Results 161 to 170 of about 4,775 (199)

Astrocytes express functional TRPV2 ion channels

Biochemical and Biophysical Research Communications, 2013
Thermosensitive transient receptor potential (thermo TRP) channels are important for sensory transduction. Among them, TRPV2 has an interesting characteristic of being activated by very high temperature (>52 °C). In addition to the heat sensor function, TRPV2 also acts as a mechanosensor, an osomosensor and a lipid sensor.
Yasuki Ishizaki, Koji Shibasaki
exaly   +3 more sources

TRPV2

2014
Transient receptor potential vanilloid type 2, TRPV2, is a calcium-permeable cation channel belonging to the TRPV channel family. This channel is activated by heat (>52 °C), various ligands, and mechanical stresses. In most of the cells, a large portion of TRPV2 is located in the endoplasmic reticulum under unstimulated conditions.
Itaru, Kojima, Masahiro, Nagasawa
openaire   +2 more sources

TRPV2 expression in rat oral mucosa

Histochemistry and Cell Biology, 2009
The oral mucosa is a highly specialised, stratified epithelium that confers protection from infection and physical, chemical and thermal stimuli. The non-keratinised junctional epithelium surrounds each tooth like a collar and is easily attacked by foreign substances from the oral sulcus.
Daiji, Shimohira, Mizuho A, Kido, Atsushi, Danjo, Tomoka, Takao, Bing, Wang, Jing-Qi, Zhang, Takayoshi, Yamaza, Sadahiko, Masuko, Masaaki, Goto, Teruo, Tanaka   +9 more
openaire   +2 more sources

Blockade of TRPV2 is a Novel Therapy for Cardiomyopathy in Muscular Dystrophy

International Journal of Molecular Sciences, 2019
Muscular dystrophy and dilated cardiomyopathy are intractable diseases and their treatment options are very limited. Transient receptor potential cation channel subfamily V, member 2 (TRPV2), is a stretch-sensitive Ca2+-permeable channel that causes ...
Tsuyoshi Matsumura, Yuko Iwata
exaly   +2 more sources

Formation of a physiological complex between TRPV2 and RGA protein promotes cell surface expression of TRPV2

Journal of Cellular Biochemistry, 2004
AbstractThe transient receptor potential, sub‐family Vanilloid (TRPV)2 cation channel is activated in response to extreme temperature elevations in sensory neurons. However, TRPV2 is widely expressed in tissues with no sensory function, including cells of the immune system.
Alexander J, Stokes, Clay, Wakano, Kimberly A, Del Carmen, Murielle, Koblan-Huberson, Helen, Turner   +4 more
openaire   +2 more sources

TRPV2-immunoreactive intrinsic neurons in the rat intestine

Neuroscience Letters, 2004
Transient receptor potential channel vanilloid subfamily 2 (TRPV2) was shown to receive noxious thermal stimuli (>52 degrees C), and to be expressed in fine myelinated afferent neurons. The mRNA and the immunoreactivity have also been detected in several peripheral tissues. We examined the expression of TRPV2 in the rat intestine.
Hitoshi Kashiba, Daisuke Takeda, Koichi Kuribayashi   +2 more
exaly   +3 more sources

Lysophosphatidylcholine sensitizes TRPV2 by indirect mechanisms

Pflügers Archiv - European Journal of Physiology
The ion channel TRPV2 has multiple roles in immunology, cancer, cardiovascular function and pain signaling. However, only few endogenous modulators of TRPV2 have been described. The phospholipase A2 (PLA2)-derived lipid lysophosphatidylcholine (LPC) was demonstrated to induce pain and itch by activating sensory neurons, and it seems to be a direct ...
Marvin J A, Meyer, George, Oprita, Tabea C, Fricke, Inês, Carvalheira Arnaut Pombei Stein, Frank G, Echtermeyer, Christine, Herzog, Andreas, Leffler   +6 more
openaire   +2 more sources

Structural insights into TRPV2 modulation by probenecid

Nature Structural & Molecular Biology
The transient receptor potential vanilloid 2 (TRPV2) cation channel is a key player in cardiovascular physiology and pathophysiology. Probenecid (PBC), an FDA-approved uricosuric agent thought to activate TRPV2, has shown promise in enhancing cardiovascular function in both preclinical and clinical studies.
Julia A. Rocereta, Toni Sturhahn, Ruth A. Pumroy, Tabea C. Fricke, Christine Herzog, Andreas Leffler, Vera Moiseenkova-Bell   +6 more
openaire   +2 more sources

Regulation of TRPV2 by axotomy in sympathetic, but not sensory neurons

Brain Research, 2004
Neuropathic pain results from traumatic or disease-related insults to the nervous system. Mechanisms that have been postulated to underlie peripheral neuropathy commonly implicate afferent neurons that have been damaged but still project centrally to the spinal cord, and/or intact neurons that interact with degenerating distal portions of the injured ...
Andrew D, Gaudet, Sarah J, Williams, Lucy P-R, Hwi, Matt S, Ramer   +3 more
openaire   +2 more sources

Distribution of CGRP and TRPV2 in Human Paranasal Sinuses

Cells Tissues Organs, 2016
Immunohistochemistry for protein gene product 9.5 (PGP 9.5), calcitonin gene-related peptide (CGRP) and the transient receptor potential cation channel subfamily V member 2 (TRPV2) was performed on human paranasal sinuses. It was found that in the paranasal sinuses, mucous membranes contain PGP 9.5-immunoreactive (PGP 9.5-IR) nerve fibers.
Tadasu, Sato, Nobuyuki, Sasahara, Noriyuki, Kanda, Yu, Sasaki, Yu, Yamaguma, Souichi, Kokubun, Takehiro, Yajima, Hiroyuki, Ichikawa   +7 more
openaire   +2 more sources