Results 191 to 200 of about 14,712 (223)

Expression site associated genes of Trypanosoma brucei rhodesiense

Molecular and Biochemical Parasitology, 1989
Upstream of at least some telomere-linked genes for the variant surface glycoproteins (VSGs) of African trypanosomes are expression site associated genes (ESAGs) whose transcription is co-ordinated with the transcription of the adjacent VSG gene [Cully et al. (1985) Cell 42, 173-182]. The function of the corresponding ESAG proteins is not known.
H J, Son, G A, Cook, T, Hall, J E, Donelson   +3 more
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Synthesis and evaluation of tetrahydroisoquinoline derivatives against Trypanosoma brucei rhodesiense

European Journal of Medicinal Chemistry, 2021
Human African Trypanosomiasis (HAT) is a neglected tropical disease caused by the parasitic protozoan Trypanosoma brucei (T. b.), and affects communities in sub-Saharan Africa. Previously, analogues of a tetrahydroisoquinoline scaffold were reported as having in vitro activity (IC50 = 0.25-70.5 μM) against T. b. rhodesiense. In this study the synthesis
Danica R. Cullen, Ashlee Gallagher, Caitlin L. Duncan, Jutharat Pengon, Roonglawan Rattanajak, Jason Chaplin, Hendra Gunosewoyo, Sumalee Kamchonwongpaisan, Alan Payne, Mauro Mocerino   +9 more
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Activity of Extracts and Naphthoquinones from Kigelia pinnata Against Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense

Planta Medica, 1999
Dichloromethane extracts of the root bark and stem bark of Kigelia pinnata collected from Zimbabwe exhibited antitrypanosomal activity against Trypanosoma brucei brucei in vitro. Activity-guided fractionation led to the isolation of four naphthoquinones from both the root and stem bark of the plant.
S V, Moideen, P J, Houghton, P, Rock, S L, Croft, F, Aboagye-Nyame   +4 more
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Experimental Chronic Trypanosoma brucei rhodesiense Infection in Microtus montanus

The American Journal of Tropical Medicine and Hygiene, 1983
Adult Microtus montanus were inoculated with a recently isolated strain of Trypanosoma brucei rhodesiense of human origin. The animals developed subacute to chronic infection and low-grade parasitemia. Histopathological examination of the heart revealed a severe pancarditis resulting in pronounced weight loss, and survival times of 5-8 weeks ...
J M, Bafort, H, Schmidt
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Experimental infection of cattle with Trypanosoma brucei rhodesiense

Annals of Tropical Medicine & Parasitology, 1989
Infection of cattle with various stocks of Trypanosoma brucei rhodesiense indicated that 49% developed a fatal CNS disease comparable to that found in man. Duration of disease ranged from 85 to 1613 days post infection. All eight stocks of T. b. rhodesiense tested, including those from Ethiopia and Tanzania, induced CNS disease.
B T, Wellde, M J, Reardon, R M, Kovatch, D A, Chumo, J S, Williams, W L, Boyce, W T, Hockmeyer, D E, Wykoff   +7 more
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Unravelling the origins of Trypanosoma brucei rhodesiense

Trends in Parasitology, 2002
Sleeping sickness in East Africa is caused by Trypanosoma brucei rhodesiense, which occurs in discrete foci of disease throughout the distribution range of its tsetse vector. Outbreaks of the disease can be traced to wild game and, in particular, cattle. Both wild game and cattle harbour the human infective T.
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Activity of Bisphosphonates againstTrypanosoma bruceirhodesiense

Journal of Medicinal Chemistry, 2002
We report the results of a comparative molecular field analysis (CoMFA) investigation of the growth inhibition of the bloodstream form of Trypanosoma brucei rhodesiense trypomastigotes by bisphosphonates. A quantitative three-dimensional structure-activity relationship CoMFA model for a set of 26 bisphosphonates having a range of activity spanning ...
Michael B, Martin, John M, Sanders, Howard, Kendrick, Kate, de Luca-Fradley, Jared C, Lewis, Joshua S, Grimley, Erin M, Van Brussel, Jeffrey R, Olsen, Gary A, Meints, Agnieszka, Burzynska, Pawel, Kafarski, Simon L, Croft, Eric, Oldfield   +12 more
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The effect of spiroarsoranes on Trypanosoma brucei brucei and T. b. rhodesiense

Parasitology Research, 1996
Topical application and intraperitoneal administration of spiroarsoranes were carried out to cure central nervous system (CNS) trypanosomiasis in the chronic Trypanosoma brucei GVR 35 mouse model. Topical application appeared more efficient than intraperitoneal injection. The periods of aparasitaemia after treatment were longer but none of the mice was
P M, Loiseau, F W, Jennings, P, Lubert, J G, Wolf   +3 more
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The action of trypanocidal arsenical drugs on Trypanosoma brucei and Trypanosoma rhodesiense

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1974
Abstract 1. 1. Catabolism of glucose by monomorphic Trypanosoma brucei and pleomorphic T. rhodesiense is inhibited by trivalent organic arsenicals. The utilization of α-oxoglutarate and pyruvate by short stumpy forms of pleomorphic T. rhodesiense is inhibited by similar concentrations of arsenicals. 2. 2.
I W, Flynn, I B, Bowman
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Growth of Pleomorphic Trypanosoma brucei rhodesiense in Irradiated Inbred Mice

The Journal of Parasitology, 1988
It was shown that irradiation (650 rad) of 7 inbred strains of mice did not block the ability of Trypanosoma brucei rhodesiense to transform from the long slender (LS) to the short stumpy (SS) form or alter the plateau in parasitemia. In addition, it was observed that significant differences in parasitemia levels, in the rate of transformation from the
J R, Seed, J, Sechelski
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