Results 31 to 40 of about 3,248 (167)

Inhibitors of Farnesyl Diphosphate Synthase and Squalene Synthase: Potential Source for Anti-Trypanosomatidae Drug Discovery

open access: yesDrugs and Drug Candidates, 2023
Trypanosomatids are mainly responsible for leishmaniasis, sleeping sickness, and Chagas disease, which are the most challenging among the neglected tropical diseases due to the problem of drug resistance.
Boniface Pone Kamdem   +1 more
doaj   +1 more source

Leishmania Encodes a Bacterium-like 2,4-Dienoyl-Coenzyme A Reductase That Is Required for Fatty Acid β-Oxidation and Intracellular Parasite Survival

open access: yesmBio, 2020
Leishmania spp. are protozoan parasites that cause a spectrum of important diseases in humans. These parasites develop as extracellular promastigotes in the digestive tract of their insect vectors and as obligate intracellular amastigotes that infect ...
Geo Semini   +10 more
doaj   +1 more source

From a mono to a digenetic life-cycle: how was the jump for flagellates of the family trypanosomatidae?

open access: yesMemorias do Instituto Oswaldo Cruz, 1988
It has been found that species of the digenetic genus Trypanosoma as well as species of monogenetic trypanosomatids of insects can grow in the lumen of the scent glands of opossums reproducing the cycle they perform in the intestinal tract of their ...
Maria P. Deane, Ana M. Jansen
doaj   +1 more source

Genomic Variation among Strains of Crithidia bombi and C. expoeki

open access: yesmSphere, 2019
In this study, we sequenced and analyzed the genomes of 40 strains, in addition to the already-reported two type strains, of two Crithidia species infecting bumblebees in Alaska and Central Europe and demonstrated that different strains of Crithidia ...
Evgeny Gerasimov   +4 more
doaj   +1 more source

Relato de infecção natural de morcegos por flagelados tripanosomatideos em diferentes municípios do Estado do Rio de Janeiro Report on natural infection of bats by trypanosomatid flagellates in different municipalities in the State of Rio de Janeiro

open access: yesRevista da Sociedade Brasileira de Medicina Tropical, 2008
Este trabalho objetivou avaliar a infecção natural de morcegos por tripanosomatídeos. Foram examinados, por hemocultura, 86 exemplares de diferentes gêneros, sendo 22 (25,58%) amostras isoladas de Desmodus rotundus e Lonchorhina aurita.
Juliana Helena da Silva Barros   +4 more
doaj   +1 more source

Common pathways and outliers in glucose catabolism across Trypanosomatidae

open access: yesThe FEBS Journal, EarlyView.
Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes   +5 more
wiley   +1 more source

Revised classification of the subfamily Leishmaniinae (Trypanosomatidae) [PDF]

open access: yesFolia Parasitologica, 2017
In the present study, we critically revised the recently proposed classification of the subfamily Leishmaniinae Maslov et Lukeš in Jirků et al., 2012. Agreeing with erection of the genus Zelonia Shaw, Camargo et Teixeira in Espinosa et al., 2017 and the subgenus Mundinia Shaw, Camargo et Teixeira in Espinosa et al., 2017 within the genus Leishmania ...
Alexei Y, Kostygov   +1 more
openaire   +3 more sources

Entomological surveillance of Trypanosoma cruzi vectors in Rio Grande do Norte, Brazil

open access: yesMedical and Veterinary Entomology, EarlyView.
Discontinuous entomological surveillance and persistent infestation by triatomines highlight the risk of Trypanosoma cruzi transmission. The diversity of triatomine species in the peridomicile shows the potential for colonization into the home. The wide distribution of Triatoma brasiliensis and Triatoma pseudomaculata accompanies high rates of ...
Letícia Mikardya Lima Sales   +10 more
wiley   +1 more source

TriTrypDB: a functional genomic resource for the Trypanosomatidae [PDF]

open access: yesNucleic Acids Research, 2009
TriTrypDB (http://tritrypdb.org) is an integrated database providing access to genome-scale datasets for kinetoplastid parasites, and supporting a variety of complex queries driven by research and development needs. TriTrypDB is a collaborative project, utilizing the GUS/WDK computational infrastructure developed by the Eukaryotic Pathogen ...
Martin Aslett   +43 more
openaire   +2 more sources

Peridomestic infestation by Triatoma pallidipennis and natural infection with Trypanosoma cruzi in Zacatepec, Morelos, Mexico Infestación peridoméstica por Triatoma pallidipennis e infección natural por Trypanosoma cruzi en Zacatepec, Morelos, México

open access: yesMedical and Veterinary Entomology, EarlyView.
Entomological and community‐related risk factors for Chagas disease were assessed through peridomestic sampling, calculation of entomological indices and surveys of community knowledge, attitudes and practices. Forty‐six triatomines, all identified as Triatoma pallidipennis, were collected, and all specimens showed natural infection with Trypanosoma ...
Reyna Vargas‐Abasolo   +5 more
wiley   +1 more source

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