TRPV Channels in Osteoarthritis: A Comprehensive Review
BiomoleculesOsteoarthritis (OA) is a debilitating joint disorder that affects millions of people worldwide. Despite its prevalence, our understanding of the underlying mechanisms remains incomplete.
Changshun Chen
exaly +5 more sources
Pharmacological or genetic targeting of Transient Receptor Potential (TRP) channels can disrupt the planarian escape response. [PDF]
PLoS ONE, 2019 In response to noxious stimuli, planarians cease their typical ciliary gliding and exhibit an oscillatory type of locomotion called scrunching. We have previously characterized the biomechanics of scrunching and shown that it is induced by specific ...
Ziad Sabry +5 more
doaj +5 more sources
Role of the TRPV Channels in the Endoplasmic Reticulum Calcium Homeostasis
Cells, 2020 It has been widely established that transient receptor potential vanilloid (TRPV) channels play a crucial role in calcium homeostasis in mammalian cells.
V'yacheslav Lehen'kyi
exaly +3 more sources
Frontiers in Endocrinology, 2022 The transient receptor potential vanilloid (TRPV) ion channel family is involved in multiple sensory and physiological functions including thermosensing and temperature-dependent neuroendocrine regulation.
Marina Morini, Sylvie Dufour
exaly +3 more sources
Structure of the full-length TRPV2 channel by cryo-EM [PDF]
Nature Communications, 2016 Transient receptor potential (TRP) proteins are Ca2+-permeable cation channels activated by a range of chemical and physical stimuli. Here the authors describe a cryo-EM structure of the full-length TRPV2 channel that provides insight into the regulation
Kevin W. Huynh +6 more
doaj +3 more sources
Thermosensory TRPV Heterotetramers Drive Seasonal Polyphenism: Molecular Basis of CcIav/CcNan‐PKCα‐AKH/AKHR Signaling in Pear Psyllid Morph Transition [PDF]
Advanced ScienceTemperature critically governs seasonal polyphenism, shaping species distribution and invasion dynamics. Although vanilloid‐type transient receptor potential (TRPV) channels are conserved thermal sensors, their mechanistic role in orchestrating seasonal ...
Jianying Li +6 more
doaj +2 more sources
Airway expression of Transient Receptor Potential (TRP) Vanniloid-1 and Ankyrin-1 channels is not increased in patients with Idiopathic Pulmonary Fibrosis. [PDF]
PLoS ONE, 2017 Dry cough is a common symptom described in patients with Idiopathic Pulmonary Fibrosis (IPF) and impairs quality of life. The exact mechanisms causing cough in IPF remain unclear, however evidence suggests altered cough neurophysiology and sensitisation ...
Nicola-Xan Hutchinson +3 more
doaj +5 more sources
Integrative genomic, phylogenetic, and transcriptomic analyses reveal temperature-responsive transient receptor potential (TRP) genes in Pacific abalone Haliotis discus hannai [PDF]
BMC Ecology and EvolutionTemperature profoundly influences the physiology, survival, and distribution of marine ectotherms, including mollusks. Transient receptor potential (TRP) channels are conserved thermosensory proteins in metazoans, yet their evolutionary diversification ...
Mi Ae Kim, Young Chang Sohn
doaj +2 more sources
Molecular details of ruthenium red pore block in TRPV channels
EMBO ReportsTransient receptor potential vanilloid (TRPV) channels play a critical role in calcium homeostasis, pain sensation, immunological response, and cancer progression. TRPV channels are blocked by ruthenium red (RR), a universal pore blocker for a wide array
Tabea Caroline Fricke +2 more
exaly +2 more sources
Frontiers in Molecular Neuroscience, 2022 Acupuncture is a common complementary and alternative therapy around the world, but its mechanism remains still unclear. In the past decade, some studies indicated that transient receptor potential vanilloid (TRPV) channels play a great role in the ...
Dan Luo +10 more
doaj +1 more source