Results 11 to 20 of about 15,128 (217)
Heliyon, 2023 Background: Transient receptor potential cation channel subfamily V (TRPV) play an essential in cancer initiation, progression, and treatment. TRPV expression alteration are shown relate to multiple cancers prognosis and treatment of cancers but are less-
Chong Shen +13 more
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Channels, 2022 The transient receptor potential vanilloid (TRPV) family has been preliminarily discovered to play an important role in various cancers, including clear cell renal cell carcinoma (ccRCC), which is closely associated with immune infiltration. However, the
Zixuan Gong +6 more
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TRPV Protein Family—From Mechanosensing to Cancer Invasion [PDF]
Biomolecules, 2021 Biophysical cues from the cellular microenvironment are detected by mechanosensitive machineries that translate physical signals into biochemical signaling cascades. At the crossroads of extracellular space and cell interior are located several ion channel families, including TRP family proteins, that are triggered by mechanical stimuli and drive ...
Kärki, Tytti, Tojkander, Sari
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TRPV channels as temperature sensors [PDF]
Cell Calcium, 2003 The past year has seen a doubling in the number of heat-sensitive ion channels to six, and four of these channels are from the TRPV family. These channels characteristically have Q(10) values of >10 above the thermal threshold, very different from the Q(10) values of 1.5-2.0 seen in most ion channels.
Christopher D, Benham +2 more
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Frontiers in Medicine, 2021 The battle against the new coronavirus that continues to kill millions of people will be still long. Novel strategies are demanded to control infection, mitigate symptoms and treatment of COVID-19. This is even more imperative given the long sequels that
Filippo Liviero +3 more
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Evaluating methods and protocols of ferritin-based magnetogenetics
iScience, 2021 Summary: FeRIC (Ferritin iron Redistribution to Ion Channels) is a magnetogenetic technique that uses radiofrequency (RF) alternating magnetic fields to activate the transient receptor potential channels, TRPV1 and TRPV4, coupled to cellular ferritins ...
Miriam Hernández-Morales +3 more
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Pathway-dependent cold activation of heat-responsive TRPV channels
Scientific ReportsThe homotetrameric thermosensitive transient receptor potential vanilloid 1–4 (TRPV1-4) channels in sensory neurons are highly responsive to environmental heat stimuli.
Guangyu Wang
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Pan-Cancer Analysis Reveals Genomic and Clinical Characteristics of TRPV Channel-Related Genes
Frontiers in Oncology, 2022 BackgroundTransient Receptor Potential channels (TRPs), a class of ion channels, were first described two decades ago. Many TRP family members are major participants in nociception and integration of heat and pain signals.
Xiaoxuan Wang +9 more
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Ligand-Binding Sites in Vanilloid-Subtype TRP Channels
Frontiers in Pharmacology, 2022 Vanilloid-subfamily TRP channels TRPV1-6 play important roles in various physiological processes and are implicated in numerous human diseases. Advances in structural biology, particularly the “resolution revolution” in cryo-EM, have led to breakthroughs
Maria V. Yelshanskaya +1 more
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Human podocytes express functional thermosensitive TRPV channels [PDF]
British Journal of Pharmacology, 2017 Background and PurposeHeat‐sensitive transient receptor potential vanilloid (TRPV) channels are expressed in various epithelial tissues regulating, among else, barrier functions. Their expression is well established in the distal nephron; however, we have no data about their presence in podocytes.
Lídia Ambrus +4 more
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