Results 31 to 40 of about 51,869 (195)

Unexpected plasticity in the life cycle of Trypanosoma brucei

eLife, 2021
African trypanosomes cause sleeping sickness in humans and nagana in cattle. These unicellular parasites are transmitted by the bloodsucking tsetse fly. In the mammalian host’s circulation, proliferating slender stage cells differentiate into cell cycle ...
Sarah Schuster, Jaime Lisack, Ines Subota, Henriette Zimmermann, Christian Reuter, Tobias Mueller, Brooke Morriswood, Markus Engstler   +7 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Sensibilité aux trypanocides et au plasma humain de souches de Trypanozoon isolées d’animaux provenant de foyers endémiques de maladie du sommeil au Nigeria

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1995
La sensibilité de douze souches de Trypanozoon isolées de bovins semi-nomades provenant de foyers endémiques connus de maladie du sommeil situés dans le Centre et au Nord du Nigeria a été étudiée vis-à-vis de deux trypanocides, l'acéturate de diminazène (
A.I. Kalu
doaj   +1 more source

Neuropathogenesis caused by Trypanosoma brucei, still an enigma to be unveiled

Microbial Cell, 2021
Trypanosoma brucei is one of the protozoa parasites that can enter the brain and cause injury associated with toxic effects of parasite-derived molecules or with immune responses against infection.
Katherine Figarella
doaj   +1 more source

Frequency and diversity of trypanosomes in sheep and goats from Mongo County in South Gabon, Central Africa [PDF]

Veterinary World, 2020
Background and Aim: Trypanosomosis is a major impediment to livestock farming in sub-Saharan Africa. It is a vector-borne disease caused by several species of protozoan parasites, namely, trypanosomes. The present study aimed to identify the diversity of
Gael Darren Maganga, Larson Boundenga, Emmanuella Jacqueline Ologui-Minkue-Edzo, Linda Bohou Kombila, Telstar Ghestin Ndong Mebaley, Brice Kumulungui, Jacques François Mavoungou   +6 more
doaj   +1 more source

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva, Caio Patrício de Souza Sena, Davi Serradella Vieira, Magdi E. A. Zaki, Leow Chiuan Yee, Shahina Akter, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, João Firmino Rodrigues‐Neto   +8 more
wiley   +1 more source

Protein Profiles of Trypanosoma cruzi and Trypanosoma rangeli [PDF]

Parasitología latinoamericana, 2004
Trypanosoma cruzi, is a protozoan parasite, which has a close phylogenetic relationship with Trypanosoma rangeli that is not pathogenic for the vertebrate host. Both parasites have antigenic similarity, they have different and complex total protein profiles according to their morphological and physiological stage epimastigotes or trypomastigotes ...
MEJÍA, ASTRID J, PALÁU, MARÍA TERESA, ZÚÑIGA, CLAUDIO A   +2 more
openaire   +2 more sources

Post‐LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor

Cytoskeleton, EarlyView.
ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
Stephen M. King
wiley   +1 more source

Trypanosoma evansi as a Major Cause of Animal Trypanosomiasis: A Comprehensive Review

Jurnal Medik Veteriner
Trypanosomiasis caused by Trypanosoma evansi is a major protozoan illness that affects animals worldwide. It is also referred to as “surra” and affects a variety if wild and domestic animals such as sheep, cattle, goats, dogs, buffaloes, pigs, elephants,
Sunaryo Hadi Warsito, Aswin Rafif Khairullah, Mirni Lamid, Mohammad Anam Al-Arif, Herry Agoes Hermadi, Widya Paramita Lokapirnasari, Muhammad Khaliim Jati Kusala, Syahputra Wibowo, Siti Rani Ayuti, Bantari Wisynu Kusuma Wardhani, Ima Fauziah, Sheila Marty Yanestria, Ikechukwu Benjamin Moses, Agung Prasetyo, Suhita Aryaloka, Kartika Afrida Fauzia, Riza Zainuddin Ahmad, Dea Anita Ariani Kurniasih   +17 more
doaj   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source