Results 21 to 30 of about 137,285 (295)
Quantification of Trypanosoma cruzi in Tissue and Trypanosoma cruzi Killing Assay [PDF]
BIO-PROTOCOL, 2017 Infection with Trypanosoma cruzi causes Chagas disease. The methods provided here allow for the quantification of T. cruzi in the liver, heart, and blood of intraperitoneally-infected mice and analysis of the killing activity of the cells infected with T. cruzi in vitro.
Kiyoshi Takeda +2 more
openaire +4 more sources
Frontiers in Cellular and Infection Microbiology, 2020 Chagas disease, caused by the infection with the protozoan parasite Trypanosoma cruzi, is clinically manifested in approximately one-third of infected people by inflammatory heart disease (cardiomyopathy) and, to a minor degree, gastrointestinal tract ...
Santiago J. Martinez +5 more
doaj +1 more source
The N-myristoylome of Trypanosoma cruzi [PDF]
Scientific Reports, 2016 AbstractProtein N-myristoylation is catalysed by N-myristoyltransferase (NMT), an essential and druggable target in Trypanosoma cruzi, the causative agent of Chagas’ disease. Here we have employed whole cell labelling with azidomyristic acid and click chemistry to identify N-myristoylated proteins in different life cycle stages of the parasite.
Roberts, Adam J., Fairlamb, Alan
openaire +4 more sources
Chagas Disease Diagnostic Applications: Present Knowledge and Future Steps [PDF]
, 2016 Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating illness of major significance throughout Latin America and an emergent threat to global public health.
Balouz, Virginia +2 more
core +1 more source
Phylogenetic analysis of Bolivian bat trypanosomes of the subgenus schizotrypanum based on cytochrome B sequence and minicircle analyses. [PDF]
PLoS ONE, 2012 The aim of this study was to establish the phylogenetic relationships of trypanosomes present in blood samples of Bolivian Carollia bats. Eighteen cloned stocks were isolated from 115 bats belonging to Carollia perspicillata (Phyllostomidae) from three ...
Lineth García +5 more
doaj +1 more source
Plasminogen interaction with Trypanosoma cruzi [PDF]
Memórias do Instituto Oswaldo Cruz, 2004 The ability of Trypanosoma cruzi to interact with plasminogen, the zimogenic form of the blood serin protease plasmin, was examined. Immunohistochemistry studies revealed that both forms, epimastigotes and metacyclic trypomastigotes, were able to fix plasminogen in a lysine dependant manner.
Laura Almeida +4 more
openaire +5 more sources
Protective immunity against Trypanosoma cruzi [PDF]
, 2009 Upon infection, Trypanosoma cruzi triggers a strong immune response that has both protective and pathological consequences. In this work, several important questions regarding protective immunity are reviewed.
Basombrío, Miguel Ángel Manuel +2 more
core +1 more source
Reference Module in Biomedical Sciences, 2020 During differentiation of the dividing epimastigote to the non-dividing metacyclic trypomastigote form of the parasitic protozoan Trypanosoma cruzi there is a marked reduction in the rate of synthesis of the major proteins u- and /?-tubulin.
E. Rondinelli +5 more
semanticscholar +1 more source
International meeting: New diagnostic tests are urgently needed to treat patients with Chagas disease. [PDF]
, 2008 Trypanosoma cruzi infection is often not detected early on or actively diagnosed, partly because most infected individuals are either asymptomatic or oligosymptomatic.
Campaign for Access to Essential Medicines
core +3 more sources
Ecological host fitting of Trypanosoma cruzi TcI in Bolivia: mosaic population structure, hybridization and a role for humans in Andean parasite dispersal. [PDF]
, 2015 An improved understanding of how a parasite species exploits its genetic repertoire to colonize novel hosts and environmental niches is crucial to establish the epidemiological risk associated with emergent pathogenic genotypes.
Bustamante, Marinely +8 more
core +4 more sources