Results 191 to 200 of about 27,030 (231)

Optical Control of TRPV1 Channels

Angewandte Chemie - International Edition, 2013
Dirk Trauner, Marco Stein
exaly   +3 more sources

TRPV1 in Pain and Itch

2021
Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel that is intensively expressed in the peripheral nerve system and involved in a variety of physiological and pathophysiological processes in mammals. Its activity is of great significance in transmitting pain or itch signals from peripheral sensory neurons to the ...
Fengxian, Li, Fang, Wang
openaire   +2 more sources

TRPV1 in migraine pathophysiology

Trends in Molecular Medicine, 2010
Migraine is among the most prevalent headache disorders and results from dysfunctions within the trigeminovascular system (TVS). The inflammatory processes that have been suggested to occur in the cascade of events resulting in migraine sensitise trigeminal nociceptors, possibly causing hyperalgesia and allodynia.
Jannis E, Meents, Lars, Neeb, Uwe, Reuter   +2 more
openaire   +2 more sources

TRPV1 and Synaptic Transmission

Current Pharmaceutical Biotechnology, 2011
Transient Receptor Potential Vanilloid Type 1 is a prominent "pain" receptor expressed in sensory afferent neurons. TRPV1 on peripheral nerve terminals detects a variety of noxious stimuli generated at sites of injury and inflammation, and in turn, drives the excitation and sensitization of C-fibers neurons.
Jose A, Matta, Gerard P, Ahern
openaire   +2 more sources

Structure and function of TRPV1

Pflügers Archiv - European Journal of Physiology, 2005
Capsaicin, the main ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The capsaicin receptor, transient receptor potential vanilloid 1 (TRPV1), is predicted to have six transmembrane (TM) domains and a short, pore ...
Makoto, Tominaga, Tomoko, Tominaga
openaire   +2 more sources

Regulation of TRPV1 by a novel renally expressed rat TRPV1 splice variant

American Journal of Physiology-Renal Physiology, 2006
The capsaicin receptor and transient receptor potential channel TRPV1 senses heat, protons, and vanilloid agonists in peripheral sensory ganglia. Abundant data have suggested the presence of potentially novel splice variants in the kidney. We report a novel rat TRPV1 splice variant, TRPV1VAR, cloned from kidney papilla. TRPV1VAR cDNA was identified in
Wei, Tian, Yi, Fu, Donna H, Wang, David M, Cohen   +3 more
openaire   +2 more sources

Assay of TRPV1 Receptor Signaling

2016
The transient receptor potential vanilloid-1 ion channel (TRPV1) is a non-selective ligand-gated cation channel. It is an integrator of a wide variety of exogenous and endogenous physical and chemical stimuli, including capsaicin, noxious heat (>42 °C), and protons (pH 
Schiano Moriello Aniello, De Petrocellis Luciano   +1 more
openaire   +3 more sources

TRPV1 Antagonists

2012
GOMTSYAN ARTHUR, DAANEN JEROME F, GFESSER GREGORY A, KORT MICHAEL E, LEE CHIH-HUNG, MCDONALD HEATH A, PUTTFARCKEN PAMELA S, VOIGHT ERIC A, KYM PHILIP R   +8 more
  +7 more sources

TRPV1 ANTAGONISTS

2013
WOLLER KEVIN R, GFESSER GREGORY A, LIU HUAQING, DAANEN JEROME F, VOIGHT ERIC A, DRIZIN IRENE I, SHRESTHA ANURUPA, MORTELL KATHLEEN H, KYM PHILIP R, KORT MICHAEL E, GOMTSYAN ARTHUR   +10 more
  +12 more sources

Structural snapshots of TRPV1 reveal mechanism of polymodal functionality

Cell, 2021
Yifan Cheng, David Julius, Kaihua Zhang   +2 more
exaly