Results 21 to 30 of about 51,869 (195)

Ubiquitination and the Proteasome as Drug Targets in Trypanosomatid Diseases

Frontiers in Chemistry, 2021
The eukaryotic pathogens Trypanosoma brucei, Trypanosoma cruzi and Leishmania are responsible for debilitating diseases that affect millions of people worldwide.
Marie-José Bijlmakers
doaj   +1 more source

Amélioration de la technique de dissection du tractus digestif et des glandes salivaires des glossines pour la mise en évidence des divers stades de développement des trypanosomes

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1994
Les auteurs décrivent une technique améliorée de dissection de l'intestin moyen et des glandes salivaires des glossines. En ajoutant à la dissection le proventricule, la méthode permet d'obtenir un tableau plus complet du développement des trypanosomes ...
J.M.L. Kazadi, P. Elsen, M. Jochems, J. Van Hees, Jan Van Den Abbeele, P. Kageruka   +5 more
doaj   +1 more source

Trypanosoma

, 2017
Published as part of Ngomtcho, Sen Claudcne Henlcette, Webel, Judcth Sophce, Bum, Elcmabeth Ngo, Gbem, Thaddeum Tellumun, Kelm, SØlge & Achukwc, Mbunkah Dancel, 2017, Molecular screening of tsetse flies and cattle reveal different Trypanosoma species including T. grayi and T. theileri in northern Cameroon, pp. 1-16 in Parasites & Vectors (631) (631) 10
Ngomtcho, Sen Claudcne Henlcette, Webel, Judcth Sophce, Bum, Elcmabeth Ngo, Gbem, Thaddeum Tellumun, Kelm, SØlge, Achukwc, Mbunkah Dancel   +5 more
openaire   +4 more sources

P-type transport ATPases in Leishmania and Trypanosoma

Parasite, 2019
P-type ATPases are critical to the maintenance and regulation of cellular ion homeostasis and membrane lipid asymmetry due to their ability to move ions and phospholipids against a concentration gradient by utilizing the energy of ATP hydrolysis.
Meade John C.
doaj   +1 more source

Highly Localized Enrichment of Trypanosoma brucei Parasites Using Dielectrophoresis

Micromachines, 2020
Human African trypanosomiasis (HAT), also known as sleeping sickness, is a vector-borne neglected tropical disease endemic to rural sub-Saharan Africa.
Devin Keck, Callie Stuart, Josie Duncan, Emily Gullette, Rodrigo Martinez-Duarte   +4 more
doaj   +1 more source

Split-Cre-mediated GFP expression as a permanent marker for flagellar fusion of Trypanosoma brucei in its tsetse fly host

mBio
Trypanosomes have different ways of communicating with each other. While communication via quorum sensing, or by the release and uptake of extracellular vesicles, is widespread in nature, the phenomenon of flagellar fusion has only been observed in ...
Ruth Etzensperger, Mattias Benninger, Berta Pozzi, Ruth Rehmann, Arunasalam Naguleswaran, Gabriela Schumann, Jan Van Den Abbeele, Isabel Roditi   +7 more
doaj   +1 more source

Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3–PEX19 Interaction

Frontiers in Cell and Developmental Biology, 2021
Human pathogenic trypanosomatid parasites harbor a unique form of peroxisomes termed glycosomes that are essential for parasite viability. We and others previously identified and characterized the essential Trypanosoma brucei ortholog TbPEX3, which is ...
Mengqiao Li, Stefan Gaussmann, Stefan Gaussmann, Bettina Tippler, Julia Ott, Grzegorz M Popowicz, Grzegorz M Popowicz, Wolfgang Schliebs, Michael Sattler, Michael Sattler, Ralf Erdmann, Vishal C Kalel   +11 more
doaj   +1 more source

A CRISPR Cas9 high-throughput genome editing toolkit for kinetoplastids [PDF]

Royal Society Open Science, 2017
Clustered regularly interspaced short palindromic repeats (CRISPR), CRISPR-associated gene 9 (Cas9) genome editing is set to revolutionize genetic manipulation of pathogens, including kinetoplastids.
Tom Beneke, Ross Madden, Laura Makin, Jessica Valli, Jack Sunter, Eva Gluenz   +5 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Detection of Trypanosoma spp. in Bandicota indica from the Thai-Myanmar border area, Mae Sot District Tak Province, Thailand

Asian Pacific Journal of Tropical Medicine, 2019
Objective: To investigate the prevalence of trypanosome infection and their phylogeny in Bandicota indica rats from the cadmium-contaminated area of Mae Sot and the Myanmar border.
Phuangphet Waree Molee, Natthiya Sakulsak, Somchai Saengamnatdej   +2 more
doaj   +1 more source