Results 281 to 290 of about 42,288 (305)

Structure and function of TRPV1

Pflügers Archiv - European Journal of Physiology, 2005
Capsaicin, the main ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The capsaicin receptor, transient receptor potential vanilloid 1 (TRPV1), is predicted to have six transmembrane (TM) domains and a short, pore ...
Makoto, Tominaga, Tomoko, Tominaga
openaire   +2 more sources

The TRPV1 receptor and nociception

Seminars in Cell & Developmental Biology, 2006
The capsaicin receptor TRPV1 is an emerging target for the treatment of pain with a unique expression profile in peripheral nociceptors and the ability to show polymodal activation, TRPV1 is an important integrator of responses to inflammatory mediators. Sensitization of TRPV1 during chronic pain is believed to contribute to the transduction of noxious
David C, Immke, Narender R, Gavva
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Analgesic potential of TRPV1 antagonists

Biochemical Pharmacology, 2009
The discovery of TRPV1 antagonists as a new class of analgesic agents for the treatment of chronic pathological pain has been pursued aggressively across the pharmaceutical industry. This effort has led to the identification of several TRPV1 antagonists that have entered clinical trials, including ABT-102 (Abbott), SB-705498 (GSK), AMG-517 (Amgen ...
Philip R, Kym, Michael E, Kort, Charles W, Hutchins   +2 more
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Monoacylglycerols Activate Capsaicin Receptor, TRPV1

Lipids, 2008
AbstractTransient receptor potential vanilloid subtype 1 (TRPV1) is known as capsaicin (CAP) receptor and activated by CAP. Activation of TRPV1 by CAP increases energy expenditure and thermogenesis in rodents or human. Therefore, TRPV1 may be target for energy expenditure enhancement and thermogenesis.
Yusaku, Iwasaki, Orine, Saito, Manabu, Tanabe, Kimiko, Inayoshi, Kenji, Kobata, Shuichi, Uno, Akihito, Morita, Tatsuo, Watanabe   +7 more
openaire   +2 more sources

Regulation of TRPV1 by a novel renally expressed rat TRPV1 splice variant

American Journal of Physiology-Renal Physiology, 2006
The capsaicin receptor and transient receptor potential channel TRPV1 senses heat, protons, and vanilloid agonists in peripheral sensory ganglia. Abundant data have suggested the presence of potentially novel splice variants in the kidney. We report a novel rat TRPV1 splice variant, TRPV1VAR, cloned from kidney papilla. TRPV1VAR cDNA was identified in
Wei, Tian, Yi, Fu, Donna H, Wang, David M, Cohen   +3 more
openaire   +2 more sources

Assay of TRPV1 Receptor Signaling

2016
The transient receptor potential vanilloid-1 ion channel (TRPV1) is a non-selective ligand-gated cation channel. It is an integrator of a wide variety of exogenous and endogenous physical and chemical stimuli, including capsaicin, noxious heat (>42 °C), and protons (pH 
Schiano Moriello Aniello, De Petrocellis Luciano   +1 more
openaire   +3 more sources

Ligandi TRPV1

2014
The present invention relates to high affinity compounds, able to bind the transient receptor potential cation channel, subfamily Vanilloid, type 1 or TRPV1. Being this receptor involved in pain processing and neurogenic inflammatory 5 responses and being up-regulated during chronic pain conditions, the compounds of the invention find particular ...
Brizzi A, AIELLO, Francesca, Corelli F.
openaire   +1 more source

TRPV1-Targeted Drugs in Development for Human Pain Conditions

Drugs, 2020
M. Iftinca, M. Defaye, C. Altier
semanticscholar   +1 more source

[Capsaicin receptor TRPV1].

Brain and nerve = Shinkei kenkyu no shinpo, 2008
Transient receptor potential vanilloid 1 (TRPV1) is a receptor for capsaicin, which is a main ingredient in hot chili peppers, and belongs to the TRP ion channel superfamily. Researchers have confirmed that TRPV1 is activated by multiple nociceptive stimuli including protons, noxious heat and some lipids both in the heterologous expression system using
openaire   +1 more source

TRPV1

2006
  +4 more sources