Results 1 to 10 of about 5,880 (118)
Behind Base J: The Roles of JBP1 and JBP2 on Trypanosomatids
Pathogens, 2023 β-D-glucopyranosyloxymethiluracil (Base J) is a modified thymidine base found in kinetoplastids and some related organisms. Interestingly, Base J distribution into the genome can vary depending on the organism and its life stage. Base J is reported to be
Maria Isabel Nogueira Cano +2 more
exaly +3 more sources
Screening Marine Natural Products for New Drug Leads against Trypanosomatids and Malaria
Marine Drugs, 2020 Neglected Tropical Diseases (NTD) represent a serious threat to humans, especially for those living in poor or developing countries. Almost one-sixth of the world population is at risk of suffering from these diseases and many thousands die because of ...
Babu Tekwani +2 more
exaly +3 more sources
The Roles of Mosquitoes in the Circulation of Monoxenous Trypanosomatids in Temperate Climates
Pathogens, 2022 Monoxenous (insect-restricted) trypanosomatids are highly diverse and abundant in nature. While many papers focus on the taxonomy and distribution of these parasites, studies on their biology are still scarce. In particular, this concerns trypanosomatids
Alexei Y. Kostygov +7 more
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LeishIF3d is a non-canonical cap-binding protein in Leishmania
Frontiers in Molecular Biosciences, 2023 Translation of most cellular mRNAs in eukaryotes proceeds through a cap-dependent pathway, whereby the cap-binding complex, eIF4F, anchors the pre-initiation complex at the 5′ end of mRNAs driving translation initiation.
Priyanka Bose +4 more
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Molecular and Functional Characteristics of DNA Polymerase Beta-Like Enzymes From Trypanosomatids
Frontiers in Cellular and Infection Microbiology, 2021 Trypanosomatids are a group of primitive unicellular eukaryotes that can cause diseases in plants, insects, animals, and humans. Kinetoplast genome integrity is key to trypanosomatid cell survival and viability.
Edio Maldonado +3 more
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Is the mitochondrion a promising drug target in trypanosomatids?
Memorias do Instituto Oswaldo Cruz, 2022 The trypanosomatids Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are etiological agents of important neglected tropical diseases, affecting millions of people worldwide, and the drugs available for these diseases present several limitations.
Yasmin Pedra-Rezende +2 more
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Screening of Honey Bee Pathogens in the Czech Republic and Their Prevalence in Various Habitats
Insects, 2021 Western honey bee (Apis mellifera) is one of the most important pollinators in the world. Thus, a recent honey bee health decline and frequent honey bee mass losses have drawn attention and concern.
Petr Mráz +7 more
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Frontiers in Cellular and Infection Microbiology, 2021 Trypanosoma rangeli is the second most common American trypanosome that infects man. It is vectored by triatomines from the genus Rhodnius, in which it invades the hemolymph and infects the salivary glands, avoiding the bug immune responses.
Agustín Rolandelli +4 more
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Revista Chilena de Entomología, 2020 The present study aims to describe the occurrence of triatomines and their infection rate by Trypanosoma cruzi, in an area of Chagas disease outbreak in Rodrigues Alves municipality, Acre state, Brazil.
Fernanda Portela Madeira +9 more
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Insects, 2020 Alien insect species may present a multifaceted threat to ecosystems into which they are introduced. In addition to the direct damage they may cause, they may also bring novel diseases and parasites and/or have the capacity to vector microorganisms that ...
Courtney L. Pike +3 more
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