Results 231 to 240 of about 58,854 (251)

cAMP signalling in Trypanosoma brucei

International Journal for Parasitology, 2001
Cyclic AMP was the first second messenger to be identified. After five decades of research, much is currently known about its biological functions and clinical implications. Several components of the cAMP signalling pathways, such as the G-protein coupled receptors and the phosphodiesterases, have become sensitive and specific drug targets for a host ...
T, Seebeck, K, Gong, S, Kunz, R, Schaub, T, Shalaby, R, Zoraghi   +5 more
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Genetic exchange in Trypanosoma brucei

Parasitology Today, 1990
The discovery of genetic exchange in African trypanosomes belonging to the Trypanosoma brucei group is an important development in our understanding of these organisms. Genetic exchange is a feature of major importance in relation to population structure and speciation.
A, Tait, C M, Turner
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Tubulin mRNAs of Trypanosoma brucei

Journal of Molecular Biology, 1986
The tubulin genes of Trypanosoma brucei are located in a single, tightly packed cluster of ten tandemly arranged alternating alpha and beta-genes. No tubulin genes are detected outside the clustered array. Therefore, the cluster can be assumed to be the locus of tubulin gene expression.
M, Imboden, B, Blum, T, DeLange, R, Braun, T, Seebeck   +4 more
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Stable transformation of Trypanosoma brucei

Molecular and Biochemical Parasitology, 1993
We have further analyzed parameters affecting stable transformation of Trypanosoma brucei. Linear DNA was much more efficient than circular DNA and in the vast majority of transformants analyzed the plasmid DNA had inserted into the chromosomes by homologous recombination.
ten Asbroek, A. L., Mol, C. A., Kieft, R., Borst, P.   +3 more
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Enzymatic Targets in Trypanosoma brucei

Current Protein & Peptide Science, 2016
One of the most neglected disease is the Sleeping sickness or Human African Trypanosomiasis (HAT), which is mostly restricted to poor regions of Africa. The disease is caused by parasitic infection with Trypanosoma brucei (T. brucei), and is acquired through the bite of the tsetse fly.
Luciana, Scotti, Francisco J B, Mendonça, Marcelo S, da Silva, Marcus T, Scotti   +3 more
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Glycolysis in Trypanosoma brucei

European Journal of Biochemistry, 1980
The possibility that the glycosomes present in the bloodstream form of Trypanosoma brucei [Opperdoes, F. R. and Borst, P. (1977) FEBS Lett. 80, 360–364] constitute a separate pool of glycolytic intermediates within the cell was investigated.In titrations of intact cells with digitonin, a differential activation of glycolytic enzymes was observed ...
N, Visser, F R, Opperdoes
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Self-fertilisation in Trypanosoma brucei

Molecular and Biochemical Parasitology, 1996
We have investigated whether Trypanosoma brucei can undergo self-fertilisation. A group of 27 metacyclic clones derived from the tsetse transmission of a mixture of two genetically marked stocks was analysed and 22 clones were observed to be of non-hybrid phenotype.
A, Tait, N, Buchanan, G, Hide, C M, Turner   +3 more
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The coatomer of Trypanosoma brucei

Molecular and Biochemical Parasitology, 2001
Coatomer is a multisubunit complex involved in trafficking of vesicles between the endoplasmatic reticulum and the Golgi apparatus. From sequence homologies, all seven subunits, alpha-, beta-, beta'-, gamma-, delta-, epsilon-, and zeta-COP, are encoded in the genome of Trypanosoma brucei.
A G, Maier, H, Webb, M, Ding, M, Bremser, M, Carrington, C, Clayton   +5 more
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Threonine uptake in Trypanosoma brucei

Molecular and Biochemical Parasitology, 1984
Threonine uptake by the parasitic protozoan Trypanosoma brucei has been assessed using an oil-phase separation technique for measuring rapid amino acid fluxes. It was shown that the storage conditions for the organism were critical for the production of reproducible data.
S P, Fricker, S E, Jones, J C, Ellory, J M, Angus, R A, Klein   +4 more
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Malleable Mitochondrion of Trypanosoma brucei

2015
The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list of necessary mitochondrial processes is steadily growing. Here, we summarize the current knowledge of mitochondrial biology of an early-branching parasitic protist, Trypanosoma brucei, a causative agent of serious human and cattle diseases.
Zdeněk, Verner, Somsuvro, Basu, Corinna, Benz, Sameer, Dixit, Eva, Dobáková, Drahomíra, Faktorová, Hassan, Hashimi, Eva, Horáková, Zhenqiu, Huang, Zdeněk, Paris, Priscila, Peña-Diaz, Lucie, Ridlon, Jiří, Týč, David, Wildridge, Alena, Zíková, Julius, Lukeš   +15 more
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