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Trypanosoma cruzi: circulating antigens [PDF]

open access: yesMemorias do Instituto Oswaldo Cruz, 1981
Circulating antigens were detected in sera of mice experimentally infected with a high close of Trypanosoma cruzi by reaction with sera from chronically infected mice.
V. Bongertz   +2 more
doaj   +4 more sources

Trypanosoma cruzi [PDF]

open access: yesTrends in Parasitology, 2020
Trypanosoma cruzi is the etiological agent of American trypanosomiasis, or Chagas disease, and is transmitted mainly by blood-sucking reduviid insects in endemic countries. Metacyclic trypomastigotes released in the feces during the insect blood meal enter a mammalian host through skin wounds or mucosal membranes and invade sur- rounding cells.
Moretti, Nilmar Silvio UNIFESP   +2 more
openaire   +4 more sources

Broadening the spectrum of ivermectin: Its effect on Trypanosoma cruzi and related trypanosomatids

open access: yesFrontiers in Cellular and Infection Microbiology, 2022
Chagas disease is an endemic American parasitosis, caused by Trypanosoma cruzi. The current therapies, benznidazole (BZN) and nifurtimox (NFX), show limited efficacy and multiple side effects. Thus, there is a need to develop new trypanocidal strategies.
Laura Fraccaroli   +6 more
doaj   +1 more source

Repurposing Carvedilol as a Novel Inhibitor of the Trypanosoma cruzi Autophagy Flux That Affects Parasite Replication and Survival

open access: yesFrontiers in Cellular and Infection Microbiology, 2021
T. cruzi, the causal agent of Chagas disease, is a parasite able to infect different types of host cells and to persist chronically in the tissues of human and animal hosts.
Cynthia Vanesa Rivero   +13 more
doaj   +1 more source

Biological features of TcM: A new Trypanosoma cruzi isolate from Argentina classified into TcV lineage

open access: yesCurrent Research in Microbial Sciences, 2022
Trypanosoma cruzi, the etiologic agent of Chagas disease (CD) presents a wide genetic and phenotypic diversity that is classified into seven lineages or discrete typing units (DTU: TcI to TcVI and Tcbat).
Santiago José Martinez   +5 more
doaj   +1 more source

Induction of Autophagy by Ursolic Acid Promotes the Elimination of Trypanosoma cruzi Amastigotes From Macrophages and Cardiac Cells

open access: yesFrontiers in Cellular and Infection Microbiology, 2022
Chagas disease, caused by the parasite Trypanosoma cruzi, is an infectious illness endemic to Latin America and still lacks an effective treatment for the chronic stage.
María Cristina Vanrell   +8 more
doaj   +1 more source

Alpha-Tubulin Acetylation in Trypanosoma cruzi: A Dynamic Instability of Microtubules Is Required for Replication and Cell Cycle Progression

open access: yesFrontiers in Cellular and Infection Microbiology, 2021
Trypanosomatids have a cytoskeleton arrangement that is simpler than what is found in most eukaryotic cells. However, it is precisely organized and constituted by stable microtubules.
Victoria Lucia Alonso   +13 more
doaj   +1 more source

Endocytic Rabs Are Recruited to the Trypanosoma cruzi Parasitophorous Vacuole and Contribute to the Process of Infection in Non-professional Phagocytic Cells

open access: yesFrontiers in Cellular and Infection Microbiology, 2020
Trypanosoma cruzi is the parasite causative of Chagas disease, a highly disseminated illness endemic in Latin-American countries. T. cruzi has a complex life cycle that involves mammalian hosts and insect vectors both of which exhibits different ...
Betiana Nebaí Salassa   +6 more
doaj   +1 more source

Acute Phase Proteins in Dogs with Natural Infection by Trypanosoma cruzi

open access: yesTropical Medicine and Infectious Disease, 2023
Acute phase proteins have been used as tools for the diagnosis, monitoring, and prognosis of several diseases in domestic animals. However, the dynamics of these proteins in infection by Trypanosoma cruzi, the causative agent of Chagas disease in dogs ...
Pilar Rivadeneira-Barreiro   +8 more
doaj   +1 more source

Precision Health for Chagas Disease: Integrating Parasite and Host Factors to Predict Outcome of Infection and Response to Therapy

open access: yesFrontiers in Cellular and Infection Microbiology, 2020
Chagas disease, caused by the infection with the protozoan parasite Trypanosoma cruzi, is clinically manifested in approximately one-third of infected people by inflammatory heart disease (cardiomyopathy) and, to a minor degree, gastrointestinal tract ...
Santiago J. Martinez   +5 more
doaj   +1 more source

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