Results 171 to 180 of about 26,834 (239)

Ca2+‐Activated Cl− Channels: Do Bestrophins and TMEM16A Interact?

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Ca2+‐activated Cl– conductances are present in many cell types and are important for regulating membrane potential as well as other cellular functions. TMEM16A is widely accepted as the principal molecular basis for Ca2+‐activated Cl– conductances, but also members of the bestrophin family may be important for some Ca2+‐activated Cl ...
Christian Aalkjær, Vibeke Secher Dam, Holger Nilsson, Donna B. Boedtkjer, Vladimir Matchkov   +4 more
wiley   +1 more source

The Novel TRPV1 Agonist ST-6631 Improves Swallowing Function in Rat Models of Stroke-Related Dysphagia and Demonstrates Pharmaceutical Advantage Over Capsaicin, by Exhibiting Minimal Pungent and Irritant Properties. [PDF]

Pharmacol Res Perspect
Miyauchi M, Kitano H, Kochi M, Natsutani I, Mizukami Y, Maezawa Y, Yoshida K, Iwagaki N.   +7 more
europepmc   +1 more source

T Cell Dysfunction in the Acidic Tumor Microenvironment

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Solid tumors are characterized by profound metabolic and vascular abnormalities that generate a hostile tumor microenvironment (TME) marked by extracellular acidosis, hypoxia, and nutrient deprivation. While the consequences of these conditions for cancer cell behavior have been extensively studied, their impact on anti‐tumor immune responses ...
F. B. Christiansen, E. S. Novella, A. V. Lindemann, J. F. H. Cordes, S. F. Pedersen   +4 more
wiley   +1 more source

Sensory Neuroimmunology: Bidirectional Neuro-Immune Circuits Governing Pain, Itch, Inflammation, and Host Defense at Barrier Surfaces. [PDF]

Biology (Basel)
Mosaddeghi-Heris R, Forghani N, Safari Dehnavi N, Saberivand M, Tahavvori A, Azin S, Taheri N, Martelletti P.   +7 more
europepmc   +1 more source

Investigation of the active compounds and pharmacological mechanisms of <i>Qufengxuanfei decoction</i> in the treatment of chronic cough. [PDF]

Front Med (Lausanne)
Liu Z, Li J, Ji K, Wen S, Dong S, Wang Y, Luo J, Ma J, Shi L.   +8 more
europepmc   +1 more source

Clinical Study of Narrow‐Band Intense Pulsed Light with Different Parameters in the Treatment of Erythematotelangiectatic rosacea: A Retrospective Study

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Object To explore the clinical efficacy of a narrow‐band intense pulsed light (DPL) with different energy density in the treatment of erythematotelangiectatic rosacea (ETR). Methods A retrospective study was conducted on patients diagnosed with erythema telangiectatic rosacea who received 5 DPL treatment sessions in the laser cosmetology ...
Lingling Yang, Wenzhong Xiang, Yong Zhang   +2 more
wiley   +1 more source

Preferential renal tubular injury and increased renal sympathetic activity occur during the early stages of DOCA‐salt hypertension in male rats

Physiological Reports, Volume 14, Issue 11, June 2026.
Evaluation of cardiovascular parameters and renal mediators during the development of arterial hypertension in male DOCA‐Salt rats. Abstract Although renal dysfunction is present in arterial hypertension, the mechanisms underlying renal glomerular and tubular alterations remain incompletely understood.
Edina Da Luz Abreu, Rafael S. Carvalhal, Ana Caroline Marreiros, Stephanie F. Gerolin, Laura Barroso F. Oliveira, Maria Eduarda Abreu‐Cunha, Diogo B. Peruchetti, Cristiane D. Gil, Cássia T. Bergamaschi, Ruy R. Campos   +9 more
wiley   +1 more source

TRPV1 in Cardiovascular Disease: A Molecular Nexus of Treatment. [PDF]

Biomolecules
Lu Q, Ding X, Gao B.
europepmc   +1 more source

Chan–Lam Cross‐Coupling With Alkylboron Reagents: From Transmetallation to Radical Pathways

European Journal of Organic Chemistry, Volume 29, Issue 18, 14 May 2026.
Alkylative Chan–Lam coupling overcomes intrinsic transmetallation limitations of alkylboron reagents by engaging radical pathways. Recent advances reveal how radical and radical–polar crossover mechanisms enable mild C(sp3)—heteroatom bond formation. This minireview highlights key mechanistic insights and emerging strategies that transform alkylboron ...
Nicolas G.‐Simonian, Andrea Serafino, Luc Neuville, Géraldine Masson   +3 more
wiley   +1 more source

Nociceptor neurons shape antiviral immunity. [PDF]

J Neuroinflammation
Thomas I, Roger A, Rafei M, Gee K, Talbot S, Basta S.   +5 more
europepmc   +1 more source