Results 211 to 220 of about 22,217 (248)
The effect of spiroarsoranes on Trypanosoma brucei brucei and T. b. rhodesiense [PDF]
Parasitology Research, 1996 Topical application and intraperitoneal administration of spiroarsoranes were carried out to cure central nervous system (CNS) trypanosomiasis in the chronic Trypanosoma brucei GVR 35 mouse model. Topical application appeared more efficient than intraperitoneal injection. The periods of aparasitaemia after treatment were longer but none of the mice was
F.W. Jennings +3 more
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Archives of Biochemistry and Biophysics, 2000
Methionine is an essential amino acid for both prokaryotic and eukaryotic organisms; however, little is known concerning its utilization in African trypanosomes, protozoa of the Trypanosoma brucei group. This study explored the Michaelis-Menten kinetic constants for transport and pool formation as well as metabolic utilization of methionine by two ...
Cyrus J. Bacchi +4 more
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Methionine is an essential amino acid for both prokaryotic and eukaryotic organisms; however, little is known concerning its utilization in African trypanosomes, protozoa of the Trypanosoma brucei group. This study explored the Michaelis-Menten kinetic constants for transport and pool formation as well as metabolic utilization of methionine by two ...
Cyrus J. Bacchi +4 more
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The action of trypanocidal arsenical drugs on Trypanosoma brucei and Trypanosoma rhodesiense
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1974Abstract 1. 1. Catabolism of glucose by monomorphic Trypanosoma brucei and pleomorphic T. rhodesiense is inhibited by trivalent organic arsenicals. The utilization of α-oxoglutarate and pyruvate by short stumpy forms of pleomorphic T. rhodesiense is inhibited by similar concentrations of arsenicals. 2. 2.
I.W. Flynn, I.B.R. Bowman
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Experimental infection of cattle with Trypanosoma brucei rhodesiense
Annals of Tropical Medicine & Parasitology, 1989Infection of cattle with various stocks of Trypanosoma brucei rhodesiense indicated that 49% developed a fatal CNS disease comparable to that found in man. Duration of disease ranged from 85 to 1613 days post infection. All eight stocks of T. b. rhodesiense tested, including those from Ethiopia and Tanzania, induced CNS disease.
D. A. Chumo +7 more
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Trypanosoma rhodesiense and T. brucei: Absence of antibodies in chicken embryos
Experimental Parasitology, 1969Abstract With the need to produce trypanosomes of constant antigenic type in mind, the antibody response of chicken embryos infected with Trypanosoma rhodesiense and T. brucei was examined. Embryos were infected at different ages (7–14 days of embryonic life) and sera were collected up to and after hatching. The postinoculation maintenance period
E. Goedbloed, B.A. Southgate
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Unravelling the origins of Trypanosoma brucei rhodesiense
Trends in Parasitology, 2002Sleeping sickness in East Africa is caused by Trypanosoma brucei rhodesiense, which occurs in discrete foci of disease throughout the distribution range of its tsetse vector. Outbreaks of the disease can be traced to wild game and, in particular, cattle. Both wild game and cattle harbour the human infective T.
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Planta Medica, 1999
Dichloromethane extracts of the root bark and stem bark of Kigelia pinnata collected from Zimbabwe exhibited antitrypanosomal activity against Trypanosoma brucei brucei in vitro. Activity-guided fractionation led to the isolation of four naphthoquinones from both the root and stem bark of the plant.
Francis Aboagye-Nyame +4 more
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Dichloromethane extracts of the root bark and stem bark of Kigelia pinnata collected from Zimbabwe exhibited antitrypanosomal activity against Trypanosoma brucei brucei in vitro. Activity-guided fractionation led to the isolation of four naphthoquinones from both the root and stem bark of the plant.
Francis Aboagye-Nyame +4 more
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Expression site associated genes of Trypanosoma brucei rhodesiense
Molecular and Biochemical Parasitology, 1989Upstream of at least some telomere-linked genes for the variant surface glycoproteins (VSGs) of African trypanosomes are expression site associated genes (ESAGs) whose transcription is co-ordinated with the transcription of the adjacent VSG gene [Cully et al. (1985) Cell 42, 173-182]. The function of the corresponding ESAG proteins is not known.
John E. Donelson +3 more
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ChemMedChem, 2020
Starting from the reversible rhodesain inhibitors 1 a–c, which have Ki values towards the target protease in the low‐micromolar range, we have designed a series of peptidomimetics, 2 a–g, that contain a benzodiazepine scaffold as a β‐turn mimetic; they ...
Carla Di Chio +6 more
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Starting from the reversible rhodesain inhibitors 1 a–c, which have Ki values towards the target protease in the low‐micromolar range, we have designed a series of peptidomimetics, 2 a–g, that contain a benzodiazepine scaffold as a β‐turn mimetic; they ...
Carla Di Chio +6 more
semanticscholar +1 more source
Activity of Bisphosphonates againstTrypanosoma bruceirhodesiense
Journal of Medicinal Chemistry, 2002We report the results of a comparative molecular field analysis (CoMFA) investigation of the growth inhibition of the bloodstream form of Trypanosoma brucei rhodesiense trypomastigotes by bisphosphonates. A quantitative three-dimensional structure-activity relationship CoMFA model for a set of 26 bisphosphonates having a range of activity spanning ...
Jared C. Lewis +12 more
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