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Journal of Parasitology, 2011
Mammalian immune responses to Trypanosoma brucei infection are important to control of the disease. In rats infected with T. brucei gambiense (Wellcome strain; WS) or T. brucei brucei (interleukin-tat 1.4 strain [ILS]), a marked increase in the number of macrophages in the spleen can be observed.
Hiroshi Nakagawa +5 more
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Mammalian immune responses to Trypanosoma brucei infection are important to control of the disease. In rats infected with T. brucei gambiense (Wellcome strain; WS) or T. brucei brucei (interleukin-tat 1.4 strain [ILS]), a marked increase in the number of macrophages in the spleen can be observed.
Hiroshi Nakagawa +5 more
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Molecular and Biochemical Parasitology, 1989
Restriction fragment length polymorphism (RFLP) has been analysed in Trypanosoma brucei DNA following hybridization with different DNA probes. This polymorphism seems to be due to allelic variation, and not to variation between sequence duplicates, since the genomic environment of the probed polymorphic fragments is conserved over considerable ...
Paindavoine, Pascale +4 more
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Restriction fragment length polymorphism (RFLP) has been analysed in Trypanosoma brucei DNA following hybridization with different DNA probes. This polymorphism seems to be due to allelic variation, and not to variation between sequence duplicates, since the genomic environment of the probed polymorphic fragments is conserved over considerable ...
Paindavoine, Pascale +4 more
openaire +3 more sources
Biosynthesis of Trypanothione in Trypanosoma brucei brucei
Biological Chemistry, 2003Trypanothione [T(SH)2], the major redox mediator in pathogenic trypanosomatids, is synthetized stepwise by two distinct enzymes in Crithidia fasciculata, while in Trypanosoma cruzi a single enzyme catalyzes both steps. A full-length reading frame presumed to encode trypanothione synthetase (TryS) was obtained by PCR using DNA of T.
Ulrich Menge +2 more
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Experimental Parasitology, 1992
Macrophages collected from BCG-infected mice or exposed in vitro to interferon-gamma plus lipopolysaccharide developed a cytostatic activity on Trypanosoma brucei gambiense and Trypanosoma brucei brucei. This trypanostatic activity of activated macrophages was inhibited by addition of N-monomethyl-L-arginine, an inhibitor of the L-arginine-nitric oxide
Bernard Veyret +5 more
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Macrophages collected from BCG-infected mice or exposed in vitro to interferon-gamma plus lipopolysaccharide developed a cytostatic activity on Trypanosoma brucei gambiense and Trypanosoma brucei brucei. This trypanostatic activity of activated macrophages was inhibited by addition of N-monomethyl-L-arginine, an inhibitor of the L-arginine-nitric oxide
Bernard Veyret +5 more
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Effect of putrescine on the respiration of Trypanosoma brucei brucei
Molecular and Biochemical Parasitology, 1986When bloodstream forms of Trypanosoma brucei brucei were exposed to exogenous putrescine for 24 h during in vitro culture, the rate of O2 consumption increased significantly in a concentration-related and time-dependent manner. Trypanosomes cultured with 100 microM DL-alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine ...
Bruce F. Giffin +2 more
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Trypanosoma brucei and the nervous system
Trends in Neurosciences, 1994African sleeping sickness, characterized by a peculiar pain syndrome and prominent neuropsychiatric symptoms, is caused by the parasite Trypanosoma brucei (T.b.). In experimental T.b. infections, a molecule released from the trypanosomes has been isolated that binds to the CD8 molecule of T cells, whereby T cells are activated to secrete interferon ...
Bentivoglio M. +3 more
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cAMP signalling in Trypanosoma brucei
International Journal for Parasitology, 2001Cyclic AMP was the first second messenger to be identified. After five decades of research, much is currently known about its biological functions and clinical implications. Several components of the cAMP signalling pathways, such as the G-protein coupled receptors and the phosphodiesterases, have become sensitive and specific drug targets for a host ...
Rahel Schaub +5 more
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The Ubiquitin-Ligase System in Trypanosoma Brucei Brucei
The American Journal of Tropical Medicine and Hygiene, 1993The question of whether the African trypanosome Trypanosoma brucei brucei utilizes a ubiquitin-ligase system to conjugate the 8,500-dalton protein ubiquitin to other proteins has not been investigated. Using 125I-labeled ubiquitin and gel electrophoresis (sodium dodecyl sulfate and acetic acid, urea, Triton X-100), we looked for the incorporation of ...
D.J. Lowrie +2 more
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Characterisation of pentamidine-resistant Trypanosoma brucei brucei
Molecular and Biochemical Parasitology, 1995Following selection in vitro by exposure to increasing concentrations of the aromatic diamidine pentamidine, a Trypanosoma brucei brucei clone has been characterised in vivo and in vitro. The resistant clone, designated T.b. brucei S427/118/PR32.6, was found to be less virulent than the parental clone T.b.
Berger, Bradley J. +2 more
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A successful backcross in Trypanosoma brucei
Molecular and Biochemical Parasitology, 1995Genetic exchange can take place between different strains of Trypanosoma brucei ssp. when they are cotransmitted via the tsetse fly vector, but the mechanism and limits of compatibility between strains are ill-defined as yet. Following the recovery of several hybrid genotypes with single drug resistance from a cross of drug resistant parental strains ...
G. D. Kanmogne +2 more
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