Results 141 to 150 of about 32,780 (234)

Changes in serum biochemical parameters of experimental Trypanosoma brucei brucei-infected Nigerian indigenous dogs administered multispecies probiotic and diminazene aceturate. [PDF]

J Parasit Dis, 2021
Kolawole BJ, Nwoha RIO, Erin JP, Orakpoghenor O.   +3 more
europepmc   +1 more source

Q586B2 is a crucial virulence factor during the early stages of Trypanosoma brucei infection that is conserved amongst trypanosomatids

Nature Communications
Human African trypanosomiasis or sleeping sickness, caused by the protozoan parasite Trypanosoma brucei, is characterized by the manipulation of the host’s immune response to ensure parasite invasion and persistence. Uncovering key molecules that support
Benoit Stijlemans, Patrick De Baetselier, Inge Van Molle, Laurence Lecordier, Erika Hendrickx, Ema Romão, Cécile Vincke, Wendy Baetens, Steve Schoonooghe, Gholamreza Hassanzadeh-Ghassabeh, Hannelie Korf, Marie Wallays, Joar E. Pinto Torres, David Perez-Morga, Lea Brys, Oscar Campetella, María S. Leguizamón, Mathieu Claes, Sarah Hendrickx, Dorien Mabille, Guy Caljon, Han Remaut, Kim Roelants, Stefan Magez, Jo A. Van Ginderachter, Carl De Trez   +25 more
doaj   +1 more source

Comparative effects of artemether and in combination with diminazene aceturate in the treatment of experimental Trypanosoma brucei brucei infection in Wistar rats. [PDF]

J Parasit Dis, 2021
Jolayemi KO, Mamman M, Sani D, Okoronkwo MO, Udechukwu CC, Orakpoghenor O.   +5 more
europepmc   +1 more source

2,4-Bis{4-[(dialkylaminoalkyl)aminomethyl]phenyl}-7-substituted-7H-pyrrolo[2,3-d]pyrimidine Derivatives: Synthesis and Biological Evaluation as Novel Antiprotozoal Agents by Potentially Targeting G-Quadruplex

Scientia Pharmaceutica
A series of substituted pyrrolo[2,3-d]pyrimidines was designed, synthesized, and evaluated in vitro against two protozoan parasites: Plasmodium falciparum and Trypanosoma brucei brucei.
Jean Guillon, Solène Savrimoutou, Patrice Agnamey, Vittoria Milano, Céline Damiani, Luisa Ronga, Marie Hanot, Sandra Albenque, Tshering Zangmo, Sarah Monic, Noël Pinaud, Lindita Lari, Mathieu Marchivie, Stéphane Moreau, Jean-Louis Mergny, Serge Moukha, Pascale Dozolme, Clotilde Boudot, Bertrand Courtioux, Anita Cohen, Pascal Sonnet   +20 more
doaj   +1 more source

Blocking Variant Surface Glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation

, 2009
Background: The African trypanosome Trypanosoma brucei is covered with a dense layer of Variant Surface Glycoprotein (VSG), which protects it from lysis by host complement via the alternative pathway in the mammalian bloodstream.
Gluenz, E, Rudenko, G, Gluenz Eva, Terry K Smith, Shulamit Michaeli, Susanne Kramer, Michaeli, Shulamit, Terry, Stephen, Terry K. Smith, Michaeli, S, Eva Gluenz, Smith, Terry K., Vasileva, N, Nadina Vasileva, Mark Carrington, Michaeli Shulamit, Vasileva, Nadina, Carrington, M, Stephen Terry, Rudenko Gloria, Gull Keith, Portman, N, Gluenz, Eva, Keith Gull, Terry, S, Smith Terry K., Neil Portman, Gull, K, Kramer, S, Portman, Neil, Smith, TK, Smith, Terry K, Rudenko, Gloria, Terry Stephen, Vasileva Nadina, Gull, Keith, Carrington Mark, Carrington, Mark, Kramer, Susanne, Terry K. Smith, Portman Neil, Kramer Susanne, Gloria Rudenko   +42 more
core   +1 more source

Distinct roles for two RAD51-related genes in Trypanosoma brucei antigenic variation

, 2005
In Trypanosoma brucei, DNA recombination is crucial in antigenic variation, a strategy for evading the mammalian host immune system found in a wide variety of pathogens.
Proudfoot, C, McCulloch, Richard, Proudfoot, Christopher, McCulloch, R   +3 more
core   +1 more source

Cholesterol Efflux Decreases TLR4-Target Gene Expression in Cultured Macrophages Exposed to T. brucei Ghosts

Microorganisms
Trypanosoma brucei causes African trypanosomiasis in humans. Infection with T. brucei elicits a potent pro-inflammatory immune response within infected human hosts, and this response is thought to at least be partially due to Toll-like receptor (TLR ...
Lawrence Fernando, Jing Echesabal-Chen, Murphy Miller, Rhonda Reigers Powell, Terri Bruce, Apurba Paul, Nava Poudyal, Joshua Saliutama, Kristina Parman, Kimberly S. Paul, Alexis Stamatikos   +10 more
doaj   +1 more source

Trypanosoma brucei brucei Induces Polymorphonuclear Neutrophil Activation and Neutrophil Extracellular Traps Release. [PDF]

Front Immunol, 2020
Grob D, Conejeros I, Velásquez ZD, Preußer C, Gärtner U, Alarcón P, Burgos RA, Hermosilla C, Taubert A.   +8 more
europepmc   +1 more source

Identification of megacerotonic acid and a quinazoline derivative from Universal Natural Product Database as potential inhibitors of Trypanosoma brucei brucei alternative oxidase: molecular docking, molecular dynamic simulation and MM/PBSA analysis. [PDF]

J Biomol Struct Dyn, 2023
Adamu RM, Ibrahim B, Ibrahim MA, Balogun EO.   +3 more
europepmc   +1 more source

Individual and combined anti-trypanosomal effects of arteether and diminazene aceturate in the treatment of experimental Trypanosoma brucei brucei infection in rats. [PDF]

Vet World, 2020
Egbe-Nwiyi TN, Abalaka SE, Sani NA, Tenuche OZ, Idoko IS.   +4 more
europepmc   +1 more source