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Mechanism of Trypanosoma brucei gambiense resistance to human serum
Nature, 2013The African parasite Trypanosoma brucei gambiense accounts for 97% of human sleeping sickness cases. T. b. gambiense resists the specific human innate immunity acting against several other tsetse-fly-transmitted trypanosome species such as T. b. brucei, the causative agent of nagana disease in cattle.
Pierrick Uzureau +21 more
semanticscholar +5 more sources
Purine metabolism in Trypanosoma brucei gambiense
Biochimica et Biophysica Acta (BBA) - General Subjects, 1982Abstract The procyclic forms of Trypanosoma brucei gambiense do not incorporate glycine or serine into ribonucleotides. Although de novo purine synthesis does not occur, all purine bases and ribonucleotides are interconverted, indicating the presence of active salvage pathways. Guanine is actively deaminated to xanthine by guanase activity.
Randolph L. Berens +2 more
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Molecular and Biochemical Parasitology, 1989
Restriction fragment length polymorphism (RFLP) has been analysed in Trypanosoma brucei DNA following hybridization with different DNA probes. This polymorphism seems to be due to allelic variation, and not to variation between sequence duplicates, since the genomic environment of the probed polymorphic fragments is conserved over considerable ...
Paindavoine, Pascale +4 more
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Restriction fragment length polymorphism (RFLP) has been analysed in Trypanosoma brucei DNA following hybridization with different DNA probes. This polymorphism seems to be due to allelic variation, and not to variation between sequence duplicates, since the genomic environment of the probed polymorphic fragments is conserved over considerable ...
Paindavoine, Pascale +4 more
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Journal of Parasitology, 2011
Mammalian immune responses to Trypanosoma brucei infection are important to control of the disease. In rats infected with T. brucei gambiense (Wellcome strain; WS) or T. brucei brucei (interleukin-tat 1.4 strain [ILS]), a marked increase in the number of macrophages in the spleen can be observed.
Hiroshi Nakagawa +5 more
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Mammalian immune responses to Trypanosoma brucei infection are important to control of the disease. In rats infected with T. brucei gambiense (Wellcome strain; WS) or T. brucei brucei (interleukin-tat 1.4 strain [ILS]), a marked increase in the number of macrophages in the spleen can be observed.
Hiroshi Nakagawa +5 more
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Experimental Parasitology, 1992
Macrophages collected from BCG-infected mice or exposed in vitro to interferon-gamma plus lipopolysaccharide developed a cytostatic activity on Trypanosoma brucei gambiense and Trypanosoma brucei brucei. This trypanostatic activity of activated macrophages was inhibited by addition of N-monomethyl-L-arginine, an inhibitor of the L-arginine-nitric oxide
Bernard Veyret +5 more
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Macrophages collected from BCG-infected mice or exposed in vitro to interferon-gamma plus lipopolysaccharide developed a cytostatic activity on Trypanosoma brucei gambiense and Trypanosoma brucei brucei. This trypanostatic activity of activated macrophages was inhibited by addition of N-monomethyl-L-arginine, an inhibitor of the L-arginine-nitric oxide
Bernard Veyret +5 more
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"Trypanosoma brucei gambiense" : cerebral immunopathology in mice
Acta tropica, 1982Ninety outbred white adult female mice were infected with Trypanosoma brucei gambiense (GUMS 2, alias LUMP 1237) originating from a Zairian patient and known to produce a low parasitaemia in rodents. The development of cerebral trypanosomiasis was independent upon the number of parasites inoculated per mouse.
A A, Poltera, A, Hochmann, P H, Lambert
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Mechanism of Lysis of Trypanosoma brucei gambiense by Human Serum
The Journal of Parasitology, 1994Resistance to lysis by human serum (HS) is an important parameter used to distinguish Trypanosoma brucei brucei from both Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Neither the exact nature of the trypanolytic factor (TLF) nor the mechanism of action by which HS lyses susceptible trypanosomes is well understood.
Juan Carlos Ortiz-Ordóñez +3 more
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The role of immunoglobulins in immunity to Trypanosoma brucei gambiense
International Journal for Parasitology, 1977Abstract The effects of IgM and IgG antibody molecules were compared on a weight basis by both agglutination and in vitro protection tests. It was shown that IgM is a better agglutinating antibody and in the presence of complement is also a better neutralizing antibody.
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Transactions of the Royal Society of Tropical Medicine and Hygiene, 1967
Abstract Trypanosoma brucei, T. rhodesiense and T. gambiense were transmitted by Glossina palpalis to 3 chimpanzees; the strain of T. brucei was shown to be non-infective to man. High parasitaemias developed in the chimpanzee infected with T.
D.G. Godfrey, R. Killick-Kendrick
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Abstract Trypanosoma brucei, T. rhodesiense and T. gambiense were transmitted by Glossina palpalis to 3 chimpanzees; the strain of T. brucei was shown to be non-infective to man. High parasitaemias developed in the chimpanzee infected with T.
D.G. Godfrey, R. Killick-Kendrick
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DIFLUOROMETHYLORNITHINE FOR ARSENO-RESISTANT TRYPANOSOMA BRUCEI GAMBIENSE SLEEPING SICKNESS
The Lancet, 198726 patients with arseno-resistant Trypanosoma brucei gambiense trypanosomiasis were treated with difluoromethylornithine (eflornithine), an inhibitor of ornithine decarboxylase, given intravenously, then orally. There was rapid disappearance of trypanosomes in the cerebrospinal fluid (CSF), gradual decrease of CSF lymphocytosis, and parallel ...
C. Guern +4 more
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