Glycosomal Phosphoenolpyruvate Carboxykinase CRISPR/Cas9-Deletion and Its Role in Trypanosoma cruzi Metacyclogenesis and Infectivity in Mammalian Host. [PDF]
FASEB JEffects of PEPCK deficiency in Trypanosoma cruzi bioenergetics and life stages. ABSTRACT Trypanosoma cruzi, the causative agent of Chagas disease, possesses glycosomes—unique organelles that house key metabolic enzymes, several of which are promising therapeutic targets.
Vieira CSD +8 more
europepmc +2 more sources
Molecular epidemiology of African sleeping sickness [PDF]
, 2009 Human sleeping sickness in Africa, caused by Trypanosoma brucei spp. raises a number of questions. Despite the widespread distribution of the tsetse vectors and animal trypanosomiasis, human disease is only found in discrete foci which periodically give ...
A. TAIT +5 more
core +2 more sources
Veterinary World, 2013 Aim: The objective of present study was to determine Plasma Protein Binding (PPB) activity and its effect on clinical efficacy of isometamidium after intramuscular administration in calves.
Suprita Sinha +2 more
doaj +1 more source
A preliminary serological study of Trypanosoma evansi and Trypanosoma lewisi in a Chinese human population [PDF]
, 2018 Trypanosoma evansi, known as an animal trypanosome, is widely distributed in many countries of Africa, Asia and South America; it causes significant economic loss in these countries.
Courtois, Patrick +8 more
core +1 more source
TcI isolates of Trypanosoma cruzi exploit the antioxidant network for enhanced intracellular survival in macrophages and virulence in mice [PDF]
, 2016 Trypanosoma cruzi species is categorized into six discrete typing units (TcI to TcVI) of which TcI is most abundantly noted in the sylvatic transmission cycle and considered the major cause of human disease. In our study, the TcI strains Colombiana (COL),
Basombrío, Miguel Ángel Manuel +8 more
core +2 more sources
Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei'
eLife, 2022 We thank Keith Matthews and Stephen Larcombe for their thoughtful comment, which follows the good tradition of public scientific discourse (Matthews and Larcombe, 2022).
Jaime Lisack +2 more
doaj +1 more source
Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]
, 2014 It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
A. Schnaufer +32 more
core +1 more source
Protozoan diseases – a marginalized threat of modern civilization
Journal of Education, Health and Sport, 2018 Globalization and the intensification of tourism in tropical and subtropical areas as well as journeys within the framework of military missions often cause the spread and persistence of infectious and parasitic diseases in areas where they previously ...
Marta Sarnowska +5 more
doaj +1 more source
A CRISPR Cas9 high-throughput genome editing toolkit for kinetoplastids [PDF]
Royal Society Open Science, 2017 Clustered regularly interspaced short palindromic repeats (CRISPR), CRISPR-associated gene 9 (Cas9) genome editing is set to revolutionize genetic manipulation of pathogens, including kinetoplastids.
Tom Beneke +5 more
doaj +1 more source
The developmental cell biology of Trypanosoma brucei [PDF]
, 2005 Trypanosoma brucei provides an excellent system for studies of many aspects of cell biology, including cell structure and morphology, organelle positioning, cell division and protein trafficking. However, the trypanosome has a complex life cycle in which
Matthews, Keith R
core +2 more sources