Capsazepine affects thermal preferences of the American cockroach (Blattodea: Blattidae)
European Journal of Entomology, 2016 Capsazepine is a competitive antagonist of capsaicin, a TRPV1 agonist responsible for the spicy taste of pepper. TRPV1 agonists and antagonists are known to affect mammalian body temperature, but their action on thermoregulation in insects is poorly ...
Justyna MALISZEWSKA, Eugenia TĘGOWSKA
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Ligand-Binding Sites in Vanilloid-Subtype TRP Channels
Frontiers in Pharmacology, 2022 Vanilloid-subfamily TRP channels TRPV1-6 play important roles in various physiological processes and are implicated in numerous human diseases. Advances in structural biology, particularly the “resolution revolution” in cryo-EM, have led to breakthroughs
Maria V. Yelshanskaya +1 more
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A cooperative knock-on mechanism underpins Ca2+-selective cation permeation in TRPV channels [PDF]
, 2023 The selective exchange of ions across cellular membranes is a vital biological process. Ca2+-mediated signaling is implicated in a broad array of physiological processes in cells, while elevated intracellular concentrations of Ca2+ are cytotoxic.
Ives, Callum M.; id_orcid +2 more
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TRPV1 in brain is involved in acetaminophen-induced antinociception.
PLoS ONE, 2010 Acetaminophen, the major active metabolite of acetanilide in man, has become one of the most popular over-the-counter analgesic and antipyretic agents, consumed by millions of people daily. However, its mechanism of action is still a matter of debate. We
Christophe Mallet +6 more
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Pharmaceutics, 2021 The gliovascular unit (GVU) is composed of the brain microvascular endothelial cells forming blood–brain barrier and the neighboring surrounding “mural” cells (e.g., pericytes) and astrocytes.
Huilong Luo +2 more
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TRPV channels activation induces cell death in Human Pancreatic Ductal Adenocarcinoma cell lines
, 2022 Introduction Pancreatic Ductal Adenocarcinoma is one of the most aggressive and lethal malignancy. The main therapeutic strategy is surgical resection followed by adjuvant chemotherapy, but only 10-20-% of patients have a resectable form, while if it is
G. Santoni +7 more
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Tradução Oral à Prima Vista na formação do intérprete: considerações pedagógicas
Domínios de Lingu@gem, 2017 A Tradução Oral à Prima Vista (TrPV) é um elemento de relevância para a formação do intérprete e um componente essencial para o desempenho do futuro profissional em muitos ambientes de atuação.
Gloria Regina Loreto Sampaio
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Specific Polyunsaturated Fatty Acids Drive TRPV-Dependent Sensory Signaling In Vivo [PDF]
, 2004 A variety of lipid and lipid-derived molecules can modulate TRP cation channel activity, but the identity of the lipids that affect TRP channel function in vivo is unknown. Here, we use genetic and behavioral analysis in the nematode C.
Kahn-Kirby, Amanda H +19 more
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Cellular mechanism underlying formaldehyde-stimulated Cl- secretion in rat airway epithelium. [PDF]
PLoS ONE, 2013 BACKGROUND: Recent studies suggest that formaldehyde (FA) could be synthesized endogeneously and transient receptor potential (TRP) channel might be the sensor of FA. However, the physiological significance is still unclear.
Yu-Li Luo +6 more
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Role of Transient Receptor Potential Vanilloid Channels (TRPV) in Cancer: Narrative Review [PDF]
, 2022 Cancer is the leading cause of death worldwide, accounting for nearly 10 million deaths in 2020. It leads cancer to being a global problem. Cancer can modify calcium signaling networks by altering the expression and function of cation channels, pumps ...
HAIKAL, Muhamad Adly
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