Results 41 to 50 of about 101,216 (253)

Split-Cre-mediated GFP expression as a permanent marker for flagellar fusion of Trypanosoma brucei in its tsetse fly host

mBio
Trypanosomes have different ways of communicating with each other. While communication via quorum sensing, or by the release and uptake of extracellular vesicles, is widespread in nature, the phenomenon of flagellar fusion has only been observed in ...
Ruth Etzensperger, Mattias Benninger, Berta Pozzi, Ruth Rehmann, Arunasalam Naguleswaran, Gabriela Schumann, Jan Van Den Abbeele, Isabel Roditi   +7 more
doaj   +1 more source

Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3–PEX19 Interaction

Frontiers in Cell and Developmental Biology, 2021
Human pathogenic trypanosomatid parasites harbor a unique form of peroxisomes termed glycosomes that are essential for parasite viability. We and others previously identified and characterized the essential Trypanosoma brucei ortholog TbPEX3, which is ...
Mengqiao Li, Stefan Gaussmann, Stefan Gaussmann, Bettina Tippler, Julia Ott, Grzegorz M Popowicz, Grzegorz M Popowicz, Wolfgang Schliebs, Michael Sattler, Michael Sattler, Ralf Erdmann, Vishal C Kalel   +11 more
doaj   +1 more source

Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei. [PDF]

, 2014
Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei ...
Currier, Rachel B., Taane G Clark, Horn, David, José Afonso Guerra-Assunção, Clark, Taane G., Sam Alsford, Taane G. Clark (106263), David Horn (24969), Alsford, Sam, Rachel B Currier, Rachel B. Currier (144838), Guerra-Assunção, José Afonso, Currier, Rachel B, Horn, David; id_orcid, José Afonso Guerra-Assunção (166779), Guerra-Assunção, Jose Alfonso, Sam Alsford (24967), David Horn, Clark, Taane G   +18 more
core   +1 more source

Trypanosoma evansi as a Major Cause of Animal Trypanosomiasis: A Comprehensive Review

Jurnal Medik Veteriner
Trypanosomiasis caused by Trypanosoma evansi is a major protozoan illness that affects animals worldwide. It is also referred to as “surra” and affects a variety if wild and domestic animals such as sheep, cattle, goats, dogs, buffaloes, pigs, elephants,
Sunaryo Hadi Warsito, Aswin Rafif Khairullah, Mirni Lamid, Mohammad Anam Al-Arif, Herry Agoes Hermadi, Widya Paramita Lokapirnasari, Muhammad Khaliim Jati Kusala, Syahputra Wibowo, Siti Rani Ayuti, Bantari Wisynu Kusuma Wardhani, Ima Fauziah, Sheila Marty Yanestria, Ikechukwu Benjamin Moses, Agung Prasetyo, Suhita Aryaloka, Kartika Afrida Fauzia, Riza Zainuddin Ahmad, Dea Anita Ariani Kurniasih   +17 more
doaj   +1 more source

A CRISPR Cas9 high-throughput genome editing toolkit for kinetoplastids [PDF]

Royal Society Open Science, 2017
Clustered regularly interspaced short palindromic repeats (CRISPR), CRISPR-associated gene 9 (Cas9) genome editing is set to revolutionize genetic manipulation of pathogens, including kinetoplastids.
Tom Beneke, Ross Madden, Laura Makin, Jessica Valli, Jack Sunter, Eva Gluenz   +5 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Detection of Trypanosoma spp. in Bandicota indica from the Thai-Myanmar border area, Mae Sot District Tak Province, Thailand

Asian Pacific Journal of Tropical Medicine, 2019
Objective: To investigate the prevalence of trypanosome infection and their phylogeny in Bandicota indica rats from the cadmium-contaminated area of Mae Sot and the Myanmar border.
Phuangphet Waree Molee, Natthiya Sakulsak, Somchai Saengamnatdej   +2 more
doaj   +1 more source

Unexpected plasticity in the life cycle of Trypanosoma brucei

eLife, 2021
African trypanosomes cause sleeping sickness in humans and nagana in cattle. These unicellular parasites are transmitted by the bloodsucking tsetse fly. In the mammalian host’s circulation, proliferating slender stage cells differentiate into cell cycle ...
Sarah Schuster, Jaime Lisack, Ines Subota, Henriette Zimmermann, Christian Reuter, Tobias Mueller, Brooke Morriswood, Markus Engstler   +7 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Sensibilité aux trypanocides et au plasma humain de souches de Trypanozoon isolées d’animaux provenant de foyers endémiques de maladie du sommeil au Nigeria

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1995
La sensibilité de douze souches de Trypanozoon isolées de bovins semi-nomades provenant de foyers endémiques connus de maladie du sommeil situés dans le Centre et au Nord du Nigeria a été étudiée vis-à-vis de deux trypanocides, l'acéturate de diminazène (
A.I. Kalu
doaj   +1 more source