Results 141 to 150 of about 3,404 (180)

Cytological profiling of trypanocidal principles from <i>Aloe barbadensis</i> and <i>Taraxacum officinale</i>. [PDF]

Phytomed Plus
Akazue PI, Quashie NB, Osei-Safo D, Vaughan S, de Koning HP, Gwira TM.   +5 more
europepmc   +1 more source

Antitrypanosomal potential of Salvia officinalis terpenoids-rich fraction in Trypanosoma evansi-infected rat model. [PDF]

BMC Vet Res
Sawerus MG, Kamel HH, Ahmed WMS, Ata EB, El Amir D, Mahdi EA, Ibrahim MA, Shehata O.   +7 more
europepmc   +1 more source

Interventions for Neglected Diseases Caused by Kinetoplastid Parasites: A One Health Approach to Drug Discovery, Development, and Deployment. [PDF]

Pharmaceuticals (Basel)
Ebiloma GU, Alhejeli A, de Koning HP.
europepmc   +1 more source

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Methylating agents as trypanocides

Journal of Medicinal Chemistry, 1990
Methylating agents, such as streptozotocin, procarbazine, N-methyl-N-nitrosourea, dimethyl sulfate, 1,2-dimethylhydrazine, and a series of 1,2-bis(sulfonyl)-1-methylhydrazines synthesized in this laboratory, were evaluated and shown to be therapeutically active against murine models of African trypanosomiasis.
P G, Penketh, K, Shyam, A A, Divo, C L, Patton, A C, Sartorelli   +4 more
openaire   +2 more sources

Synthesis of sydnonimine derivatives as potential trypanocidal agents

Journal of Heterocyclic Chemistry, 2003
AbstractN‐(p‐Nitrophenoxy)carbonyl‐3‐morpholino‐sydnonimine (NCMS) has been prepared from 3‐morpholinosydnonimine hydrochloride. Using the Griess assay and the superoxide‐mediated reduction of ferricytochrome c, the nitric oxide (NO•) and superoxide anion (O2•‐) ‐ releasing properties in phosphate buffer pH 7.4 of this novel peroxynitrite donor was ...
Laurent Soulere, Frederic Bringaud, Pascal Hoffmann   +2 more
openaire   +1 more source

Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents

Bioorganic & Medicinal Chemistry Letters, 2006
The effect of several alkyl-linked bis tetrahydro-(2H)-1,3,5-thiadiazine-2-thione (bis-THTT) on Leishmania donovani, Trypanosoma brucei rhodesiense, and Plasmodium falciparum is reported. Most of the compounds exhibited a potent activity against the three parasitic strains but the best in vitro activity profiles were found against T. b.
Julieta, Coro, Richard, Atherton, Susan, Little, Hayley, Wharton, Vanessa, Yardley, Amaury, Alvarez, Margarita, Súarez, Rolando, Pérez, Hortensia, Rodríguez   +8 more
openaire   +2 more sources

Synthesis and evaluation of 1,2,2-tris(sulfonyl)hydrazines as antineoplastic and trypanocidal agents

Journal of Medicinal Chemistry, 1990
Several 1,2,2-tris(sulfonyl)hydrazines, conceived as prodrugs of 1,2-bis(sulfonyl)hydrazines, were synthesized and evaluated for antineoplastic and trypanocidal activities in mice. 1-Methyl-1,2,2-tris(methylsulfonyl)hydrazine emerged as an extremely efficacious antitrypanosomal agent, whereas 1-(2-chloroethyl)-1,2,2-tris(methylsulfonyl)hydrazine was ...
K, Shyam, P G, Penketh, A A, Divo, R H, Loomis, C L, Patton, A C, Sartorelli   +5 more
openaire   +2 more sources

Photosensitization by the trypanocidal agent crystal violet. Type i versus type II reactions

Chemico-Biological Interactions, 1986
The photoreduction of crystal violet to a carbon-centered radical was detected directly by electron spin resonance (ESR) spectroscopy under anaerobic conditions. The linewidth (0.9 G) of this radical was less broad than the linewidth (11.0 G) of the free radical obtained in Trypanosoma cruzi incubations.
K, Reszka, F S, Cruz, R, Docampo
openaire   +2 more sources

Novel prenyloxy chalcones as potential leishmanicidal and trypanocidal agents: Design, synthesis and evaluation

European Journal of Medicinal Chemistry, 2019
The available drugs for treating Leishmaniasis and American trypanosomiasis have high toxicity and multiple side effects, among other problems. More effective and less toxic treatments are urgently needed. A series of chalcones that contained a prenyloxy or geranyloxy substituent was synthesized and characterized. Each substituent was attached to the A
José C. Espinoza-Hicks, Karla Fabiola Chacón-Vargas, Jessica L. Hernández-Rivera, Benjamín Nogueda-Torres, Joaquín Tamariz, Luvia Enid Sánchez-Torres, Alejandro Camacho-Dávila   +6 more
openaire   +2 more sources

ChemInform Abstract: Synthesis of New Isoxazolylnaphthoquinones as Potential Trypanocidal and Antibacterial Agents.

ChemInform, 1999
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Gladys E. Granero, Maria M. de Bertorello, Margarita C. Brinon   +2 more
openaire   +1 more source