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mRNA processing in the Trypanosomatidae

Experientia, 1991
Members of the Trypanosomatidae, which include the African trypanosomes, the American trypanosomes and the leishmanias, cause disease in vast proportions in man and his livestock and are a major detrimental factor to the social and economic well-being of the third world.
K, Perry, N, Agabian
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Purine and pyrimidine metabolism in the trypanosomatidae

Molecular and Biochemical Parasitology, 1984
The pathways leading to purine and pyrimidine nucleotide production in members of the family Trypanosomatidae are discussed with special emphasis on data relating to pathogenic species published from 1974 to 1983 inclusive. Trypanosomes and leishmania in general lack a de novo purine biosynthetic pathway, but have a multiplicity of possible routes for ...
D J, Hammond, W E, Gutteridge
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The molecular evolution of trypanosomatidae

2001
In the absence of a fossil record, theories relating to the evolution of protozoa have, for most of the twentieth century, been based on morphological and life cycle data despite their known limitations. However, recent advances in molecular methodology, notably the wide availability of accurate, automated DNA sequencing, have made it possible to ...
J R, Stevens   +3 more
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Genetic Exchange in the Trypanosomatidae

1999
The only trypanosomatid so far proved to undergo genetic exchange is Trypanosoma brucei, for which hybrid production after co-transmission of different parental strains through the tsetse fly vector has been demonstrated experimentally. Analogous mating experiments have been attempted with other Trypanosoma and Leishmania species, so far without ...
Gibson, WC, Stevens, JR
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Pyrazolopyrimidine metabolism in the pathogenic trypanosomatidae

Molecular and Biochemical Parasitology, 1983
Pyrazolopyrimidines are purine analogues. These compounds are metabolized by the pathogenic hemoflagellates and other members of the family Trypanosomatidae as though they were purines. This metabolic sequence does not exist in man or other mammals. In the hemoflagellates, the pyrazolopyrimidine base, of which allopurinol is the paradigm, undergoes ...
J J, Marr, R L, Berens
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Differences in Energy Metabolism Between Trypanosomatidae

Parasitology Today, 1998
Although various members of the family Trypanosomatidae generate energy in a similar way, fundamental differences also exist and are not always recognized. In this review, Louis Tielens and Jaap Van Hellemond discuss the known differences in carbohydrate metabolism among trypanosomatids, and especially compare Leishmania with trypanosomatids such as ...
Tielens, A G, Van Hellemond, J J
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Vector Relationships in the Trypanosomatidae

1977
Publisher Summary This chapter discusses the interaction between trypanosomatid flagellates and their invertebrate hosts—the majority of those discussed are vectors. It also discusses the lower vertebrate trypanosomes and their vectors and mammalian trypanosomes and their vectors. Trypanosoma (Herpetosorna) rangeli (T.
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Pellicular Microtubules in the Family Trypanosomatidae*

The Journal of Protozoology, 1970
SYNOPSIS. Flagellates of 7 species from 5 genera of the family Trypanosomatidae were prepared for electron microscopy using a combination of surface tension spreading on a simplified Langmuir trough followed by critical point drying. These technics opened the cells and showed the microtubular complex in its 3‐dimensional configuration or in a flat ...
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Experimental glimpses at the lower trypanosomatidae

Experimental Parasitology, 1963
Abstract Some aspects of researches involving primarily the genus Crithidia have been reviewed. These studies include: early nutritional studies (prior to 1950); the design of defined media; discovery, biosynthesis, and function of Crithidia Factor; carbohydrate metabolism; experimental clues to evolution; morphogenesis; and the problem of ...
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