Results 61 to 70 of about 5,037 (202)

Leishmania (Viannia) infection in a horse in the state of Goiás, Brazil [PDF]

Ciência Rural
: This research reports the clinical, histological, immunohistochemical, and molecular findings of a case of leishmaniasis by Leishmania (Viannia) in an equid in the state of Goiás, Brazil. Nodular lesions, sometimes crusty or ulcerated, were observed on
Mariana Fagundes Bento, Eduardo de Paula Nascente, Ana Paula Iglesias Santin, Rodrigo Caldas Menezes, Luiz Cláudio Ferreira, Monique Paiva Campos, Veridiana Maria Brianezi Dignani de Moura   +6 more
doaj   +2 more sources

Pyridyl‐Thiazole‐Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa, Graziella Leite Brondani, Tacylla Lima Silva, Wéllyda Belmira de Lira Silva, Natáli Tereza Capistrano Costa, Marcelo Zaldini Hernandes, Policarpo Ademar Sales Junior, Valéria Rêgo Alves Pereira, Ana Cristina Lima Leite   +10 more
wiley   +1 more source

Synthesis, Electrochemistry, In Vitro Antiprotozoal Efficacy and Mechanistic Study of Novel ‘Ferrantoin’ and Related Derivatives

Applied Organometallic Chemistry, Volume 40, Issue 7, July 2026.
1,2‐Disubstituted ferrocene analogues bearing hydantoin or rhodanine synthons were synthesised and assessed for antitrypanosomatid activity. An antileishmanial early lead, analogue 23, acting through ROS generation and hence oxidative stress, was uncovered.
Maryna Saayman, Janine Aucamp, Helena D. Janse van Rensburg, Christina Kannigadu, Rotondwa Mphephu, Andrew J. Swarts, Keisuke Suganuma, David D. N'Da   +7 more
wiley   +1 more source

A New Model Trypanosomatid, Novymonas esmeraldas: Genomic Perception of Its “Candidatus Pandoraea novymonadis” Endosymbiont

mBio, 2021
The closest relative of human pathogen Leishmania, the trypanosomatid Novymonas esmeraldas, harbors a bacterial endosymbiont “Candidatus Pandoraea novymonadis.” Based on genomic data, we performed a detailed characterization of the metabolic interactions
Alexandra Zakharova, Andreu Saura, Anzhelika Butenko, Lucie Podešvová, Sandra Warmusová, Alexei Yu. Kostygov, Anna Nenarokova, Julius Lukeš, Fred R. Opperdoes, Vyacheslav Yurchenko   +9 more
doaj   +1 more source

Sequence alignment data for trypanosomatidae parasites found in Philornis downsi from the Galapagos Islands

, 2020
Sequences of parasites in Philornis downsi, an invasive parasitic Dipteran species, were obtained via PCR tests targeting the 18S rRNA gene of the Trypanosomatidae family.
Courtney Pike (7017137), Charlotte Causton (7017143), Piedad Lincango (7017140), Patricia Parker (3326832)   +3 more
core   +1 more source

Potential vectors of Leishmaniases in the Environmental Protection Area and Tinguá Federal Biological Reserve, Municipality of Nova Iguaçu, Rio de Janeiro, Brazil

Medical and Veterinary Entomology, Volume 40, Issue 2, Page 246-259, June 2026.
This study was to describe the composition of sand fly fauna, detect potential vectors of Leishmania spp. in the Tinguá district, an ATL endemic, Rio de Janeiro, Brazil. Seven species of vectorial importance in the epidemiological cycle of leishmaniasis was observed: Nyssomyia intermedia, Migonemyia migonei, Pintomyia fischeri, Psychodopygus hirsutus ...
Antônio L. F. Santana, Alfredo C. R. Azevedo, Margarete M. S. Afonso, Bruno M. Carvalho, Vanessa R. Vieira, Simone M. Costa, Júlia S. Silva, Thais A. Pereira, Daniela P. Pereira, Maurício L. Vilela   +9 more
wiley   +1 more source

Molecular Diagnosis and Prevalence of Trypanosoma vivax (Trypanosomatida: Trypanosomatidae) in Buffaloes and Ectoparasites in the Brazilian Amazon Region

Journal of Medical Entomology, 2020
AbstractTrypanosoma vivax Ziemann is a parasite that affects both wild and domestic ungulates and is transmitted mechanically via tabanids and other blood-sucking insects in the Americas. A total of 621 blood samples from water buffaloes (Bubalus bubalis (Linnaeus) (Artiodactyla: Bovidae), and 184 ectoparasite samples (Amblyomma cajennense (Fabricius ...
Gustavo Henrique Souza Dyonisio, Helder Ribeiro Batista, Ryan Emiliano da Silva, Roberta Carvalho de Freitas e Azevedo, Jaciara de Oliveira Jorge Costa, Ingridi Braz de Oliveira Manhães, Renata Tonhosolo, Solange Maria Gennari, Antonio Humberto Hamad Minervino, Arlei Marcili   +9 more
openaire   +2 more sources

Canine Leishmaniasis in Rio de Janeiro, Brazil (2000–2015): Taxonomic Characterisation of Etiological Agents and Geospatial Case Analysis

Zoonoses and Public Health, Volume 73, Issue 4, Page 314-325, June 2026.
ABSTRACT Introduction Canine Leishmaniasis is a vector‐borne zoonotic disease caused by several species of protozoa of the genus Leishmania. In the state of Rio de Janeiro (RJ), Leishmania braziliensis is the most prevalent species causing tegumentary leishmaniasis (TL) and Leishmania infantum is the main causative agent of visceral leishmaniasis (VL).
Luciana de Freitas Campos Miranda, Laryssa Fabiano do Rosário Coelho, Samanta Cristina das Chagas Xavier, Artur Augusto Velho Mendes Junior, Renan Nunes Albuquerque, Aline Fagundes da Silva, Andreza Pain Marcelino, Fernanda Nunes Santos, Sandro Antonio Pereira, Rodrigo Caldas Menezes, Armando de Oliveira Schubach   +10 more
wiley   +1 more source

Complex I of Trypanosomatidae: does it exist?

, 2008
The presence of complex I, or NADH dehydrogenase, in Trypanosomatidae is debated. Several subunits of complex I have been identified by biochemical studies, but the overall composition of the complex has remained elusive.
Michels, Paulus, Opperdoes, Frederik
core   +1 more source

Retracing the evolutionary history of the Trypanosomatidae: the use of kinetoplast DNA in molecular systematics, species identification and diagnostics [PDF]

, 2020
University of Technology Sydney. Faculty of Science.The Trypanosomatidae (class Kinetoplastida) are a diverse and widespread group of protists characterised by their possession of a unique and highly specialised mitochondrial homologue known as the ...
Kaufer, Alexa May
core