Results 181 to 190 of about 18,366 (207)

Nitric oxide-mediated cytostatic activity on Trypanosoma brucei gambiense and Trypanosoma brucei brucei

Experimental Parasitology, 1992
Macrophages collected from BCG-infected mice or exposed in vitro to interferon-gamma plus lipopolysaccharide developed a cytostatic activity on Trypanosoma brucei gambiense and Trypanosoma brucei brucei. This trypanostatic activity of activated macrophages was inhibited by addition of N-monomethyl-L-arginine, an inhibitor of the L-arginine-nitric oxide
P, Vincendeau, S, Daulouède, B, Veyret, M L, Darde, B, Bouteille, J L, Lemesre   +5 more
openaire   +2 more sources

Differential Effects of Trypanosoma brucei gambiense and Trypanosoma brucei brucei on Rat Macrophages

Journal of Parasitology, 2011
Mammalian immune responses to Trypanosoma brucei infection are important to control of the disease. In rats infected with T. brucei gambiense (Wellcome strain; WS) or T. brucei brucei (interleukin-tat 1.4 strain [ILS]), a marked increase in the number of macrophages in the spleen can be observed.
Kazuhiko, Nishimura, Haruna, Nakaya, Hiroshi, Nakagawa, Saburo, Matsuo, Yoshihiro, Ohnishi, Shinji, Yamasaki   +5 more
openaire   +2 more sources

"Trypanosoma brucei gambiense" : cerebral immunopathology in mice

Acta tropica, 1982
Ninety outbred white adult female mice were infected with Trypanosoma brucei gambiense (GUMS 2, alias LUMP 1237) originating from a Zairian patient and known to produce a low parasitaemia in rodents. The development of cerebral trypanosomiasis was independent upon the number of parasites inoculated per mouse.
A A, Poltera, A, Hochmann, P H, Lambert
openaire   +2 more sources

Phospholipase A₂fromTrypanosoma brucei gambienseandTrypanosoma brucei brucei: Inhibition by Organotins

Journal of Enzyme Inhibition, 2001
Activity and kinetics of phospholipase A2 (PLA2) from Trypanosoma brucei gambiense (Wellcome strain) and Trypanosoma brucei brucei (GUTat 3.1) were examined using two different fluorescent substrates. The activity in the supernatants of sonicated parasites was Ca2+-independent, strongly stimulated by Triton X-100 with optimum activity at 37 degrees C ...
M N, Shuaibu, H, Kanbara, T, Yanagi, D A, Ameh, J J, Bonire, A J, Nok   +5 more
openaire   +2 more sources

Mechanism of Trypanosoma brucei gambiense resistance to human serum

Nature, 2013
The African parasite Trypanosoma brucei gambiense accounts for 97% of human sleeping sickness cases. T. b. gambiense resists the specific human innate immunity acting against several other tsetse-fly-transmitted trypanosome species such as T. b. brucei, the causative agent of nagana disease in cattle.
Uzureau, Pierrick, Uzureau, Sophie, Lecordier, Laurence, Fontaine, Frederic, Tebabi, Patricia, Homble, Fabrice, Grelard, Axelle, Zhendre, Vanessa, Nolan, Derek P., Lins, Laurence, Crowet, Jean-Marc, Pays, Annette, Felu, Cecile, Poelvoorde, Philippe, Vanhollebeke, Benoit, Moestrup, Soren K., Lyngso, Jeppe, Pedersen, Jan Skov, Mottram, Jeremy C., Dufourc, Erick J., Perez-Morga, David, Pays, Etienne   +21 more
openaire   +4 more sources

DIFLUOROMETHYLORNITHINE FOR ARSENO-RESISTANT TRYPANOSOMA BRUCEI GAMBIENSE SLEEPING SICKNESS

The Lancet, 1987
26 patients with arseno-resistant Trypanosoma brucei gambiense trypanosomiasis were treated with difluoromethylornithine (eflornithine), an inhibitor of ornithine decarboxylase, given intravenously, then orally. There was rapid disappearance of trypanosomes in the cerebrospinal fluid (CSF), gradual decrease of CSF lymphocytosis, and parallel ...
J, Pepin, F, Milord, C, Guern, P J, Schechter   +3 more
openaire   +2 more sources

Immunological control of chronic "Trypanosoma brucei gambiense" in outbred rodents

Acta tropica, 1984
Recent human isolates of Trypanosoma brucei gambiense generally fail to become or remain patent in laboratory rodents. The purpose of this study was to determine if this was due to acquired immunity and if so which immunosuppressive method was the most efficient in raising parasitemia levels.
P, Diffley, J O, Scott
openaire   +2 more sources

Epidemiological evidence for immunity following Trypanosoma brucei gambiense sleeping sickness

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1995
In order to investigate whether protective immunity appears after Trypanosoma brucei gambiense sleeping sickness, we undertook a retrospective cohort study of 3 remote villages in central Zaire (total population 1431), in which 38% of all adults had a past history of human African trypanosomiasis.
N, Khonde, J, Pépin, T, Niyonsenga, F, Milord, P, De Wals   +4 more
openaire   +2 more sources

Trypanosoma brucei gambiense excreted/secreted factors impair lipopolysaccharide‐induced maturation and activation of human monocyte‐derived dendritic cells

Parasite immunology (Print), 2019
Trypanosoma brucei gambiense, an extracellular eukaryotic flagellate parasite, is the main etiological agent of human African trypanosomiasis (HAT) or sleeping sickness.
F. Dauchy, C. Contin-Bordes, R. Nzoumbou-Boko, M. Bonhivers, N. Landrein, D. Robinson, J. Rambert, P. Courtois, S. Daulouède, P. Vincendeau   +9 more
semanticscholar   +1 more source

Phenylalanine metabolism in Microtus montanus chronically infected with Trypanosoma brucei gambiense

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1982
1. Alterations in phenylalanine metabolism were observed in Microtus montanus infected with Trypanosoma brucei gambiense. 2. Reductions were found in the incorporation of phenylalanine into free amino acid pools and into proteins of the liver and other organs of infected animals. 3.
J R, Seed, J E, Hall, J, Sechelski
openaire   +2 more sources