Results 151 to 160 of about 59,489 (194)

The action of trypanocidal arsenical drugs on Trypanosoma brucei and Trypanosoma rhodesiense

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1974
Abstract 1. 1. Catabolism of glucose by monomorphic Trypanosoma brucei and pleomorphic T. rhodesiense is inhibited by trivalent organic arsenicals. The utilization of α-oxoglutarate and pyruvate by short stumpy forms of pleomorphic T. rhodesiense is inhibited by similar concentrations of arsenicals. 2. 2.
I W, Flynn, I B, Bowman
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Tropical pyomyositis associated with Trypanosoma brucei rhodesiense infection in a Europid

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1989
A 29-year-old European woman became infected with Trypanosoma brucei rhodesiense in the Luangwa valley, Zambia. Six days after the initial presentation of this infection she developed evidence of tropical pyomyositis (TP). These diseases, both of which are rare in Europids, were satisfactorily treated.
G C Cook
exaly   +3 more sources

Experimental infection of cattle with Trypanosoma brucei rhodesiense

Annals of Tropical Medicine & Parasitology, 1989
Infection of cattle with various stocks of Trypanosoma brucei rhodesiense indicated that 49% developed a fatal CNS disease comparable to that found in man. Duration of disease ranged from 85 to 1613 days post infection. All eight stocks of T. b. rhodesiense tested, including those from Ethiopia and Tanzania, induced CNS disease.
B T, Wellde, M J, Reardon, R M, Kovatch, D A, Chumo, J S, Williams, W L, Boyce, W T, Hockmeyer, D E, Wykoff   +7 more
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Activity of Extracts and Naphthoquinones from Kigelia pinnata Against Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense

Planta Medica, 1999
Dichloromethane extracts of the root bark and stem bark of Kigelia pinnata collected from Zimbabwe exhibited antitrypanosomal activity against Trypanosoma brucei brucei in vitro. Activity-guided fractionation led to the isolation of four naphthoquinones from both the root and stem bark of the plant.
S V, Moideen, P J, Houghton, P, Rock, S L, Croft, F, Aboagye-Nyame   +4 more
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Will the real Trypanosoma brucei rhodesiense please step forward?

Trends in Parasitology, 2002
The sleeping sickness trypanosomes Trypanosoma brucei rhodesiense and T. brucei gambiense are morphologically indistinguishable from each other and from T. brucei brucei, which does not infect humans. The relationships between these three subspecies have been controversial. Several years ago, the characterization of T.
Wendy Gibson
exaly   +3 more sources

Expression site associated genes of Trypanosoma brucei rhodesiense

Molecular and Biochemical Parasitology, 1989
Upstream of at least some telomere-linked genes for the variant surface glycoproteins (VSGs) of African trypanosomes are expression site associated genes (ESAGs) whose transcription is co-ordinated with the transcription of the adjacent VSG gene [Cully et al. (1985) Cell 42, 173-182]. The function of the corresponding ESAG proteins is not known.
H J, Son, G A, Cook, T, Hall, J E, Donelson   +3 more
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Growth of Pleomorphic Trypanosoma brucei rhodesiense in Irradiated Inbred Mice

The Journal of Parasitology, 1988
It was shown that irradiation (650 rad) of 7 inbred strains of mice did not block the ability of Trypanosoma brucei rhodesiense to transform from the long slender (LS) to the short stumpy (SS) form or alter the plateau in parasitemia. In addition, it was observed that significant differences in parasitemia levels, in the rate of transformation from the
J R, Seed, J, Sechelski
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Experimental Chronic Trypanosoma brucei rhodesiense Infection in Microtus montanus

The American Journal of Tropical Medicine and Hygiene, 1983
Adult Microtus montanus were inoculated with a recently isolated strain of Trypanosoma brucei rhodesiense of human origin. The animals developed subacute to chronic infection and low-grade parasitemia. Histopathological examination of the heart revealed a severe pancarditis resulting in pronounced weight loss, and survival times of 5-8 weeks ...
J M, Bafort, H, Schmidt
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Activity of Bisphosphonates againstTrypanosoma bruceirhodesiense

Journal of Medicinal Chemistry, 2002
We report the results of a comparative molecular field analysis (CoMFA) investigation of the growth inhibition of the bloodstream form of Trypanosoma brucei rhodesiense trypomastigotes by bisphosphonates. A quantitative three-dimensional structure-activity relationship CoMFA model for a set of 26 bisphosphonates having a range of activity spanning ...
Michael B, Martin, John M, Sanders, Howard, Kendrick, Kate, de Luca-Fradley, Jared C, Lewis, Joshua S, Grimley, Erin M, Van Brussel, Jeffrey R, Olsen, Gary A, Meints, Agnieszka, Burzynska, Pawel, Kafarski, Simon L, Croft, Eric, Oldfield   +12 more
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Electrocardiographic changes in African trypanosomiasis caused by Trypanosoma brucei rhodesiense

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1975
The electrocardiographic findings in 40 patients with Trypanosoma brucei rhodesiense infection are reported. Using rigid diagnostic criteria 7 out of 18 patients (39%) had abnormal electrocardiograms before any form of therapy and 22 of the 40 patients (55%) had abnormal electrocardiograms at some stage of the disease or its treatment.
I G, Jones, M N, Lowenthal, H, Buyst
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