Results 231 to 240 of about 22,217 (248)

Scoping Studies into the Structure‐Activity Relationship (SAR) of Phenylephrine‐Derived Analogues as Inhibitors of Trypanosoma brucei rhodesiense

, 2016
Human African Trypanosomiasis (HAT) is a disease caused by the parasite Trypanosoma brucei and is classified as a neglected tropical disease of concern in sub-Saharan Africa. A scoping study has been undertaken to develop a preliminary structure activity
D. R. Cullen, Jutharat Pengon, R. Rattanajak, J. Chaplin, S. Kamchonwongpaisan, M. Mocerino   +5 more
semanticscholar   +1 more source

Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense.

European journal of medicinal chemistry, 2022
Carla Di Chio, S. Previti, Giorgio Amendola, Rahul Ravichandran, A. Wagner, S. Cosconati, U. Hellmich, T. Schirmeister, M. Zappalà, R. Ettari   +9 more
semanticscholar   +1 more source

Kinetics ofS-Adenosylmethionine Cellular Transport and Protein Methylation inTrypanosoma brucei bruceiandTrypanosoma brucei rhodesiense

Archives of Biochemistry and Biophysics, 1999
African trypanosomes of the Trypanosoma brucei group are agents of disease in man and animals. They present unique biochemical characteristics such as the need for preformed purines and have extensive salvage mechanisms for nucleoside recovery. In this regard we have shown that trypanosomes have a dedicated transporter for S-adenosylmethionine (AdoMet),
Cyrus J. Bacchi, Nigel Yarlett, Burt Goldberg, Burt Goldberg, Donnna Rattendi, David Lloyd   +5 more
openaire   +3 more sources

The differentiation of Trypanosoma rhodesiense from T. brucei by means of human serum

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1973
Abstract 1. 1. A review is made of the Blood Incubation Infectivity Test (BIIT) introduced by Rickman and Robson (1970) to differentiate Trypanosoma rhodesiense from T. brucei in the laboratory. This test consists of incubating the trypanosomes with human blood and then injecting them into a rat; if the rat becomes infected, the trypanosomes ...
openaire   +3 more sources

Relationship between Trypanosoma “brucei” and T. “rhodesiense”

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1980
Fulberito Kolala, Laurence R. Rickman
openaire   +3 more sources

Infection of tsetse with Trypanosoma brucei rhodesiense and T. b. gambiense

1997
Trypanosoma brucei rhodesiense and T. b. gambiense are salivarian trypanosomes (subgenus Trypanozoon) which are major pathogens of humans causing, respectively, the acute (Rhodesian) and chronic (Gambian) forms of sleeping sickness in Africa. Both trypanosome species are transmitted during feeding via the salivary glands of tsetse flies, both sexes of ...
openaire   +2 more sources

Antigenicity and stilbamidine resistance in Trypanosoma brucei rhodesiense

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1973
W.E. Ormerod, S. Venkatesan
openaire   +3 more sources

Suramin and metronidazole in the treatment of Trypanosoma brucei rhodesiense

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988
J. Arroz, M. Djedje
openaire   +3 more sources

Melarsoprol and reactive encephalopathy in Trypanosoma brucei rhodesiense

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987
Jaime Orlando, Lopes Arroz
openaire   +3 more sources

Apoptosis in procyclic Trypanosoma brucei rhodesiense in vitro.

Cell death and differentiation, 2012
Apoptosis is a phenomenon previously associated exclusively with metazoan organisms. We show here that procyclic insect form Trypanosoma brucei rhodesiense, a protozoan parasite, when treated in vitro with concanavalin A displayed several features normally associated with apoptosis in metazoan cells.
S C, Welburn, C, Dale, D, Ellis, R, Beecroft, T W, Pearson   +4 more
openaire   +1 more source