1 and TRPV4, in the regulation of ...
Lee, Lu-Yuan, Lu-Yuan Lee, Yanlin Jia, Jia, Yanlin   +3 more
core   +4 more sources