Results 1 to 10 of about 144,739 (262)

High prevalence of Trypanosoma cruzi infection in shelter dogs from southern Louisiana, USA

Parasites & Vectors, 2019
Background Chagas disease is a zoonotic disease caused by the protozoan parasite Trypanosoma cruzi. The role of dogs as sentinels has been proposed in multiple regions, as they are a domestic reservoir for T. cruzi.
Ardem Elmayan, Weihong Tu, Brandy Duhon, Preston Marx, Wendy Wolfson, Gary Balsamo, Claudia Herrera, Eric Dumonteil   +7 more
doaj   +2 more sources

Host-parasite interaction: changes in human placental gene expression induced by Trypanosoma cruzi

Parasites & Vectors, 2018
Background Chagas disease is caused by Trypanosoma cruzi, a parasite endemic to Latin America. Most infections occur in children by vector or congenital transmission.
Christian Castillo, Ileana Carrillo, Gabriela Libisch, Natalia Juiz, Alejandro Schijman, Carlos Robello, Ulrike Kemmerling   +6 more
doaj   +2 more sources

Cytochrome c oxidase subunit 1 gene as a DNA barcode for discriminating Trypanosoma cruzi DTUs and closely related species

Parasites & Vectors, 2017
Background The DNA barcoding system using the cytochrome c oxidase subunit 1 mitochondrial gene (cox1 or COI) is highly efficient for discriminating vertebrate and invertebrate species.
Marina Silva Rodrigues, Karina Alessandra Morelli, Ana Maria Jansen   +2 more
doaj   +2 more sources

Broadening the spectrum of ivermectin: Its effect on Trypanosoma cruzi and related trypanosomatids

Frontiers in Cellular and Infection Microbiology, 2022
Chagas disease is an endemic American parasitosis, caused by Trypanosoma cruzi. The current therapies, benznidazole (BZN) and nifurtimox (NFX), show limited efficacy and multiple side effects. Thus, there is a need to develop new trypanocidal strategies.
Laura Fraccaroli, María Daniela Ruiz, Virginia Gabriela Perdomo, Agustina Nicole Clausi, Darío Emmanuel Balcazar, Luciana Larocca, Carolina Carrillo   +6 more
doaj   +1 more source

A Review on the Immunological Response against Trypanosoma cruzi

Pathogens, 2023
Chagas disease is a chronic systemic infection transmitted by Trypanosoma cruzi. Its life cycle consists of different stages in vector insects and host mammals. Trypanosoma cruzi strains cause different clinical manifestations of Chagas disease alongside
G. Macaluso, Francesca Grippi, S. Di Bella, V. Blanda, Francesca Gucciardi, A. Torina, A. Guercio, V. Cannella   +7 more
semanticscholar   +1 more source

Repurposing Carvedilol as a Novel Inhibitor of the Trypanosoma cruzi Autophagy Flux That Affects Parasite Replication and Survival

Frontiers in Cellular and Infection Microbiology, 2021
T. cruzi, the causal agent of Chagas disease, is a parasite able to infect different types of host cells and to persist chronically in the tissues of human and animal hosts.
Cynthia Vanesa Rivero, Cynthia Vanesa Rivero, Santiago José Martínez, Santiago José Martínez, Paul Novick, Juan Agustín Cueto, Betiana Nebaí Salassa, María Cristina Vanrell, Xiaomo Li, Carlos Alberto Labriola, Luis Mariano Polo, David M. Engman, Joachim Clos, Patricia Silvia Romano   +13 more
doaj   +1 more source

Trypanosoma cruzi genetic diversity: impact on transmission cycles and Chagas disease

Memórias do Instituto Oswaldo Cruz, 2022
Trypanosoma cruzi, the agent of Chagas disease (ChD), exhibits remarkable biological and genetic diversity, along with eco-epidemiological complexity. In order to facilitate communication among researchers aiming at the characterisation of biological and
B. Zingales, D. Bartholomeu
semanticscholar   +1 more source

Review on Experimental Treatment Strategies Against Trypanosoma cruzi

Journal of Experimental Pharmacology, 2021
Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma cruzi. Currently, only nitroheterocyclic nifurtimox (NFX) and benznidazole (BNZ) are available for the treatment of Chagas disease, with limitations such as variable ...
A. L. Mazzeti, P. Capelari-Oliveira, M. T. Bahia, V. C. Mosqueira   +3 more
semanticscholar   +1 more source

Biological features of TcM: A new Trypanosoma cruzi isolate from Argentina classified into TcV lineage

Current Research in Microbial Sciences, 2022
Trypanosoma cruzi, the etiologic agent of Chagas disease (CD) presents a wide genetic and phenotypic diversity that is classified into seven lineages or discrete typing units (DTU: TcI to TcVI and Tcbat).
Santiago José Martinez, Gonzalo Nicolás Nardella, Matías Exequiel Rodríguez, Cynthia Vanesa Rivero, Fernán Agüero, Patricia Silvia Romano   +5 more
doaj   +1 more source

Induction of Autophagy by Ursolic Acid Promotes the Elimination of Trypanosoma cruzi Amastigotes From Macrophages and Cardiac Cells

Frontiers in Cellular and Infection Microbiology, 2022
Chagas disease, caused by the parasite Trypanosoma cruzi, is an infectious illness endemic to Latin America and still lacks an effective treatment for the chronic stage.
María Cristina Vanrell, María Cristina Vanrell, Santiago José Martinez, Lucila Ibel Muñoz, Betiana Nebaí Salassa, Betiana Nebaí Salassa, Julián Gambarte Tudela, Patricia Silvia Romano, Patricia Silvia Romano   +8 more
doaj   +1 more source