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Melarsoprol- and pentamidine-resistant Trypanosoma brucei rhodesiense populations and their cross-resistance

International Journal for Parasitology, 2007
Resistance to melarsoprol and pentamidine was induced in bloodstream-form Trypanosoma brucei rhodesiense STIB 900 in vitro, and drug sensitivity was determined for melarsoprol, pentamidine and furamidine. The resistant populations were also inoculated into immunosuppressed mice to verify infectivity and to monitor whether rodent passage selects for ...
Bernhard, Sonja C.   +3 more
openaire   +4 more sources

The origins, dynamics and generation of Trypanosoma brucei rhodesiense epidemics in East Africa

Parasitology Today, 1996
The history of sleeping sickness in East Africa has provoked controversy not only about the origins and spread of the disease, but also the identity of the causative organisms involved. Molecular methodology(1) has shed new light on the genetic makeup of the organisms involved in recent epidemics.
G, Hide   +3 more
openaire   +2 more sources

Antigenicity and stilbamidine resistance in Trypanosoma brucei rhodesiense

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1973
S, Venkatesan, W E, Ormerod
openaire   +2 more sources

Melarsoprol and reactive encephalopathy in Trypanosoma brucei rhodesiense

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987
Jaime Orlando, Lopes Arroz
openaire   +2 more sources

Suramin and metronidazole in the treatment of Trypanosoma brucei rhodesiense

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988
J, Arroz, M, Djedje
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Relationship between Trypanosoma “brucei” and T. “rhodesiense”

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1980
L, Rickman, F, Kolala
openaire   +2 more sources

Experimental infection with Trypanosoma brucei, Trypanosoma rhodesiense, and Trypanosoma gambiense in beagle-dogs

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1970
F, Evens, R, Marsboom, J, Mortelmans
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Trypanosoma brucei rhodesiense

1991
R. Ringelmann, Beate Heym
openaire   +1 more source

In situ kinetic characterization of methylthioadenosine transport by the adenosine transporter (P2) of the African Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense.

Biochemical pharmacology, 2001
African trypanosomes are parasitic flagellates that live in the connective tissues of the host. Trypanosomes must obtain from their host adenine/adenosine and other nucleosides that can be salvaged through enzymatic cleavage. Methylthioadenosine (MTA) is a byproduct of polyamine metabolism, formed from the donation of an aminopropyl moiety by ...
B, Goldberg   +4 more
openaire   +1 more source

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