Results 101 to 110 of about 15,128 (217)

Inhibition of Microglial TRPV1 Ameliorates Brain Injury After Intracerebral Hemorrhage by Suppressing AMPK/PINK1‐Mediated Mitophagy

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
After intracerebral hemorrhage, microglial TRPV1 channel opening increases intracellular calcium, triggering excessive AMPK‐PINK1‐mediated mitophagy. This causes microglial dysfunction, neuronal necrosis/apoptosis, blood–brain barrier disruption, and neurological impairment.
Kezhu Chen, Xiangyang Deng, Jun Zeng, Baoye Sun, Jingyu Yu, Tianwen Li, Junjie Zhong, Pengjie Hong, Peng Wang, Fengshi Li, Quan Zhang, Junwei Ren, Qisheng Tang, Tongming Zhu, Jianhong Zhu   +14 more
wiley   +1 more source

Co-administration of cannabidiol and capsazepine reduces L-DOPA-induced dyskinesia in mice: Possible mechanism of action

Neurobiology of Disease, 2016
Pharmacological manipulation of the endocannabinoid system represents a promising therapy to alleviate L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) in Parkinson's disease (PD).
Maurício dos-Santos-Pereira, Célia Aparecida da-Silva, Francisco Silveira Guimarães, Elaine Del-Bel   +3 more
doaj   +1 more source

The Thoracic Lymphatic Vasculature: Interorgan Strategies to Achieve an Optimal Tissue Function

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
In the thorax, organ‐specific features such as stomata and submesothelial lacunae, pulmonary perivascular and peribronchial vessels, and subepicardial lymphatic network allow the thoracic lymphatics to perform as a dynamically regulated system able to exploit local mechanical forces and tissue‐specific architecture to maintain fluid and solute ...
Daniela Negrini, Eleonora Solari, Cristiana Marcozzi, Andrea Moriondo   +3 more
wiley   +1 more source

The ethanol extract of cocoa pod husk minimizes hyperalgesia and blood glucose levels in diabetic neuropathy model through transient receptor protein vanilloid (TRPV)-1

Saudi Pharmaceutical Journal
Oxidative stress accumulation becomes a pathophysiological factor in diabetic neuropathy (DN), activating TRPV-1. Resveratrol in cocoa pod husk exhibits antioxidant activity that could be beneficial in DN.
Fifteen Aprila Fajrin, Diana Holidah, Heni Nurhidayah, Putri Suci Wulansari, Didik Pudji Restanto, Lailatul Azkiyah, Yuli Witono, Ari Satia Nugraha   +7 more
doaj   +1 more source

Transient Receptor Potential Cation Channel Subfamily Vanilloid 4 and 3 in the Inner Ear Protect Hearing in Mice

Frontiers in Molecular Neuroscience, 2019
The transient receptor potential cation channel, vanilloid type (TRPV) 3, is a member of the TRPV subfamily that is expressed predominantly in the skin, hair follicles, and gastrointestinal tract. It is also distributed in the organ of Corti of the inner
Shengnan Wang, Shengnan Wang, Shengnan Wang, Shengnan Wang, Qiaowei Geng, Qiaowei Geng, Qiaowei Geng, Qiaowei Geng, Lifang Huo, Lifang Huo, Lifang Huo, Yirui Ma, Yirui Ma, Yirui Ma, Yirui Ma, Yiting Gao, Yiting Gao, Yiting Gao, Yiting Gao, Wei Zhang, Wei Zhang, Wei Zhang, Hailin Zhang, Hailin Zhang, Hailin Zhang, Hailin Zhang, Ping Lv, Ping Lv, Ping Lv, Ping Lv, Zhanfeng Jia, Zhanfeng Jia, Zhanfeng Jia, Zhanfeng Jia   +33 more
doaj   +1 more source

The Mitochondrial Ca(2+) Uniporter: Structure, Function, and Pharmacology. [PDF]

