LncRNAs Are Differentially Expressed between Wildtype and Cell Line Strains of African Trypanosomes
Non-Coding RNA, 2022 Trypanosoma brucei is a parasitic protist that causes African sleeping sickness. The establishment of T. brucei cell lines has provided a significant advantage for the majority of T. brucei research. However, these cell lines were isolated and maintained
Hyung Chul Kim, Emmitt R. Jolly
doaj +1 more source
Microorganisms, 2021 Background: In most trypanosomes, endo and exocytosis only occur at a unique organelle called the flagellar pocket (FP) and the flagellum exits the cell via the FP.
Christine E. Broster Reix +10 more
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Broadening the spectrum of ivermectin: Its effect on Trypanosoma cruzi and related trypanosomatids
Frontiers in Cellular and Infection Microbiology, 2022 Chagas disease is an endemic American parasitosis, caused by Trypanosoma cruzi. The current therapies, benznidazole (BZN) and nifurtimox (NFX), show limited efficacy and multiple side effects. Thus, there is a need to develop new trypanocidal strategies.
Laura Fraccaroli +6 more
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Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3–PEX19 Interaction
Frontiers in Cell and Developmental Biology, 2021 Human pathogenic trypanosomatid parasites harbor a unique form of peroxisomes termed glycosomes that are essential for parasite viability. We and others previously identified and characterized the essential Trypanosoma brucei ortholog TbPEX3, which is ...
Mengqiao Li +11 more
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Preliminary Report: Missense mutations in the APOL gene family are associated with end stage kidney disease risk previously attributed to the MYH9 gene [PDF]
Human Genetics, July 16 2010, 2010 MYH9 has been proposed as a major genetic risk locus for a spectrum of non-diabetic end stage kidney disease (ESKD). We use recently released sequences from the 1000 Genomes Project to identify two western African specific missense mutations (S342G and I384M) in the neighbouring APOL1 gene, and demonstrate that these are more strongly associated with ...
arxiv +1 more source
Molecular identification of different trypanosome species and subspecies in tsetse flies of northern Nigeria [PDF]
, 2016 Background: Animal African Trypanosomiasis (AAT) is caused by several species of trypanosomes including Trypanosoma congolense, T. vivax, T. godfreyi, T. simiae and T. brucei. Two of the subspecies of T. brucei also cause Human African Trypanosomiasis.
Ciosi, Marc +8 more
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Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat [PDF]
Nature Microbiology 2 (2017), pp. 1523--1532, 2018 The most prominent defence of the unicellular parasite Trypanosoma brucei against the host immune system is a dense coat that comprises a variant surface glycoprotein (VSG). Despite the importance of the VSG family, no complete structure of a VSG has been reported.
arxiv +1 more source
Protective immunity against Trypanosoma cruzi [PDF]
, 2009 Upon infection, Trypanosoma cruzi triggers a strong immune response that has both protective and pathological consequences. In this work, several important questions regarding protective immunity are reviewed.
Basombrío, Miguel Ángel Manuel +2 more
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Prevalence of Haemoparasites among Blood Donors in Calabar, Nigeria
Medical Laboratory Journal, 2021 Background and objectives: Voluntary blood donation is the main source of blood and its components globally. Blood transfusion is essential for management of various diseases but remains as one of the most important causes of disease transmission.
Paul Inyang-Etoh +3 more
doaj
Giant FAZ10 is required for flagellum attachment zone stabilization and furrow positioning in Trypanosoma brucei [PDF]
, 2017 The flagellum and flagellum attachment zone (FAZ) are important cytoskeletal structures in trypanosomatids, being required for motility, cell division and cell morphogenesis.
Baqui, Munira M.A. +3 more
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