Results 51 to 60 of about 167,875 (235)

Ubiquitination and the Proteasome as Drug Targets in Trypanosomatid Diseases

Frontiers in Chemistry, 2021
The eukaryotic pathogens Trypanosoma brucei, Trypanosoma cruzi and Leishmania are responsible for debilitating diseases that affect millions of people worldwide.
Marie-José Bijlmakers
doaj   +1 more source

Molecular epidemiology of African sleeping sickness [PDF]

, 2009
Human sleeping sickness in Africa, caused by Trypanosoma brucei spp. raises a number of questions. Despite the widespread distribution of the tsetse vectors and animal trypanosomiasis, human disease is only found in discrete foci which periodically give ...
A. TAIT, G. HIDE, Gibson, Hide, Mehlitz, Morrison   +5 more
core   +2 more sources

Molecular and antigenic characterization of Trypanosoma cruzi TolT proteins [PDF]

, 2018
Background: TolT was originally described as a Trypanosoma cruzi molecule that accumulated on the trypomastigote flagellum bearing similarity to bacterial TolA colicins receptors.
Agüero, Fernan Gonzalo, Altcheh, Jaime Marcelo, Balouz, Virginia, Buscaglia, Carlos Andres, Camara, María de los Milagros, Campetella, Oscar Eduardo, Canepa, Gaspar Exequiel, Carlevaro, Giannina Alejandra, Carmona, Santiago Javier, Ciocchini, Andres Eduardo, Cortina, María Eugenia, Lobo, Mabel Maite, Melli, Luciano Jorge, Mucci, Juan Sebastián   +13 more
core   +1 more source

Chagas disease reactivation in a heart transplant patient infected by domestic Trypanosoma cruzi discrete typing unit I (TcIDOM) [PDF]

, 2015
Background Trypanosoma cruzi, causative agent of Chagas disease, displays high intraspecific genetic diversity: six genetic lineages or discrete typing units (DTUs) are currently recognized, termed TcI through TcVI.
Bhattacharyya, T., Burleigh, B.A., Costales, J.A., Garcia-Perez, J., Kotton, C.N., Llewellyn, M.S., Messenger, L.A., Zurita-Leal, A.C.   +7 more
core   +2 more sources

Trypanosoma evansi as a Major Cause of Animal Trypanosomiasis: A Comprehensive Review

Jurnal Medik Veteriner
Trypanosomiasis caused by Trypanosoma evansi is a major protozoan illness that affects animals worldwide. It is also referred to as “surra” and affects a variety if wild and domestic animals such as sheep, cattle, goats, dogs, buffaloes, pigs, elephants,
Sunaryo Hadi Warsito, Aswin Rafif Khairullah, Mirni Lamid, Mohammad Anam Al-Arif, Herry Agoes Hermadi, Widya Paramita Lokapirnasari, Muhammad Khaliim Jati Kusala, Syahputra Wibowo, Siti Rani Ayuti, Bantari Wisynu Kusuma Wardhani, Ima Fauziah, Sheila Marty Yanestria, Ikechukwu Benjamin Moses, Agung Prasetyo, Suhita Aryaloka, Kartika Afrida Fauzia, Riza Zainuddin Ahmad, Dea Anita Ariani Kurniasih   +17 more
doaj   +1 more source

Highly Localized Enrichment of Trypanosoma brucei Parasites Using Dielectrophoresis

Micromachines, 2020
Human African trypanosomiasis (HAT), also known as sleeping sickness, is a vector-borne neglected tropical disease endemic to rural sub-Saharan Africa.
Devin Keck, Callie Stuart, Josie Duncan, Emily Gullette, Rodrigo Martinez-Duarte   +4 more
doaj   +1 more source

Molecular epidemiology of domestic and sylvatic Trypanosoma cruzi infection in rural northwestern Argentina [PDF]

, 2008
Genetic diversity of Trypanosoma cruzi populations and parasite transmission dynamics have been well documented throughout the Americas, but few studies have been conducted in the Gran Chaco ecoregion, one of the most highly endemic areas for Chagas ...
Cardinal, Marta Victoria, Ceballos, Leonardo A., Gurtler, Ricardo Esteban, Kitron, Uriel D., Lanati, Leonardo, Lauricella, Marta A., Levin, Mariano Jorge, Marcet, Paula Lorena, Schijman, Alejandro Gabriel   +8 more
core   +1 more source

Detection of Trypanosoma spp. in Bandicota indica from the Thai-Myanmar border area, Mae Sot District Tak Province, Thailand

Asian Pacific Journal of Tropical Medicine, 2019
Objective: To investigate the prevalence of trypanosome infection and their phylogeny in Bandicota indica rats from the cadmium-contaminated area of Mae Sot and the Myanmar border.
Phuangphet Waree Molee, Natthiya Sakulsak, Somchai Saengamnatdej   +2 more
doaj   +1 more source

Broadening the spectrum of ivermectin: Its effect on Trypanosoma cruzi and related trypanosomatids

Frontiers in Cellular and Infection Microbiology, 2022
Chagas disease is an endemic American parasitosis, caused by Trypanosoma cruzi. The current therapies, benznidazole (BZN) and nifurtimox (NFX), show limited efficacy and multiple side effects. Thus, there is a need to develop new trypanocidal strategies.
Laura Fraccaroli, María Daniela Ruiz, Virginia Gabriela Perdomo, Agustina Nicole Clausi, Darío Emmanuel Balcazar, Luciana Larocca, Carolina Carrillo   +6 more
doaj   +1 more source

Identification of novel components of Trypanosoma brucei editosomes [PDF]

, 2003
The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates that occurs during RNA editing in trypanosomatids. We report the identification of nine novel editosome proteins in Trypanosoma brucei.
Carmean, Nicole, Ernst, Nancy L, Panigrahi, Aswini K, Salavati, Reza, Schnaufer, Achim, Stuart, Kenneth, Wang, Bingbing   +6 more
core   +2 more sources