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The role of TRPV channels in osteoporosis
Molecular Biology Reports, 2021As the world's population ages, the treatment of osteoporosis is a major problem to be addressed. The cause of osteoporosis remains unclear. Ca2+ is not only an important component of bones but also plays a key role in osteoporosis treatment. Transient receptor potential vanilloid (TRPV) channels are one of the TRP channel families that is widely ...
Na Liu, Weiwei Lu
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The mechanosensitive nature of TRPV channels
Pflugers Archiv European Journal of Physiology, 2005Transient receptor potential vanilloid (TRPV) channels are widely expressed in both sensory and nonsensory cells. Whereas the channels display a broad diversity to activation by chemical and physical stimuli, activation by mechanical stimuli is common to many members of this group in both lower and higher organisms.
Stefan Heller
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Hot flash: TRPV channels in the brain
Trends in Neurosciences, 2009TRPV1 (transient receptor potential, vanilloid) channels belong to a family of ligand-gated ion channels gated not only by the binding of certain lipophilic molecules but also by extracellular protons and physical stimuli such as heat or osmotic pressure changes. These nonselective cation channels are permeable to Na(+) and K(+) and are also very Ca(2+)
Julie A, Kauer, Helen E, Gibson
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TRPV Channels in Tumor Growth and Progression
2010Transient receptor potential (TRP) channels affect several physiological and pathological processes. In particular, TRP channels have been recently involved in the triggering of enhanced proliferation, aberrant differentiation, and resistance to apoptotic cell death leading to the uncontrolled tumor invasion.
SANTONI, Giorgio +2 more
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TRPV channels as thermosensory receptors in epithelial cells
Pflugers Archiv European Journal of Physiology, 2005Temperature-sensitive transient receptor potential vanilloid (TRPV) ion channels are critical contributors to normal pain and temperature sensation and therefore represent attractive targets for pain therapy. When these channels were first discovered, most attention was focused on their potential contributions to direct thermal activation of peripheral
Hyosang, Lee, Michael J, Caterina
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The diversity in the vanilloid (TRPV) receptor family of ion channels
Trends in Pharmacological Sciences, 2002Following cloning of the vanilloid receptor 1 (VR1) at least four other related proteins have been identified. Together, these form a distinct subgroup of the transient receptor potential (TRP) family of ion channels. Members of the vanilloid receptor family (TRPV) are activated by a diverse range of stimuli, including heat, protons, lipids, phorbols ...
Andrew Randall
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Functional TRPV and TRPM channels in human preadipocytes
Pflügers Archiv - European Journal of Physiology, 2013Preadipocytes are widely used as an in vitro model to investigate proliferation, adipogenic differentiation, and lipodystrophy; however, cellular physiology and biology are not fully understood in human preadipocytes. The present study was to investigate the expression of transient receptor potential (TRP) channels in human preadipocytes and their ...
Tse, HF, CHE, H, Yue, J, Li, GR
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2013
From a pharmacological point of view, the transient receptor potential (TRPV) family of ion channels are interesting drug targets. After the identification of the TRPV1 channel, an attractive candidate for analgesic intervention, many agonists and antagonists were generated.
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From a pharmacological point of view, the transient receptor potential (TRPV) family of ion channels are interesting drug targets. After the identification of the TRPV1 channel, an attractive candidate for analgesic intervention, many agonists and antagonists were generated.
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TRPV Channels’ Role in Osmotransduction and Mechanotransduction
2007In signal transduction of metazoan cells, transient receptor potential (TRP) ion channels have been identified that respond to diverse external and internal stimuli, among them osmotic and mechanical stimuli. This chapter will summarize findings on the TRPV subfamily, both its vertebrate and invertebrate members.
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A TRPV family ion channel required for hearing in Drosophila
Nature, 2003The many types of insect ear share a common sensory element, the chordotonal organ, in which sound-induced antennal or tympanal vibrations are transmitted to ciliated sensory neurons and transduced to receptor potentials. However, the molecular identity of the transducing ion channels in chordotonal neurons, or in any auditory system, is still unknown.
Janghwan, Kim +11 more
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