, 2017
Mitochondrial Ca(2+) uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca(2+) uptake and our current understanding of mitochondrial Ca(2+)
A Quintana, A Raffaello, A Rasola, A Tosatto, A Varadi, AA Rowland, AI Tarasov, AN Antony, AR Marks, B Chance, B Glancy, B Moreau, C Giorgi, C Petrungaro, CC Mendes, CD Lobaton, CV Logan, CV Nicchitta, D Chaudhuri, D Chaudhuri, D De Stefani, D Jiang, D Lewis-Smith, D Tomar, D Vecellio Reane, DA Cox, DD Hall, DG Nicholls, DJ Pagliarini, E Carafoli, E Carafoli, E Kovacs-Bogdan, E Murphy, E Noack, E Rapizzi, F Fieni, F Fieni, F Perocchi, FD Vasington, G Bathori, G Beutner, G Beutner, G Csordas, G Csordas, G Csordas, G Csordas, G Csordas, G Csordas, G Csordas, G Czirjak, G Giannini, G Hajnoczky, G Hajnoczky, G Huang, G Michels, G Munch, G Szabadkai, G Szalai, G Szanda, G Szanda, GA Rutter, GC Sparagna, GD Schellenberg, GL Becker, H Vais, HF Deluca, I Bogeski, I Drago, I Zimanyi, J Matesanz-Isabel, J Nakai, J O-Uchi, J O-Uchi, J O-Uchi, J Qiu, J Santo-Domingo, J Schwartz, JD Martell, JG McCormack, JL Harrington, JM Baughman, JQ Kwong, JS Marchant, JT Lanner, JW Putney Jr, K Mallilankaraman, K Mallilankaraman, K Oxenoid, KJ Kamer, KM Holmstrom, L Buntinas, L Hymel, L Mela, L Wang, LH Jeyakumar, LK Seidlmayer, LS Jouaville, M Boerries, M Crompton, M Crompton, M Giacomello, M Giacomello, M Hoth, M Hoth, M Montero, M Montero, M Murgia, M Patron, M Plovanich, M Salvi, M Sastrasinh, MA Matlib, MF Tsai, MK Park, ML Joiner, ML Joiner, ML Litsky, ML Olson, MR Alam, MR Duchen, N MacQuaide, NE Hoffman, NJ Dolman, P Bernardi, P Koncz, P Pinton, PJ Doonan, PS Brookes, R Amann, R Jakob, R Malli, R Malli, R Perez-Campo, R Rizzuto, R Rizzuto, R Rizzuto, R Rizzuto, RM Denton, RM Denton, RM Denton, RS Sohal, S Feng, S Fuente de la, S Grimm, S Marchi, S Shanmughapriya, S Xu, SA Thayer, SS Lam, SY Ryu, T Pozzan, T Rharass, T Yamamoto, TE Gunter, TE Gunter, TE Gunter, TS Luongo, V Hung, V Paupe, VK Sharma, W Tan, WL Ying, X Pan, X Quan, Y Kirichok, Y Lee, Y Sancak, Y Wu   +167 more
core   +2 more sources

Bidirectional Roles of TRPV1 in a Latent Sensitization Model of Myofascial Low Back Pain

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Introduction Chronic primary low back pain (cpLBP) is a global health concern with poorly understood pathomechanisms, potentially involving spinal sensitization. The capsaicin receptor TRPV1 plays a crucial role in sensitization across pain models.
Vivian Blechschmidt, Bastian Schlickenrieder, Jonathan R. Husk, Ulrich Hoheisel, Handan Mörz, Rolf‐Detlef Treede, Wolfgang Greffrath   +6 more
wiley   +1 more source

Influence of 1α, 25-dihydroxyvitamin D3 [1, 25(OH)2D3] on the expression of Sox 9 and the transient receptor potential vanilloid 5/6 ion channels in equine articular chondrocytes [PDF]

, 2014
Background Sox 9 is a major marker of chondrocyte differentiation. When chondrocytes are cultured in vitro they progressively de-differentiate and this is associated with a decline in Sox 9 expression. The active form of vitamin D, 1, 25 (OH)2D3 has
B Lehmann, B Nilius, BD Boyan, CJ Brew, D Kumar, DK Bonen, E Wright, EC Castillo, G Hargus, GS Lee, H Akiyama, HM Embark, I Kou, I Sekiya, IM Hdud, IM Hdud, IM Hdud, J Teerapornpuntakit, JC Fleet, JG Hoenderop, JG Hoenderop, JI Sive, K Gavenis, LC Bridgewater, LC Tetlow, LP Zanello, M Cucchiarini, M Fernandez-Cancio, M Zhang, MR Haussler, N Shintani, PD Benya, PM Gebhard, Q Zhao, R Bouillon, R Vennekens, RJ Wood, S Morais Da Silva, S Taparia, SJ Van Cromphaut, SR Tew, SR Tew, T Aigner, T Kirsch, T Nijenhuis, T Wagner, V Lefebvre, W Bi, W Bi, WF Xie, Y Kawakami, Y Koyano, Y Song, Y Xue   +53 more
core   +2 more sources

Structural Insights into TRPV Channel Gating

The FASEB Journal, 2020
The transient receptor potential vanilloid 5 (TRPV5) channel is a highly calcium selective ion channel that regulates systemic calcium homeostasis by acting as a critical gate for calcium reabsorption in the kidney. Human polymorphisms of this channel have exemplified the importance of TRPV5 in disorders of calcium homeostasis, but atomic level ...
openaire   +1 more source

TRPV4: Molecular Conductor of a Diverse Orchestra [PDF]

, 2016
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective cation channel, originally described in 2000 by research teams led by Schultz ( Nat Cell Biol 2: 695 –702, 2000) and Liedtke ( Cell 103: 525–535, 2000).
Cibelli, Mario, McGeown, J. Graham, Nagy, Istvan, Nilius, Bernd, Urban, Laszlo, White, John P M   +5 more
core   +1 more source