Results 91 to 100 of about 15,128 (217)

A molecular determinant of phosphoinositide affinity in mammalian TRPV channels [PDF]

Scientific Reports, 2016
AbstractPhosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is an important cofactor for ion channels. Affinity for this lipid is a major determinant of channel inhibition by depletion of PI(4,5)P2 upon phospholipase C (PLC) activation. Little is known about what determines PI(4,5)P2 affinity in mammalian ion channels.
Phanindra Velisetty, Istvan Borbiro, Marina A. Kasimova, Luyu Liu, Doreen Badheka, Vincenzo Carnevale, Tibor Rohacs   +6 more
openaire   +2 more sources

Evolution of vertebrate transient receptor potential vanilloid 3 channels: opposite temperature sensitivity between mammals and western clawed frogs. [PDF]

PLoS Genetics, 2011
Transient Receptor Potential (TRP) channels serve as temperature receptors in a wide variety of animals and must have played crucial roles in thermal adaptation.
Shigeru Saito, Naomi Fukuta, Ryuzo Shingai, Makoto Tominaga   +3 more
doaj   +1 more source

Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle

The Journal of Physiology, Volume 604, Issue 9, Page 3611-3632, 1 May 2026.
Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm, Neha Gupta, Alexandru Mircea, Caoimhin S. Griffin   +3 more
wiley   +1 more source

Roles of TRPV₁ and neuropeptidergic receptors in dorsal root reflex-mediated neurogenic inflammation induced by intradermal injection of capsaicin

Molecular Pain, 2007
Background Acute cutaneous neurogenic inflammation initiated by activation of transient receptor potential vanilloid-1 (TRPV1) receptors following intradermal injection of capsaicin is mediated mainly by dorsal root reflexes (DRRs).
Zou Xiaoju, Xu Xijin, Li Dingge, Lin Qing, Fang Li   +4 more
doaj   +1 more source

Phagocytosis depends on TRPV2-mediated calcium influx and requires TRPV2 in lipids rafts: alteration in macrophages from patients with cystic fibrosis. [PDF]

, 2018
Whereas many phagocytosis steps involve ionic fluxes, the underlying ion channels remain poorly defined. As reported in mice, the calcium conducting TRPV2 channel impacts the phagocytic process.
A Abu-Arish, A Aderem, A Di, A Magenau, A Oláh, A Perez, A Perálvarez-Marín, B Svobodova, D Wang, DJ Hackam, E Hisanaga, E Pernet, F Antigny, F Antigny, G Santoni, H Balghi, H Grassmé, H Matsui, JD Young, JH Guo, Jvan Grevenynghe, K Abe, K Aoyagi, K Simonin-Le Jeune, K-Y Jih, L Ambrus, L Nie, L Petrocellis De, L Wei, LM Carrithers, LV Deriy, M Lévêque, M Nabissi, M Nagasawa, M Nagasawa, M Saito, MD Carrithers, MJ Caterina, MP Kowalski, N Qin, NE Alexis, P Schatzlmaier, P Zhang, T Hishikawa, T Ma, TM Link, Y Iwata, É Sághy   +47 more
core   +4 more sources

UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Migraine

Brain and Behavior, Volume 16, Issue 4, April 2026.
This case series followed patients receiving medicinal cannabis for migraine headache for up to 2 years. At 24 months, there were significant improvements in measures assessing headache impact, anxiety, sleep quality, and general quality of life. Note that 15.27% of patients reported an adverse event, most of which were mild or moderate in severity ...
Lennon Hooper, Simon Erridge, Evonne Clarke, Katy McLachlan, Ross Coomber, Augustin Iqbal, James J. Rucker, Mark W. Weatherall, Mikael H. Sodergren   +8 more
wiley   +1 more source

What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel? [PDF]

, 2013
Transient receptor potential (TRP) ion channels are emerging as a new set of membrane proteins involved in a vast array of cellular processes and regulated by a large number of physical and chemical stimuli, which involves them with sensory cell ...
Doñate-Macian, Pau, Gaudet, Rachelle, Perálvarez-Marín, Alex   +2 more
core   +1 more source

Antinociceptive Effect of Cinnamaldehyde in Male Mice: Investigation of the Mechanisms of Action Through In Silico and In Vivo Approaches

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT Cinnamaldehyde (CA), a major component of Cinnamomum spp. essential oils, has recognized bioactivity, including possible analgesic effects. However, its acute antinociceptive mechanisms remain unclear. This study assessed the influence of CA (15, 30, and 60 mg/kg, p.o.) on locomotor and exploratory behaviors via rotarod and open field tests in
Renaly I. de A. Rêgo, Hugo F. O. Pires, Arthur L. Dias, Maria Caroline R. B. Remigio, Humberto H. N. de Andrade, Pablo R. da Silva, Natália F. de Sousa, Luciana Scotti, Marcus T. Scotti, Mirian G. S. S. Salvadori, Ricardo D. de Castro   +10 more
wiley   +1 more source

Temperature Dependence of Mutant Vanilloid Receptor (tRPV) Channels [PDF]

Biophysical Journal, 2011
Temperature-gated transient receptor potential (TRP) channels exhibit exceedingly large energetic changes in activation. However, the source of energy and its structural basis are not known. Several studies have recently suggested that the pore domain of the channels plays an essential role in temperature gating.
Yao, Jing, Liu, Beiying, Qin, Feng
openaire   +1 more source

TRPV4—A Multifunctional Cellular Sensor Protein with Therapeutic Potential

Sensors
Transient receptor potential vanilloid (TRPV) channel proteins belong to the superfamily of TRP proteins that form cationic channels in the animal cell membranes.
Sanna Koskimäki, Sari Tojkander
doaj   +1 more source