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Fevers, TRPV channels, and birth defects
Science, 2017Reproductive Biology Cardiac and craniofacial birth defects are common, but many cannot be attributed to specific mutations. An environmental trigger associated with these birth defects is maternal fever during the first trimester. Using chick and zebrafish embryos, Hutson et al.
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Link Between TRPV Channels and Mast Cell Function
2007Mast cells are tissue-resident immune effector cells. They respond to diverse stimuli by releasing potent biological mediators into the surrounding tissue, and initiating inflammatory responses that promote wound healing and infection clearance. In addition to stimulation via immunological routes, mast cells also respond to polybasic secretagogues and ...
H, Turner, K A, del Carmen, A, Stokes
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Perspectives on TRPV Channels in the Structural and Computational Revolution Era
Transient Receptor Potential Vanilloid (TRPV) channels are a subfamily of six membrane proteins involved in various physiological processes. TRPVs share a pore channel between the fifth and sixth domains, which can be activated or inactivated by temperature, pain, and cellular homeostasis.Eric, Catalina-Hernandez +2 more
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Closing in on the heat‐activation mechanisms of TRPV channels
The Journal of Physiology, 2021openaire +2 more sources
Ruthenium red: Blocker or antagonist of TRPV channels?
Cell CalciumRuthenium red (RR) is a widely used inhibitor of Transient Receptor Potential (TRP) cation channels and other types of ion channels. Although RR has been generally accepted to inhibit TRP channels by physically blocking the ion permeation pathway, recent structural evidence suggests that it might also function as an antagonist, inducing conformational ...
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TRPV channels as insecticide targets
2016 International Congress of Entomology, 2016openaire +1 more source